BACKGROUND
Endovascular stenting is an effective treatment for patients with clinically significant cerebral venous sinus stenosis. Traditionally, stenting is indicated in patients with elevated intravenous pressures on conventional venography; however, noninvasive monitoring is more desirable. Quantitative magnetic resonance angiography is an imaging modality that allows blood flow assessment noninvasively. Established in the arterial system, applications to the venous sinuses have been limited to date.
OBJECTIVE
In this study, we examined quantitative magnetic resonance venography (qMRV) flow in patients before and after venous stenting and correlated these results with intravenous pressure measurements and clinical outcomes.
METHODS
Five patients with intracranial hypertension (IH) secondary to venous sinus stenosis underwent cerebral venous stenting between 2009 and 2013 at a single institution. Preoperatively venous sinus flow was determined using qMRV, and intravenous pressure measured during venography. After stenting, intravenous pressure, qMRV flow, and clinical outcomes were assessed and compared.
RESULTS
A mean prestenotic intravenous pressure of 45.2 mmHg was recorded before stenting which decreased to 27.4mmHg afterwards (Wilcoxon signed rank test P=.04). Total jugular outflow on qMRV increased by 260.2 ml/min. Analysis of the change in intravenous pressure and qMRV flow identified a linear relationship (Pearson's correlation r= .926). All patients displayed clinical improvement, including vision.
CONCLUSION
Venous outflow by qMRV increases after endovascular stenting and correlates with significantly improved intravenous pressures. These findings establish qMRV as a useful adjunct to measure venous flow after stenting, and as a potential tool in the selection and postoperative surveillance of the cerebral venous sinus stenosis patient.