Abstract:Neutrophil recruitment to the sites of inflammation involves selectin-mediated rolling followed by chemokine-induced activation and beta2 integrin-mediated arrest. PSGL-1, a ligand for endothelial P-selectin is presented on the tips of neutrophil microvilli. It has been predicted that P-selectin-PSGL-1 bonds form when the microvillus tip approaches the P-selectin expressing substrate to within 70 nm, but this prediction has not been tested experimentally. A PDMS based microfluidic device with a glass substrate… Show more
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