A scanning electron microscopy study of the effect of proteinase inhibitors on mouse uterine morphology

Noonan, Sharon M.; Dabich, Danica; Andary, Thomas J.; Pitchford, W. C.

doi:10.1530/jrf.0.0590519

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1981

1985

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“…Earlier studies have effectively revealed that in trauterine injections of proteinase inhibitors impair fer tility in the mouse [Dabich and Andary, 1974] and mod ify the morphology of the reproductive tract itself [Noonan et al, 1980], In the rabbit, when specific pro teinase inhibitors are administered in vivo intrauterally, the dissolution of the blastocyst coverings is blocked and implantation is inhibited [Denker, 1977[Denker, , 1978[Denker, . 1980.…”

Section: Introductionmentioning

confidence: 99%

Effect of Proteinase Inhibitors on Rabbit Uterine Ultrastructure

Lescoat¹

1985

Cells Tissues Organs

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Rabbit uterine epithelium was examined by electron microscopy after treatment with two proteinase inhibitors, aprotinin and antipain, administered as a single injection. Both compounds had similar effects, those of antipain being slighter. After treatment, uterine epithelium showed an increased number of very enlarged cells. Lateral cell membranes were often brocken off; basal cell membrane and basement membrane integrities are impaired. The possible interference of the system proteinase-proteinase inhibitors with the implantation process was discussed.

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Section: Introductionmentioning

confidence: 99%