A Sandwiched Biological Fluorescent Probe for the Diagnosis of Human Ovarian Tumor Based on TiO2 Nanoparticles

Abstract

In this paper, we report a novel biological fluorescent probe for the diagnosis of human ovarian tumor based on sandwiched TiO(2) nanoparticles. The fluorescence nanoparticles consist of a fluorescent molecule, tetramethyl rhodamine isothiocyanate (TRITC), sandwiched between titanium dioxide (TiO(2)) nanoparticles and nano-gold via reacting with each other. The antibodies HER2, labeled on the surface of the biofluorescence nanoparticles, have granted nanoparticles the privilege of aiming at peculiar tumor antigen. The specificity of antibody-nanoparticles interacting with cells was characterized by Laser Scanning Confocal Microscope. The results showed that these sandwiched nanoparticles were innocuous and stable, and the method offered potential advantages of sensitivity and simplicity due to high combing efficiency between nanoparticles and cells and provided an alternative method for the diagnosis of human ovarian tumor (HOT).

Immunomodulatory Potential of Differently-Terminated Ultra-Small Silicon Carbide Nanoparticles

“…The knowledge of nanoparticles (NPs) and their potential application in the field of biomedicine as drug delivery [1,2], therapeutic [3][4][5], and diagnostic platforms and imaging devices [6] have improved significantly over recent years. While particles of different materials and sizes have been studied in detail, only a limited numbers of studies on ultra-small NPs, with sizes of less than 5 nm, have been reported [7][8][9].…”

Poly(3-Octylthiophene) and Poly(3-Octylthiophene)/TiO2-Coated on Al1050: Electrosynthesis, Characterization and Its Corrosion Protection Ability in NaCl Solution

“…Titanium dioxide (TiO 2 ) [26] has been studied extensively in recent years due to its many potential applications [27,28] , in destroying contaminants from air and water [29][30][31] , antimicrobial nanomaterials [32][33][34][35] , in photo-electrical cells [36][37][38] , water splitting [39][40][41][42] , gas sensors [43] , and cancer therapy applications [44][45][46][47] .…”