A Salutary Role of Reactive Oxygen Species in Intercellular Tunnel-Mediated Communication

Liang, Dacheng

doi:10.3389/fcell.2018.00002

Cited by 24 publications

(37 citation statements)

References 356 publications

(400 reference statements)

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“…In another study, transgenic tobacco carrying the 9- cis -epoxy carotenoid dioxygenase gene showed enhanced tolerance to abiotic stresses. This enhanced resistance has been linked to production of H 2 O 2 that induces the expression of ROS-scavenging enzymes [ 276 ].…”

Section: Genes Regulating Ros Homeostasis In Abiotic Stressmentioning

confidence: 99%

ROS Homeostasis in Abiotic Stress Tolerance in Plants

Nadarajah

2020

IJMS

315

146

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Climate change-induced abiotic stress results in crop yield and production losses. These stresses result in changes at the physiological and molecular level that affect the development and growth of the plant. Reactive oxygen species (ROS) is formed at high levels due to abiotic stress within different organelles, leading to cellular damage. Plants have evolved mechanisms to control the production and scavenging of ROS through enzymatic and non-enzymatic antioxidative processes. However, ROS has a dual function in abiotic stresses where, at high levels, they are toxic to cells while the same molecule can function as a signal transducer that activates a local and systemic plant defense response against stress. The effects, perception, signaling, and activation of ROS and their antioxidative responses are elaborated in this review. This review aims to provide a purview of processes involved in ROS homeostasis in plants and to identify genes that are triggered in response to abiotic-induced oxidative stress. This review articulates the importance of these genes and pathways in understanding the mechanism of resistance in plants and the importance of this information in breeding and genetically developing crops for resistance against abiotic stress in plants.

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Section: Genes Regulating Ros Homeostasis In Abiotic Stressmentioning

confidence: 99%

ROS Homeostasis in Abiotic Stress Tolerance in Plants

Nadarajah

2020

IJMS

315

146

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“…ROS play an important role in plant growth and development, especially in stress tolerance [38]. In plants, ROS regulate many developmental processes such as cell proliferation and differentiation, seed germination, programmed cell death, senescence [39][40][41][42][43]. ROS include H 2 O 2 , O 2− , singlet oxygen, and the hydroxyl radical [13,44].…”

Section: Ros Homeostasis In Leaf Abscission In Respond To Tdzmentioning

confidence: 99%

Chemical Defoliant Promotes Leaf Abscission by Altering ROS Metabolism and Photosynthetic Efficiency in Gossypium hirsutum

