A scanning electron microscopic study of nasal respiratory epithelium in pregnant rats

Güven, Gül

doi:10.1016/j.aanat.2006.04.002

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Thickening of the basement membrane was due to the accumulation of fibronectin and types I, III and V collagens [ 30 ]. The later changes were consistent with Güven and Ortuǧ [ 15 ], who reported a change in intracellular actin cytoskeleton dynamics in response to fluctuation in estrogen hormone levels.…”

Section: Discussionsupporting

confidence: 90%

“…Considering this result, we have used eight rats per group in this study. Also, a similar sample size was used in a former study [ 15 ]. This study was approved by the Ethical Committee of Faculty of Dentistry, Tanta university and were conducted in accordance with the guidelines laid down by the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines for conducting animal research.…”

Section: Methodsmentioning

confidence: 99%

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Immunohistochemical expression of estrogen receptor alpha in the maxillary sinus, pulp, and periodontal ligament of adjacent teeth in late pregnancy in rats

2022

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This study aimed to assess the histological changes in the maxillary sinus and its adjacent dental tissues as pulp and periodontal ligament during pregnancy and investigate the role of estrogen hormone in these changes through the detection of estrogen receptors in these tissues. Sixteen adult female rats were used and were allocated into two groups: control non-pregnant (n = 8) and pregnant (n = 8). They were sacrificed and their heads were prepared for histological and immunohistochemical examination for estrogen receptor alpha. Our results revealed that pregnant rats revealed inflammatory changes in the sinus as thick epithelial lining, loss of cilia, swollen goblet cells, intraepithelial and interstitial edema. The lamina propria demonstrated considerable infiltration of inflammatory cells, glandular hyperplasia with vacuolar degeneration, and vascular congestion. Periodontal ligament and pulp revealed hyperemia and vascular congestion. Immunohistochemical examination of estrogen receptor alpha in the maxillary sinus and adjacent dental tissues (Periodontal ligament and pulp) in pregnant rats revealed a significant increase in its expression in all examined tissues. In conclusion, there was an increase in expression of ERα in the sinus mucosa and dental tissues during pregnancy together with slight inflammatory changes in these tissues. Hence, dentists should be aware of the effect of these changes on the pregnant women avoiding teeth extraction due to misdiagnosis of dental, periodontal or sinus pain after exclusion of true pathologies.

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Immunohistochemical expression of estrogen receptor alpha in the maxillary sinus, pulp, and periodontal ligament of adjacent teeth in late pregnancy in rats

2022

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show abstract

“…Therefore, few efforts have been done to identify physiological bases for such changes at the olfactory bulb and mucosa levels. Some works mention that hormonal changes linked to pregnancy affect nasal airflow (Demir et al, 2015), olfactory structure and vascularisation (Guven and Ortug, 2006), that estrogen could mediate enhanced proliferation of neurons as shown in vomeronasal organ (Oboti et al, 2015) but that progesterone reduces sensitivity to odorants in the OM (Kanageswaran et al, 2016).…”

Section: Influence Of Pregnancymentioning

confidence: 99%