A saponin from astragalus promotes pancreatic ductal organoids differentiation into insulin-producing cells

Yu, Wen; Wang, Yannan; Jiang, Di; Shang, Junliang; Liu, Miao; Efferth, Thomas; Teng, Chun‐Bo

doi:10.1016/j.phymed.2022.154190

Cited by 6 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saponins lower blood glucose levels by stimulating insulin secretion from pancreatic beta cells and increasing peripheral glucose utilization. Saponins can trigger the regeneration of pancreatic beta cells and inhibition of hepatic gluconeogenesis (Yu et al, 2022). El Barky et al (2017) also reported saponin decreases serum blood glucose levels in diabetic patients.…”

Section: Resultsmentioning

confidence: 99%

Cajanus cajan Leaves and Ginger Increase Antioxidant Defence in Pancreatic Diabetic Rats: An Immunohistochemical Study

Wresdiyati,

Cahyani,

Hamzah

et al. 2024

jveteriner

View full text Add to dashboard Cite

Hyperglycemia in diabetes mellitus results in stress oxidative condition. This study aims to analyze the antioxidant defence in pancreatic experimental-diabetic rats treated with a combined extract of Cajanus cajan leaves and ginger, using an immunohistochemical technique for copper, zinc – superoxide dismutase (Cu,Zn-SOD). A total of 25 male Sprague Dawley rats were used in this study. The rats were randomly divided into five groups; normal control group (NC), diabetic group (DM), two groups DM treated with a different dose combination of Cajanus cajan leaf extract and ginger extract (DME and DMF), and DM treated with glibenclamide (DMG). This study used 110 mg/kg BW alloxan induction to obtain diabetic conditions, and the treatments of the extract were conducted for 28 days. The pancreatic tissues were processed using the paraffin standard method and an immunohistochemical technique using monoclonal antibody Cu,Zn-SOD. The results showed that a combination of Cajanus cajan leaf extract and ginger extract lowered the level of blood glucose, increased body weight, and increased the level of Cu,Zn-SOD content in pancreatic tissues of experimental-diabetic rats. This study concluded that combining Cajanus cajan leaf extract and ginger extract increased antioxidant defence in pancreatic organs of experimental-diabetic rats.

show abstract

Section: Resultsmentioning

confidence: 99%

Cajanus cajan Leaves and Ginger Increase Antioxidant Defence in Pancreatic Diabetic Rats: An Immunohistochemical Study

Wresdiyati,

Cahyani,

Hamzah

et al. 2024

jveteriner

View full text Add to dashboard Cite

show abstract

“…It is one of the most important medicinal plants used in traditional Chinese medicine. Triterpene saponins such as astragalosides I-X and isoastragalosides I-IV found in the root demonstrate anti-inflammatory, immunomodulatory, anti-diabetic, cardioprotective, hepatoprotective, anti-aging as well as anti-oxidative activity [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Determining Antiradical Capacity of Medicinal Plant Extract Individual Constituents Using Post-Column Reaction Method

Przybył,

Stefaniak,

Jaroszewicz

et al. 2024

IJMS

View full text Add to dashboard Cite

The post-column reaction method enables the evaluation of the antiradical capacity of individual components in a mixture by separating the components using HPLC and measuring stable free radical (e.g., DPPH●) scavenging that occurs after the chromatography column. The equipment typically consists of two detectors. The first records signals of the analytes leaving the column. The second records radical scavenging by the analytes, which appears as a negative band. The recorded signals are found on two separate chromatograms, which must be combined to interpret the results. In this study, a single DAD detector was used behind the post-column reactor, enabling the simultaneous recording of the analyte bands and negative signals, indicating radical scavenging. The objective of this study was to evaluate the antiradical capacity of key compounds found in two herbal raw materials used in traditional Chinese medicine. Saposhnikovia divaricata roots contain phenolic acids, chromones, and furanocoumarins. Chlorogenic acid, rosmarinic acid, and imperatorin demonstrated strong radical scavenging, while prim-O-glucoslocimifugin showed a weaker response, both in standards and in root extracts. However, scavenging was not observed for cimifugin and 4′-O-β-D-glucosyl-5-O-methylvisamminol. Astragalus mongholicus roots contain astragalosides I-IV (triterpene saponins). None of these showed DPPH● scavenging. Furthermore, additional signals were observed, indicating the presence of unidentified radical scavenging compounds.

show abstract

“…Quinoa saponins is a byproduct of quinoa processing, which can also produce foam in an aqueous solution, and this foam is stable even at very low concentration (0.1%, taste tolerable). Therefore, quinoa saponins have potential application as a foaming agent (8)(9)(10)(11)(12)(13)(14). Takeshi et al developed alcohol-free beer with saponins, indicating that the addition of saponins made beer drinks foam richer and more delicate (15).…”

Section: Introductionmentioning

confidence: 99%

Complexation of phycocyanin with hydroxypropyl-β-cyclodextrin and its application in blue beer containing quinoa saponins as foaming agents

et al. 2023

View full text Add to dashboard Cite

IntroductionWith the increasing importance attached to human health, the inclusion complex (IC) of phycocyanin (PC) into hydroxypropyl-β-cyclodextrin (HP-β-CD) have been devoted to developing the use of food preservation in this study.MethodsIn this experiment, the IC of PC into HP-β-CD was prepared by the freeze-drying method and characterized by OM, TEM, UV, FTIR and TG/DSC methods.Results and discussionThe spectroscopic features were evaluated by Ultraviolet-visible (UV-vis) spectroscopy and Fourier transform infrared spectroscopy (FT-IR) confirming that PC was located in the hydrophobic cavity of HP-β-CD. Consistent with the structural properties, optical microscopy (OM) and Transmission electron microscope (TEM) observed that the addition of PC subjected the IC to an aggregation state with irregular lamellar structures. Stability assessment showed that pH, heat and light tolerance of PC significantly regulated and improved due to the PC/HP-β-CD complexation. The formation of ICs was helpful to enhancing the antioxidant activity of PC. Molecular modeling suggested that the D-pyrrole ring and its associated C=C group of phycocyanin entered the HP-β-CD cavity from the wider edge. On this basis, the development of blue beer with quinoa saponins as foaming agent and ICs as colorant was explored. The addition of quinoa saponins made the foam richer and more delicate without destroying the overall taste coordination of beer. Moreover, the protective effect of HP-β-CD presents a positive impact on the stability of blue beer pigment. Hence, PC encapsulated into HP-β-CD will be an impressive approach in food-related application of PC.

show abstract

A saponin from astragalus promotes pancreatic ductal organoids differentiation into insulin-producing cells

Cited by 6 publications

References 16 publications

Cajanus cajan Leaves and Ginger Increase Antioxidant Defence in Pancreatic Diabetic Rats: An Immunohistochemical Study

Cajanus cajan Leaves and Ginger Increase Antioxidant Defence in Pancreatic Diabetic Rats: An Immunohistochemical Study

Determining Antiradical Capacity of Medicinal Plant Extract Individual Constituents Using Post-Column Reaction Method

Complexation of phycocyanin with hydroxypropyl-β-cyclodextrin and its application in blue beer containing quinoa saponins as foaming agents

Contact Info

Product

Resources

About