A Scientific and Socioeconomic Review of Betel Nut Use in Taiwan with Bioethical Reflections

Tham, Joseph; Sem, Geoffrey; Sit, Eugene; Tai, Michael Cheng-tek

doi:10.1007/s41649-017-0028-6

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…Other potentially beneficial actions of BQ chewing include relaxation, improved concentration and mood enhancement. Truck drivers, for example, chew BQ to stay awake during their long hours of work [13]. More recent and conclusive evidence, however, indicates that the consumption of areca nut alone, or in the form of BQ, has negative health effects [14].…”

Section: Why It Is Important To Understand the Effects Of Individual ...mentioning

confidence: 99%

Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?

Zhang

Chua

Dang

et al. 2022

IJMS

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Betel quid (BQ) is a package of mixed constituents that is chewed by more than 600 million people worldwide, particularly in Asia. The formulation of BQ depends on a variety of factors but typically includes areca nut, betel leaf, and slaked lime and may or may not contain tobacco. BQ chewing is strongly associated with the development of potentially malignant and malignant diseases of the mouth such as oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC), respectively. We have shown recently that the constituents of BQ vary geographically and that the capacity to induce disease reflects the distinct chemical composition of the BQ. In this review, we examined the diverse chemical constituents of BQ and their putative role in oral carcinogenesis. Four major areca alkaloids—arecoline, arecaidine, guvacoline and guvacine—together with the polyphenols, were identified as being potentially involved in oral carcinogenesis. Further, we propose that fibroblast senescence, which is induced by certain BQ components, may be a key driver of tumour progression in OSMF and OSCC. Our study emphasizes that the characterization of the detrimental or protective effects of specific BQ ingredients may facilitate the development of targeted BQ formulations to prevent and/or treat potentially malignant oral disorders and oral cancer in BQ users.

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Section: Why It Is Important To Understand the Effects Of Individual ...mentioning

confidence: 99%

Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?

Zhang

Chua

Dang

et al. 2022

IJMS

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The Effectiveness of Betel Quid Cessation among Workers through the Adoption of the Five Action Areas of the Ottawa Charter

Tseng

Tsai

et al. 2021

Substance Use & Misuse

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Betel Quid Dependence Effects on Working Memory and Remote Memory in Chewers with Concurrent Use of Cigarette and Alcohol

Lee

Wang

Lee

et al. 2021

Substance Use & Misuse

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A Scientific and Socioeconomic Review of Betel Nut Use in Taiwan with Bioethical Reflections

Cited by 6 publications

References 23 publications

Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?

Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?

The Effectiveness of Betel Quid Cessation among Workers through the Adoption of the Five Action Areas of the Ottawa Charter

Betel Quid Dependence Effects on Working Memory and Remote Memory in Chewers with Concurrent Use of Cigarette and Alcohol

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