Jin

Wang

et al. 2020

IJMS

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Chemical defoliation is an important part of cotton mechanical harvesting, which can effectively reduce the impurity content. Thidiazuron (TDZ) is the most used chemical defoliant on cotton. To better clarify the mechanism of TDZ promoting cotton leaf abscission, a greenhouse experiment was conducted on two cotton cultivars (CRI 12 and CRI 49) by using 100 mg L −1 TDZ at the eight-true-leaf stage. Results showed that TDZ significantly promoted the formation of leaf abscission zone and leaf abscission. Although the antioxidant enzyme activities were improved, the reactive oxygen species and malondialdehyde (MDA) contents of TDZ increased significantly compared with CK (water). The photosynthesis system was destroyed as net photosynthesis (Pn), transpiration rate (Tr), and stomatal conductance (Gs) decreased dramatically by TDZ. Furthermore, comparative RNA-seq analysis of the leaves showed that all of the photosynthetic related genes were downregulated and the oxidation-reduction process participated in leaf shedding caused by TDZ. Consequently, a hypothesis involving possible cross-talk between ROS metabolism and photosynthesis jointly regulating cotton leaf abscission is proposed. Our findings not only provide important insights into leaf shedding-associated changes induced by TDZ in cotton, but also highlight the possibility that the ROS and photosynthesis may play a critical role in the organ shedding process in other crops.Previous studies have found that ethylene accelerates organ abscission, while auxin inhibits this process [5][6][7][8][9]. Meanwhile, researchers have paid attention to the fact that multiple cell wall-degrading enzymes are activated to dissolve the cell wall and middle lamella of abscission zone, including cellulases, pecticlyases, polygalactosidases [10][11][12]. Some research has found that hydrogen peroxide (H 2 O 2 ) acts downstream from ethylene and plays a role in the cell-wall degradation process in abscission signaling [13,14].Reactive oxygen species (ROS), including H 2 O 2 , superoxide, singlet oxygen, and the hydroxyl radical, are produced in response to environmental stress [13]. Environmental stresses (such as drought, cold stress, salt stress, and pathogen attack) are often accompanied by leaf abscission [15][16][17], but the relationship between stress and abscission is rarely studied. Excessive ROS can damage cellular components, including lipids, protein, and nucleic acids [18]. ROS produced at the abscission zone site play an important role in regulating leaf abscission under drought stress in cassava (Manihot esculenta Crantz) [19]. Recent studies have found that ROS do not work in the fruit abscission zone of olives (Olea europaea L.), but only alter oxidative stress in the abscission zone of leaves and then mediate abscission induced by ethephon [20]. Previous studies have shown that insufficient carbohydrate accumulation and distribution can lead to flower and fruit abscission. For example, carbohydrate stress can induce longan (Dimocarpus longan Lour.) fruit abscissi...

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“…At the cellular level, a large amount of data regards intercellular communications as critical points for tumor formation, development, and treatment resistance [ 17 ]. Moreover, current research on different cancer cells (from lung, pancreas, prostate, bladder, nervous system) shows that tunneling nanotubes (TNTs), exosomes, and gap junctions are involved in this intercellular network [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

MCF7 Spheroid Development: New Insight about Spatio/Temporal Arrangements of TNTs, Amyloid Fibrils, Cell Connections, and Cellular Bridges

Pulze

Congiu

Brevini

et al. 2020

IJMS

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Human breast adenocarcinoma cells (MCF7) grow in three-dimensional culture as spheroids that represent the structural complexity of avascular tumors. Therefore, spheroids offer a powerful tool for studying cancer development, aggressiveness, and drug resistance. Notwithstanding the large amount of data regarding the formation of MCF7 spheroids, a detailed description of the morpho-functional changes during their aggregation and maturation is still lacking. In this study, in addition to the already established role of gap junctions, we show evidence of tunneling nanotube (TNT) formation, amyloid fibril production, and opening of large stable cellular bridges, thus reporting the sequential events leading to MCF7 spheroid formation. The variation in cell phenotypes, sustained by dynamic expression of multiple proteins, leads to complex networking among cells similar to the sequence of morphogenetic steps occurring in embryogenesis/organogenesis. On the basis of the observation that early events in spheroid formation are strictly linked to the redox homeostasis, which in turn regulate amyloidogenesis, we show that the administration of N-acetyl-l-cysteine (NAC), a reactive oxygen species (ROS) scavenger that reduces the capability of cells to produce amyloid fibrils, significantly affects their ability to aggregate. Moreover, cells aggregation events, which exploit the intrinsic adhesiveness of amyloid fibrils, significantly decrease following the administration during the early aggregation phase of neutral endopeptidase (NEP), an amyloid degrading enzyme.

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A Salutary Role of Reactive Oxygen Species in Intercellular Tunnel-Mediated Communication

Cited by 24 publications

References 356 publications

ROS Homeostasis in Abiotic Stress Tolerance in Plants

ROS Homeostasis in Abiotic Stress Tolerance in Plants

Chemical Defoliant Promotes Leaf Abscission by Altering ROS Metabolism and Photosynthetic Efficiency in Gossypium hirsutum

MCF7 Spheroid Development: New Insight about Spatio/Temporal Arrangements of TNTs, Amyloid Fibrils, Cell Connections, and Cellular Bridges

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