A Scenario of Cervical Carcinoma in a Cancer Hospital

Jha, Anjani Kumar; Jha, Jyoti; Bista, Rabin; Basnet, Bhupendra Kumar; Kandel, Prakash; Lama, Gina; Banthia, Prasan; Thakali, Kabir

doi:10.31729/jnma.180

Cited by 11 publications

(9 citation statements)

References 8 publications

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“…16 In a study by Jha et al 29% cases were of cervical carcinoma and about 71% of them were of age group 40-59 years. 17 These findings were similar to our study. In our study, cervical cancer was detected in age group of 40-59 years and was significantly high (p value <0.005) followed by age group above 60 years.…”

Section: Discussionsupporting

confidence: 92%

Study of Cervical Biopsy over a Decade at a Tertiary Level Hospital, Nepal

Tamrakar

Shrestha

2019

Nep. Med. Coll. J.

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Cervical carcinoma is the most common gynecological malignancy and almost curable cancer, if identified at an early stage. Cervical biopsy remains the ‘gold standard’ for the diagnosis of precancerous cervical lesion. The objective of this study was to review the histopathological findings of cervical biopsy including cervical polypectomy and hysterectomy specimens at Dhulikhel Hospital from January 2008 to December 2018. Out of 2098 cases, almost half of the cases (49.3%) were of Brahmin/Chhetri castes. There were significant differences in mean ages among hysterectomy cases (47.55±9.26), cervical biopsy cases (43.08±11.50) and polypectomy cases (33.59±12.47) (p value < 0.005). Out of 925 cervical specimens (cervical biopsy and polypectomy), colposcopy and hysteroscopy were performed in 18.2% and 12.7%, respectively. Out of 1173 hysterectomies, there were 110 cases (9.4%) of malignancies and cervical cancer was the most common (67, 60.9%). The mean age of cervical cancer patients was 52.87±11.94 years. Cervical cancer detected in age group of 40 – 59 years was significantly high (p value < 0.005). Incidence of cervical cancer was lowest in Brahmin/Chhetris (2.4%) compared to Newars (3.4%) and other Janajatis (12.8%) and the difference was statistically significant (p value < 0.005). The findings of this study is useful in updating the histopathological pattern of cervical biopsies.

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Section: Discussionsupporting

confidence: 92%

Study of Cervical Biopsy over a Decade at a Tertiary Level Hospital, Nepal

Tamrakar

Shrestha

2019

Nep. Med. Coll. J.

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“…Herbart A et al [12] studied that 90% of patients of CIN III are diagnosed under 50 years, who done a 3-year study of the population of Southampton and south-west Hampshire, there were 10 times as many cases of CIN III compared with invasive squamous carcinoma (700 compared with 70). In the present study, most of the patients of CIN III were from the age group of 30-50 years which is in accordance with, Nortam Sharma et al, [13] analysed 3370 cases of invasive carcinoma cervix. Majority of the patients were in the age group of 40-50 years.…”

Section: Discussionsupporting

confidence: 90%

Comparative study of expression of keratins 8, 10, 13 and 17 in CIN III and invasive carcinoma of cervix

Bundela

Vahikar

et al. 2019

Trop J Pathol Microbiol

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Introduction: The role of keratin expression patterns as candidate tumour markers continues to be under investigation in human cervix carcinogenesis. Keratin comprise of family of at least 20 intermediate filament proteins that have a specific distribution pattern in epithelial tissue. Objective: The present study was conducted with an aim to identify CINI, II and CINIII in tissue sections with the help of immunohistochemistry of specific diagnostic markers so as to reduce the burden of invasive cervical carcinoma and to evaluate the role of cytokeratin 8,10,13 and 17 for differentiating CINIII from cervical carcinoma along with its correlation with histopathological diagnosis of these lesions. Method: We examined the immunohistochemical staining of CK8, CK10, CK13 and CK17 in 64 cases of reference cervix, CINIII lesions and invasive cervical carcinoma. Results: In present study cytokeratin 8 has sensitivity 40% and specificity 100%, cytokeratin 10 has sensitivity 80% and specificity 40%, cytokeratin 13 has sensitivity 100% and specificity 80% and cytokeratin 17 has sensitivity 40% and specificity 100% in invasive cervical carcinoma. In the CIN III lesions, cytokeratin 8 has sensitivity 56% and specificity 100%, cytokeratin 10 has sensitivity 80% and specificity 79%, cytokeratin 13 has sensitivity 100% and specificity 75% and cytokeratin 17 has sensitivity 72% and specificity 100% in cervical intraepithelial lesion III. Conclusions: We observed that expression of keratins 8 and 17 and loss of keratins 10 and 13 are good markers of malignant transformation in human cervix. Keratin expression patterns, namely expressions of keratin 10 can be useful for studying and grading squamous cell carcinomas of the cervix.

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“…The median age of women in our study was 56.22 years, ranging from 31-90 years. The maximum number of cases (CIN III and SCC) were in the age group of 40-60 years which is consistent with data from other studies [16,17].…”

Section: Tropical Journal Of Pathology and Microbiologysupporting

confidence: 92%

The use of molecular markers (Ki67 & p53) in premalignant and malignant cervical neoplasms

Mishra

Vahikar

Mitra

et al. 2016

Trop J Pathol Microbiol

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Introduction: Cervical cancers are the second most frequent type of cancer in females. It develops from premalignant to invasive stages in a multistep process of carcinogenesis. The differentiation between cervical intraepithelial neoplasia III (CIN III) and early squamous cell carcinoma (SCC) of the cervix could be difficult to diagnose in certain situations unless we see the invasion. The objective of the study was to determine the expression of p53 & Ki67 in CIN and cervical cancers and its correlation with grading and differentiation of cervical cancers with special emphasis on whether the use of Ki67 & p53 markers could help in differentiating CIN III from early SCC. Material and Methods: A prospective study on 90 cases of cervical biopsies, including-cases of : chronic cervicitis (40), CIN III (19) and invasive carcinoma (31). All cases were evaluated by immunohistochemistry using Ki67 & p53 monoclonal antibodies. Results: Both Ki67 & p53 showed higher expression in CIN III and invasive cervical carcinoma than chronic cervicitis with statistically significant difference p<0.01 and p<0.001 respectively. High significant difference of p53 & Ki67 expression was found between patients with CIN III and invasive cervical carcinomas. There was a clear trend for increasing number of cases with positive Ki67 & p53 index with increasing grades of cervical cancer. Conclusion: Ki67 & p53 showed increased expression from CIN III to SCC and it may be helpful adjunct in differentiating these two lesions. These markers could be used as biomarkers in the evaluation of the proliferative activity and progressive potential of dysplastic and neoplastic changes.

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A Scenario of Cervical Carcinoma in a Cancer Hospital

Cited by 11 publications

References 8 publications

Study of Cervical Biopsy over a Decade at a Tertiary Level Hospital, Nepal

Study of Cervical Biopsy over a Decade at a Tertiary Level Hospital, Nepal

Comparative study of expression of keratins 8, 10, 13 and 17 in CIN III and invasive carcinoma of cervix

The use of molecular markers (Ki67 & p53) in premalignant and malignant cervical neoplasms

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