“…However, bottom-up DNA self-assembly tends to suffer from high defect rates [2]; therefore, breakthroughs are needed for defect modeling, defect diagnosis, and yield improvement at the nanoscale. Despite considerable research on fabrication methods [3][4][5][6], computing architectures [7], and error tolerance [8][9][10][11][12], little is known about the nature and types of defects in DNA selfassembly and their relative occurrences. Moreover, prior research on this topic has not addressed the impact of these defects on emerging nanoscale devices, logic gates, and circuit functionality.…”