A Scalable, Combined-Batch, and Continuous-Flow Synthesis of a Bio-Inspired UV-B Absorber

Abstract

A new, chromatography-free synthesis for the preparation of an experimental UV-B absorber is reported. A key step of the process is a one-pot partial reduction of a symmetrical imide with a sequential dehydration step. The synthesis uses several continuous-flow steps to increase sample throughput and was used to prepare sufficient material to support further testing activities in .99 % purity.

Heron8 – The 8th Heron Conference on Reactive Intermediates and Unusual Molecules

“…The preparation relies heavily on the use of continuous-flow steps to increase sample throughput, and in this way quantities of ,0.5 kg in .99 % purity could be obtained. [2] Anthony J. Arduengo III (University of Alabama, USA) and co-workers in the USA and Japan describe the crystal structure of Burgess inner salts and their hydrolysed ammonium sulfaminates. The Burgess reagent, Et 3 N (þ) SO 2 -N (-) -COOR, has been widely used, for example, to dehydrate secondary and tertiary alcohols, amides, and nitroalkanes, and to form amines (via carbamates) from primary alcohols.…”