A rotavirus from kittens

Dr, Snodgrass; Angus, KW; Ew, Gray

doi:10.1136/vr.104.10.222-a

Cited by 24 publications

(22 citation statements)

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“…Rotavirus is established as a common cause of gastroenteritis in the young of many species, and has been previously reported to cause both symptomatic and asymptomatic infections in cats (McNulty et al, 1978 ;Chrystie et al, 1979;Snodgrass et al, 1979;Hoshino et al, 1981). In two of these reports (Chrystie et al, 1979;Snodgrass et al, 1979) rotavirus was associated with symptoms of diarrhoea.…”

Section: Isolation Of Feline Rotaviruses and Their Relationship To Humentioning

confidence: 99%

Isolation of Feline Rotaviruses and Their Relationship to Human and Simian Isolates by Electropherotype and Serotype

Birch

Heath

Marshall

et al. 1985

Journal of General Virology

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SUMMARYRotaviruses were detected by electron microscopy in the faecal specimens of six clinically well cats and virus was subsequently isolated from four of them. Analysis of the RNA of the isolates showed the existence of three electrophoretic types characteristic of the 'long' RNA electrophoretic pattern exhibited by rotaviruses. All feline isolates were neutralized only by antiserum to SA11 rotavirus, indicating that these isolates were serotype 3 rotaviruses. Antiserum prepared against a feline strain neutralized all the feline isolates as well as SA 11 but showed no neutralizing activity against human isolates of serotype 1, 2 or 4.

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Section: Isolation Of Feline Rotaviruses and Their Relationship To Humentioning

confidence: 99%

Isolation of Feline Rotaviruses and Their Relationship to Human and Simian Isolates by Electropherotype and Serotype

Birch

Heath

Marshall

et al. 1985

Journal of General Virology

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“…Fig. 1 Comparison of the deduced amino acid sequence of the outer capsid VP8* trypsin cleavage product of VP4 of the Spanish OVR762 strain with P [14] HRV, BRV, and lapine rotavirus strains, and P [15] Lp14 OVR strain. The highly conserved cysteine (*), proline (.…”

Section: Sequence and Phylogenetic Analysesmentioning

confidence: 99%

“…In the late 1970s, an OVR strain (K923), isolated from a diarrheic lamb, was used to study the pathogenicity of OVRs under experimental conditions using gnotobiotic lambs [12][13][14][15]. Subsequently, three additional OVR strains, L-1, L-2, and L-3, were isolated in Japan during an outbreak of diarrhea in a sheep farm [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…The partially characterized OVR strain L-1 was shown to agglutinate erythrocytes and not antigenically related to G3, G4, G5, or G6 rotaviruses [16]. The most well-known OVR strain, Lp14, was isolated from a diarrheic lamb in China in 1981, and belongs to VP6 SGI, VP4 genotype P [15], VP7 serotype G10, and NSP4 genotype E2 (previously genotype A) [5,[18][19][20]. Strain Lp14 has recently been licensed for use as a human vaccine in China (Lanzhou Institute of Biological Products).…”

Section: Introductionmentioning

confidence: 99%

“…Strain Lp14 has recently been licensed for use as a human vaccine in China (Lanzhou Institute of Biological Products). Antigenic analyses of the original K923 strain [12] and three additional OVR strains, LRV1 (SGI), LRV2a (SGI), and LRV2c (SGII), isolated from lamb feces in the United Kingdom, revealed that the OVR strain K923 was SGI, P [15], and G10 like the strain Lp14, while each of the remaining strains possessed unique antigenic properties commonly found in either cows or humans: P6 [1]G3 (LVR1), P8 [11]G6 (LVR2a), and P1A [8]G9 (LRV2c) [3].…”

Section: Introductionmentioning

confidence: 99%

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Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain

Ciarlet

Hoffmann

Lorusso³

et al. 2008

Virus Genes

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An ovine rotavirus (OVR) strain, 762, was isolated from a 30-day-old lamb affected with severe gastroenteritis, in Zaragoza, Spain, and the VP4, VP7, VP6, NSP4, and NSP5/NSP6 genes were subsequently characterized molecularly. Strain OVR762 was classified as a P[14] rotavirus, as the VP4 and VP8* trypsin-cleavage product of the VP4 protein revealed the highest amino acid (aa) identity (94% and 97%, respectively) with that of the P11[14] human rotavirus (HRV) strain PA169, isolated in Italy. Analysis of the VP7 gene product revealed that OVR762 possessed G8 serotype specificity, a type common in ruminants, with the highest degree of aa identity (95-98%) shared with serotype G8 HRV, bovine rotavirus, and guanaco (Lama guanicoe) rotavirus strains. Moreover, strain OVR762 displayed a bovine-like NSP4 (genotype E2) and NSP5/NSP6 (genotype H3), and a VP6 genotype I2, as well as a long electropherotype pattern. This is the first report of a lamb rotavirus with P[14] and G8 specificities, providing additional evidence for the wide genetic and antigenic diversity of group A rotaviruses.

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Human transmission and outbreaks of feline‐like G6 rotavirus revealed with whole‐genome analysis of G6P[9] feline rotavirus

Fukuda,

Kusuhara,

Takai‐Todaka

et al. 2024

Journal of Medical Virology

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Group A rotaviruses (RVAs) are generally highly species‐specific; however, some strains infect across species. Feline RVAs sporadically infect humans, causing gastroenteritis. In 2012 and 2013, rectal swab samples were collected from 61 asymptomatic shelter cats at a public health center in Mie Prefecture, Japan, to investigate the presence of RVA and any association with human infections. The analysis identified G6P[9] strains in three cats and G3P[9] strains in two cats, although no feline RVA sequence data were available for the former. A whole‐genome analysis of these G6P[9] strains identified the genotype constellation G6‐P[9]‐I2‐R2‐C2‐M2‐A3‐N2‐T3‐E3‐H3. The nucleotide identity among these G6P[9] strains exceeded 99.5% across all 11 gene segments, indicating the circulation of this G6P[9] strain among cats. Notably, strain RVA/Human‐wt/JPN/KF17/2010/G6P[9], previously detected in a 3‐year‐old child with gastroenteritis, shares high nucleotide identity (>98%) with Mie20120017f, the representative G6P[9] strain in this study, across all 11 gene segments, confirming feline RVA infection and symptomatic presentation in this child. The VP7 gene of strain Mie20120017f also shares high nucleotide identity with other sporadically reported G6 RVA strains in humans. This suggests that feline‐origin G6 strains as the probable source of these sporadic G6 RVA strains causing gastroenteritis in humans globally. Moreover, a feline‐like human G6P[8] strain circulating in Brazil in 2022 was identified, emphasizing the importance of ongoing surveillance to monitor potential global human outbreaks of RVA.

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A rotavirus from kittens

Cited by 24 publications

References 0 publications

Isolation of Feline Rotaviruses and Their Relationship to Human and Simian Isolates by Electropherotype and Serotype

Isolation of Feline Rotaviruses and Their Relationship to Human and Simian Isolates by Electropherotype and Serotype

Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain

Human transmission and outbreaks of feline‐like G6 rotavirus revealed with whole‐genome analysis of G6P[9] feline rotavirus

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