A scientific revolution?

Bussard, A

doi:10.1038/sj.embor.7400497

Cited by 31 publications

(25 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whereas the presence of pili in Gram-negative bacteria was reported early (Brinton, 1965;Costerton et al, 1981;Jones & Isaacson, 1983;Heckels, 1989;Orndorff & Bloch, 1990;Hultgren et al, 1991), for a long time their presence in Gram-positive bacteria were considered dubious just because it was against the current 'dogma'. Proving once more such a tenet is foreign to the world of science (Ray, 1991;Johnson, 1999;Bussard, 2005), these structures are now well recognized in these bacteria (Hayashi et al, 1985;Fujita et al, 1992;Stenfors et al, 1997;Rakotoarivonina et al, 2002;Ton-That & Schneewind, 2003Desvaux et al, 2006a). However, in Gram-positive bacterial species the involvement of FPE in the formation of proper Type 4 pili has never been investigated and, except for LPXTG-pilin polymerization via sortase , no mechanism for pili formation is yet understood.…”

Section: Discussionmentioning

confidence: 99%

The protein secretion systems inListeria: inside out bacterial virulence

2006

View full text Add to dashboard Cite

Listeria monocytogenes, the etiologic agent of listeriosis, remains a serious public health concern with its frequent occurrence in food coupled with a high mortality rate. The capacity of a bacterium to secrete proteins to or beyond the bacterial cell surface is of crucial importance in the understanding of biofilm formation and bacterial pathogenesis to further develop defensive strategies. Recent findings in protein secretion in Listeria together with the availability of complete genome sequences of several pathogenic L. monocytogenes strains, as well as nonpathogenic Listeria innocua Clip11262, prompted us to summarize the listerial protein secretion systems. Protein secretion would rely essentially on the Sec (Secretion) pathway. The twin-arginine translocation pathway seems encoded in all but one sequenced Listeria. In addition, a functional flagella export apparatus, a fimbrilin-protein exporter, some holins and a WXG100 secretion system are encoded in listerial genomes. This critical review brings new insights into the physiology and virulence of Listeria species.

show abstract

Section: Discussionmentioning

confidence: 99%

The protein secretion systems inListeria: inside out bacterial virulence

2006

View full text Add to dashboard Cite

show abstract

“…In fact, the need for the replacement of this paradigm by new concepts was reinforced by the accumulation of numerous pieces of evidence “which do not fit into the widely accepted theoretical framework of how Nature functions” [36]. Probably one of the most compelling illustrations of the need to reconsider the “one-gene–one-protein–one-function” model is given by the contradiction between the number of protein-coding genes in a human cell, which is approaching (2.0–2.5) × 10 4 [37], and the total number of human proteins with different functions, which is mounting to >2 × 10 6 [38,39,40,41,42].…”

Section: Proteoformsmentioning

confidence: 99%

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept

Uversky

2016

IJMS

151

123

View full text Add to dashboard Cite

Although it is one of the most studied proteins, p53 continues to be an enigma. This protein has numerous biological functions, possesses intrinsically disordered regions crucial for its functionality, can form both homo-tetramers and isoform-based hetero-tetramers, and is able to interact with many binding partners. It contains numerous posttranslational modifications, has several isoforms generated by alternative splicing, alternative promoter usage or alternative initiation of translation, and is commonly mutated in different cancers. Therefore, p53 serves as an important illustration of the protein structure–function continuum concept, where the generation of multiple proteoforms by various mechanisms defines the ability of this protein to have a multitude of structurally and functionally different states. Considering p53 in the light of a proteoform-based structure–function continuum represents a non-canonical and conceptually new contemplation of structure, regulation, and functionality of this important protein.

show abstract

“…Now most biologists accept the existence of prions and increasing evidence indicates that this may well be a form of protein‐based information flow, which seems to be important in various biological processes ranging from the establishment of long‐term memory to the adaptation of organisms to new environments. It has been suggested that the prion anomaly may challenge the central dogma of molecular biology and evoke a scientific revolution (Bussard, 2005). Recently, Saa, Castilla & Soto (2006) detected a misfolded prion protein biochemically in the blood of Syrian Golden hamsters ( Mesocricetus auratus ) infected with scrapie during the presymptomatic phase of the disease.…”

Section: In Search Of Darwin’s Gemmulesmentioning

confidence: 99%

A new perspective on Darwin’s Pangenesis

Liu

2008

Biological Reviews

View full text Add to dashboard Cite

In 1868 Charles Darwin proposed Pangenesis, a developmental theory of heredity. He suggested that all cells in an organism are capable of shedding minute particles he called gemmules, which are able to circulate throughout the body and finally congregate in the gonads. These particles are then transmitted to the next generation and are responsible for the transmission of characteristics from parent to offspring. If any cells of the parent undergo changes as a result of environmental change, they will consequently transmit modified gemmules to their offspring. Soon after Darwin's pangenetic theory was published, Francis Galton designed a series of blood transfusion experiments on differently pigmented rabbits to test its validity. He found no evidence in support of the existence of Darwin's gemmules and the concept of Pangenesis was largely abandoned. In this article, recent reports of successful induction of heritable changes by blood transfusion are reviewed. Detection of circulating nucleic acids and prions in plant sap and animal blood is considered as fresh evidence for the existence of gemmules. It is now apparent that a considerable revision of views on Darwin's Pangenesis must occur before a new comprehensive genetic theory can be achieved.

show abstract

A scientific revolution?

Cited by 31 publications

References 23 publications

The protein secretion systems inListeria: inside out bacterial virulence

The protein secretion systems inListeria: inside out bacterial virulence

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept

A new perspective on Darwin’s Pangenesis

Contact Info

Product

Resources

About