A safety screening questionnaire for transcranial magnetic stimulation

Keel, John; Smith, M. J.; Wassermann, Eric M.

doi:10.1016/s1388-2457(00)00518-6

Cited by 537 publications

(331 citation statements)

References 2 publications

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“…A safetyscreening list was administered to check for contraindications [32], and right-handedness (mean±SD, 44±3.0) was established with the Edinburgh Handedness Inventory [33]. Individual motor threshold (MT) from the left primary motor cortex using the thumb movement visualization method was determined (mean±SD, 54.9±8.6) [34].…”

Section: Methodsmentioning

confidence: 99%

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

2008

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Several lines of evidence suggest that the cerebellum may play a role in the regulation of emotion. The aim of this study was to investigate the hypothesis that inhibition of cerebellar function using slow repetitive transcranial magnetic stimulation (rTMS) would lead to increased negative mood as a result of impaired emotion regulation. In a randomized counterbalanced within-subjects design, 12 healthy young right-handed volunteers received 20 min of cerebellar, occipital, or sham 1 Hz rTMS on three separate days. Mood state inventories were acquired prior to and immediately after rTMS and after an emotion regulation task (ERT). In the ERT, participants were instructed to either look at aversive and neutral scenes, or to suppress the negative feelings experienced while watching aversive scenes during which the electroencephalogram (EEG) was recorded. Results showing no changes in baseline-corrected mood were observed immediately after rTMS. However, significant increases in baseline-corrected negative mood following the ERT were reported after cerebellar rTMS exclusively. No effects on the EEG during the ERT were observed. These findings provide support for the view that the cerebellum is implicated in the regulation of emotion and mood, and concur with evidence of cerebellar abnormalities observed in disorders associated with emotion dysregulation. In order to clarify the underlying biological mechanisms involved, more research is needed.

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Section: Methodsmentioning

confidence: 99%

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

2008

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“…In total, 21 participants (10 females) were screened in relation to their suitability for tACS using the TMS safety screening questionnaire (TASS: Keel et al, 2001) and reported not suffering any known mental or neuropsychiatric conditions. Participants' age ranged between 18 and 35 (mean age = 23.71 SD = 4.69) and were randomly allocated to either active tACS or sham stimulation.…”

Section: Participant Selectionmentioning

confidence: 99%

Transcranial alternating current stimulation to the inferior parietal lobe decreases mu suppression to egocentric, but not allocentric hand movements

2017

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Egocentric vs. allocentric perspective during observation of hand movements has been related to self-other differentiation such that movements observed from an egocentric viewpoint have been considered as self-related while movements observed from an allocentric viewpoint have been considered as belonging to someone else. Correlational studies have generally found that egocentric perspective induces greater neurophysiological responses and larger behavioural effects compared to an allocentric perspective. However, recent studies question previous findings by reporting greater () suppression and greater transcranial magnetic stimulation (TMS) induced motor-evoked potentials (MEPs) during observation of allocentric compared to egocentric movements. Furthermore, selfother differentiation has been generally related to activity within the inferior parietal lobe (IPL), but direct evidence for a causal and functional role of IPL in self-other differentiation is lacking. The current study was therefore designed to investigate the influence that IPL exerts on self-other differentiation. To this aim, we measured the impact of individually adjusted alpha-tuned transcranial alternating current stimulation (tACS) applied over IPL on -suppression during hands movement observation from an egocentric and allocentric perspective. Electroencephalography (EEG) was recorded during movement observation before and immediately after tACS. Results demonstrated that tACS decreased -reactivity over sensorimotor (but not visual) regions for egocentric (but not allocentric) movement observation providing direct evidence for a causal involvement of IPL in the observation of selfbut not other-related hands movement.

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“…The experiments conformed to the Declaration of Helsinki and were approved by the ethics committee of the hospital of the Goethe-University of Frankfurt am Main, Germany. All subjects completed the adult safety screen questionnaire (Keel et al, 2001). Nine healthy right-handed (Oldfield, 1971) subjects (mean ( ± SD) age, 26.2 ± 4.3 years; mean ( ± SD) body length, 180.3 ± 7.6 cm; mean ( ± SD) body weight, 80.9±15.1 kg; 6 males) were enrolled.…”

Section: Subjectsmentioning

confidence: 99%

Deleterious Effects of a Low Amount of Ethanol on LTP-Like Plasticity in Human Cortex

Lücke

Heidegger

Röhner

et al. 2014

Neuropsychopharmacol

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Ingesting ethanol (EtOH) at low doses during social drinking is a common human behavior for its facilitating effects on social interactions. However, low-dose EtOH may have also detrimental effects that so far are underexplored. Here we sought to test the effects of lowdose EtOH on long-term potentiation (LTP)-like plasticity in human motor cortex. Previous cellular experiments showed that low-dose EtOH potentiates extrasynaptic GABAAR and reduces NMDAR-mediated currents, processes that would limit the expression of LTP. Paired associative transcranial magnetic stimulation (PAS LTP ) was employed in nine healthy subjects for induction of LTP-like plasticity, indexed by a long-term increase in motor-evoked potential input-output curves. Synaptic a1-GABAAR function was measured by saccadic peak velocity (SPV). Very low doses of EtOH (resulting in blood concentrations of o5 mM) suppressed LTP-like plasticity but did not affect SPV when compared with a placebo condition. In contrast, 1 mg of alprazolam, a classical benzodiazepine, or 10 mg of zolpidem, a non-benzodiazepine hypnotic, decreased SPV but did not significantly affect LTP-like plasticity when compared with placebo. This double dissociation of low-dose EtOH vs alprazolam/zolpidem effects is best explained by the putatively high affinity of EtOH but not alprazolam/zolpidem to extrasynaptic GABAARs and to NMDARs. Findings suggest that enhancement of extrasynaptic GABAARmediated tonic inhibition and/or reduction of NMDAR-mediated neurotransmission by EtOH blocks LTP-like plasticity in human cortex at very low doses that are easily reached during social drinking. Therefore, low-dose EtOH may jeopardize LTP-dependent processes, such as learning and memory formation.

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A safety screening questionnaire for transcranial magnetic stimulation

Cited by 537 publications

References 2 publications

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

The Cerebellum in Emotion Regulation: A Repetitive Transcranial Magnetic Stimulation Study

Transcranial alternating current stimulation to the inferior parietal lobe decreases mu suppression to egocentric, but not allocentric hand movements

Deleterious Effects of a Low Amount of Ethanol on LTP-Like Plasticity in Human Cortex

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