A school refusal case with biological rhythm disturbance and melatonin therapy

Tomoda, Akemi; Miike, Teruhisa; Uezono, Keiko; Kawasaki, Terukazu

doi:10.1016/0387-7604(94)90117-1

Cited by 47 publications

(28 citation statements)

References 11 publications

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“…For example, in two cases of non-24-h sleep-wake syndrome, 5 mg of oral melatonin successfully synchronized the sleep-wake cycle to a nocturnal phase, with apparent phase shifts in the endogenous rhythms of melatonin production or core body temperature (drug given at 1700 h, Arendt et al, 1988; drug given at 2000 h, Tomoda et al, 1994). In a similar case, a nocturnal dose of 20 mg also served to regularize the sleep pattern, although endogenous melatonin and cortisol rhythms were unaffected (Folkard et al, 1990).…”

Section: Exogenous Melatonin Administration and Lightmentioning

confidence: 99%

Light Treatment for Sleep Disorders: Consensus Report

et al. 1995

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Advanced and delayed sleep phase disorders, and the hypersomnia that can accompany winter depression, have been treated successfully by appropriately timed artificial bright light exposure. Under entrainment to the 24-h day-night cycle, the sleep-wake pattern may assume various phase relationships to the circadian pacemaker, as indexed, for example, by abnormally long or short intervals between the onset of melatonin production or the core body temperature minimum and wake-up time. Advanced and delayed sleep phase syndromes and non-24-h sleep-wake syndrome have been variously ascribed to abnormal intrinsic circadian periodicity, deficiency of the entrainment mechanism, or--most simply--patterns of daily light exposure insufficient for adequate phase resetting. The timing of sleep is influenced by underlying circadian phase, but psychosocial constraints also play a major role. Exposure to light early or late in the subjective night has been used therapeutically to produce corrective phase delays or advances, respectively, in both the sleep pattern and circadian rhythms. Supplemental light exposure in fall and winter can reduce the hypersomnia of winter depression, although the therapeutic effect may be less dependent on timing.

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Section: Exogenous Melatonin Administration and Lightmentioning

confidence: 99%

Light Treatment for Sleep Disorders: Consensus Report

et al. 1995

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“…Usually, these patients receive various therapies, including light treatment (7,18,19,33,46), physical exercise treatment (24), and administration of vitamin B 12 (25,27,28) and melatonin (21,29,41) to adjust the circadian rhythm. Presently, it is considered that the markers of circadian rhythm for these patients are the profiles of plasma melatonin, cortisol, and retinal temperature.…”

mentioning

confidence: 99%

Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder

Takimoto¹,

Hamada²,

Tomoda³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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“…All of these alterations may be due to a bad sleepness quality, and at least in one case, the school delay was counteracted by melatonin circadian rhythm normalisation (Tomoda et al, 1994). Recently it was showed that the sleep/ wake cycle is mainly regulated by melatonin, being this indole more important than serotonin to this function (Dollins et al, 1994).…”

Section: Resultsmentioning

confidence: 97%

Pineal response after pyridoxine test in children

Muñóz-Hoyos¹,

Amorós-Rodríguez

Molina-Carballo

et al. 1996

J. Neural Transmission

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To characterize the pineal response to pyridoxine, plasma melatonin was measured in one hundred and twenty children 3 hours after vitamin B6 administration. The children, aged between 1.5 and 8 years, were divided in four groups as follows: a) control day group, grouping 27 children sampled at 9:00 and at 12:00; b) control night group, grouping 29 children sampled at 21:00 and at 24:00; c) pyridoxine day group, grouping 30 children sampled at 9:00, then intravenously (i.v.) injected with 3 mg/kg of pyridoxine, and sampled at 12:00; and d) pyridoxine night group, grouping 34 children sampled at 21:00, i.v. injected with 3 mg/kg of pyridoxine, and sampled at 24:00. Melatonin concentration was measured by radioimmuno assay. The data obtained showed a significant increase in melatonin levels after pyridoxine administration in the pyridoxine night group (39.87 +/- 8.02 pg/ml basal vs 88.45 +/- 9.21 pg/ml after pyridoxine, p < 0.001). The other groups did not showed significant differences in melatonin concentrations. Statistical analysis shows that the administration of pyridoxine during the nocturnal hours represents a stimulating factor to increase the pineal production of melatonin in children.

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A school refusal case with biological rhythm disturbance and melatonin therapy

Cited by 47 publications

References 11 publications

Light Treatment for Sleep Disorders: Consensus Report

Light Treatment for Sleep Disorders: Consensus Report

Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder

Pineal response after pyridoxine test in children

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