A sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes

Dorsal and Ventral Stimuli in Cell–Material Interactions: Effect on Cell Morphology

“…1) in environments closer to the in vivo 3D one. This strategy could be useful to engineer biomimetic tissues, directing physiological cell phenotypes and functionality [19]. Moreover, the double layer configuration might shed some light in fundamental cell biology studies, such as the existence of focal adhesions in 3D [20][21][22].…”

Controlled release of transforming growth factor-β3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells

“…heart valves, blood vessels, skin and cartilage [8,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]) scaffolds. In the case of articular cartilage, numerous studies have demonstrated that scaffolds derived from devitalized cartilage are chondroinductive and show great promise for regenerating damaged joints [8,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Bioactive Scaffolds for the Controlled Formation of Complex Skeletal Tissues

“…Some articles have supported the concept of decellularized cartilage as a chondroconductive matrix in cartilage tissue engineering (Elder et al, 2010;Gong et al, 2011;Hou et al, 2011;Secretan et al, 2010;Stabile et al, 2010). Indeed, in vitro tests have shown the possibility to form cartilage tissue in vitro by chondrocyte seeding on a decellularized tissue scaffold (Gong et al, 2011). This ability to support cartilage formation translates to advanced in vivo models such as a for larynx reconstruction in a rabbit model (Hou et al, 2011), or for meniscus reconstruction in sheep (Stabile et al, 2010).…”

“…That is except for DBM, which can be considered also a decellularized tissue scaffold. Some articles have supported the concept of decellularized cartilage as a chondroconductive matrix in cartilage tissue engineering (Elder et al, 2010;Gong et al, 2011;Hou et al, 2011;Secretan et al, 2010;Stabile et al, 2010). Indeed, in vitro tests have shown the possibility to form cartilage tissue in vitro by chondrocyte seeding on a decellularized tissue scaffold (Gong et al, 2011).…”