A sample volume independent paper microfluidic device for quantifying glucose in real human plasma

Choobbari, Mehrdad Lotfi; Rad, Mohammad Behnam; Jahanshahi, Amir; Ghourchian, Hedayatollah

doi:10.1007/s10404-020-02382-y

Cited by 19 publications

(8 citation statements)

References 44 publications

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“…The general paper-based microfluidic devices are easily affected by the sample volume. Choobbari et al, designed a paper-based microfluidic device that only related to the glucose concentration in the sample without accurately controlling the sample volume and the corresponding detection results could be obtained by analyzing the images captured by a smartphone [186]. Although blood is the most commonly used biological fluid for clinical diagnosis, some patients feel pain, fear, or discomfort when blood is drawn [187].…”

Section: Application Of Chronic Disease Detectionmentioning

confidence: 99%

Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges

Yang

Zhang

et al. 2022

Sensors

110

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The early diagnosis of infectious diseases is critical because it can greatly increase recovery rates and prevent the spread of diseases such as COVID-19; however, in many areas with insufficient medical facilities, the timely detection of diseases is challenging. Conventional medical testing methods require specialized laboratory equipment and well-trained operators, limiting the applicability of these tests. Microfluidic point-of-care (POC) equipment can rapidly detect diseases at low cost. This technology could be used to detect diseases in underdeveloped areas to reduce the effects of disease and improve quality of life in these areas. This review details microfluidic POC equipment and its applications. First, the concept of microfluidic POC devices is discussed. We then describe applications of microfluidic POC devices for infectious diseases, cardiovascular diseases, tumors (cancer), and chronic diseases, and discuss the future incorporation of microfluidic POC devices into applications such as wearable devices and telemedicine. Finally, the review concludes by analyzing the present state of the microfluidic field, and suggestions are made. This review is intended to call attention to the status of disease treatment in underdeveloped areas and to encourage the researchers of microfluidics to develop standards for these devices.

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Section: Application Of Chronic Disease Detectionmentioning

confidence: 99%

Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges

Yang

Zhang

et al. 2022

Sensors

110

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“…The GOD/ HRP system coupled to potassium iodide (KI) or TMB was employed for blood glucose detection, the POC platform was generated with the wax printing method using Whatman No. 1 paper as a support [ 82 ]. In order to diminish the effect of ambient light on color detection, a stand with controlled illumination was designed on which to place the smartphone [ 82 ].…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…1 paper as a support [ 82 ]. In order to diminish the effect of ambient light on color detection, a stand with controlled illumination was designed on which to place the smartphone [ 82 ]. One of the main factors affecting microfluidic platforms is the sample volume variation, which is a challenge that needs to be overcome to achieve the commercial application of a POC platform, since it would require users to introduce a standard amount of sample.…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…In this paper, a comparison was made between a volume-independent platform (VI-µPAD) and a conventional platform (C-µPAD). In the conventional platform, it is observed that the color intensity increases with higher sample volume, even though the glucose concentration remains constant [ 82 ]. In the proposed VI-µPAD platform, the sample comes in direct contact with the enzymes and chromogen, and it is the colored product that travels to the detection zone, allowing a homogeneous and uniform color intensity.…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…Moreover, this color is more related to the glucose concentration than to the sample volume. In addition, the use of TMB instead of KI for detection allows the detection limit to be significantly lower, without sacrificing its broad linear range (0–22 mM), which would allow its use for real samples with clinically relevant values [ 82 ]. In 2020, a similar wax-printed, chitosan-treated paper system sealed with lamination film to configure the µPAD was reported [ 70 ].…”

Section: Paper-based Point-of-care Platforms For Screening and Monitoring Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

See 2 more Smart Citations

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

2021

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A point-of-care (POC) can be defined as an in vitro diagnostic test that can provide results within minutes. It has gained enormous attention as a promising tool for biomarkers detection and diagnosis, as well as for screening of chronic noncommunicable diseases such as diabetes mellitus. Diabetes mellitus type 2 is one of the metabolic disorders that has grown exponentially in recent years, becoming one of the greatest challenges to health systems. Early detection and accurate diagnosis of this disorder are essential to provide adequate treatments. However, efforts to reduce incidence should remain not only in these stages but in developing continuous monitoring strategies. Diabetes-monitoring tools must be accessible and affordable; thus, POC platforms are attractive, especially paper-based ones. Paper-based POCs are simple and portable, can use different matrixes, do not require highly trained staff, and are less expensive than other platforms. These advantages enhance the viability of its application in low-income countries and hard-to-reach zones. This review aims to present a critical summary of the main components required to create a sensitive and affordable enzymatic paper-based POC, as well as an oriented analysis to highlight the main limitations and challenges of current POC devices for diabetes type 2 monitoring and future research opportunities in the field.

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Self-Powered Microfluidics for Point-of-Care Solutions: From Sampling to Detection of Proteins and Nucleic Acids

Vloemans,

Van Hileghem,

Ordutowski

et al. 2024

Methods in Molecular Biology

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A sample volume independent paper microfluidic device for quantifying glucose in real human plasma

Cited by 19 publications

References 44 publications

Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges

Microfluidic Point-of-Care (POC) Devices in Early Diagnosis: A Review of Opportunities and Challenges

Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2

Self-Powered Microfluidics for Point-of-Care Solutions: From Sampling to Detection of Proteins and Nucleic Acids

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