A Route from Glycobiology to Congenital Muscular Dystrophy

Abstract

Most proteins within living organisms contain glycans. Glycan structures can modulate the biological properties and functions of glycoproteins. The major glycans of glycoproteins can be classified into two groups, N-glycans and O-glycans, according to their glycan-peptide linkage regions. This review will give an outline of the O-mannosyl glycans; structure, biosynthesis, function, and pathology.

Biosynthetic Pathway of O-Mannosyl Glycan in Mammals

“…For a discussion on the relationship between abnormal glycosylation and the pathology of muscular dystrophy, see a previous issue (Endo, T., vol.22, No.125, p152-161) (18).…”