2013
DOI: 10.1371/journal.pbio.1001724
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A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer

Abstract: Ben Scheres and colleagues report that in the growing tip of plant roots, a gene regulatory network that includes the plant homologue of Retinoblastoma regulates the divisions of long-term stem cells to replenish tissue and to protect the root stem cell niche.

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Cited by 145 publications
(200 citation statements)
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“…Additionally, RAM identity and patterning are tightly linked to cell division regulation. For instance, RETINOBLASTOMA-RELATED interacts with SCR to regulate quiescence in the QC by repressing an asymmetric cell division that generates short-term stem cells (Cruz-Ramírez et al, 2013). The cell cycle switch gene CCS52A (an activator of the anaphase promoting complex/cyclosome [APC/C]) regulates the identity of the QC by repressing mitotic activity in these cells (Vanstraelen et al, 2009).…”
Section: Discussion Rangap Mutant Developmental Phenotypes Are Indepementioning
confidence: 99%
“…Additionally, RAM identity and patterning are tightly linked to cell division regulation. For instance, RETINOBLASTOMA-RELATED interacts with SCR to regulate quiescence in the QC by repressing an asymmetric cell division that generates short-term stem cells (Cruz-Ramírez et al, 2013). The cell cycle switch gene CCS52A (an activator of the anaphase promoting complex/cyclosome [APC/C]) regulates the identity of the QC by repressing mitotic activity in these cells (Vanstraelen et al, 2009).…”
Section: Discussion Rangap Mutant Developmental Phenotypes Are Indepementioning
confidence: 99%
“…A decrease in GRF levels blurred this sharp transition: periclinal cell divisions, which are typical of stem cells, were observed among TACs, whereas markers of the QC and the stem cells extended their expression into the meristem. Cells in the SCN also proliferate at a much slower frequency than the surrounding transit-amplifying meristematic cells (Dolan et al, 1993;Kerk et al, 2000;Campilho et al, 2006;Cruz-Ramírez et al, 2013;Heyman et al, 2013), and a modification of the GRF levels in TACs modified the cell cycle length accordingly.…”
Section: Grfs Repress Stem Cell-like Properties In Tacsmentioning
confidence: 99%
“…To investigate a possible role of RBR in the regulation of cell differentiation in the TZ, we used transgenic lines with reduced levels of RBR due to the expression of an artificial microRNA for gene-silencing overcome (amiGO) targeting the RBR sequence under the 35S promoter (35S pro :amiGORBR) (Cruz-Ramírez et al, 2013). 35S pro :amiGORBR roots displayed an enlarged meristem with an increased number of meristematic cells that resulted in longer roots ( Figures 1B, 1E, and 1F; see Supplemental Figure 1B online), suggesting that RBR acts as a negative regulator of root meristem size and root growth.…”
Section: Rbr Influences Root Meristem Sizementioning
confidence: 99%