A role of the norepinephrine system or effort in the interplay of different facets of inhibitory control

Yu, Shijing; Ghin, Filippo; Mückschel, Moritz; Ziemssen, Tjalf; Stock, Ann‐Kathrin; Beste, Christian

doi:10.1016/j.neuropsychologia.2022.108143

Cited by 10 publications

(14 citation statements)

References 69 publications

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“…Importantly, different aspects of information are concomitantly coded in the EEG signal [ 36 , 37 ]. This has been shown to be particularly evident when investigating the interplay of automatic and controlled processes during response selection and inhibition [ 21 , 38 ]. For this reason, we further applied a residue iteration decomposition (RIDE) [ 39 , 40 ], which can dissociate between stimulus-related processing codes and stimulus-response mapping (response selection) codes in separate clusters of activity in the EEG signal (i.e., the S-cluster and the C-cluster, respectively).…”

Section: Introductionmentioning

confidence: 99%

On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder

Ghin

Beste

Stock

2022

JCM

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The behavioral and neural dynamics of response inhibition deficits in alcohol use disorder (AUD) are still largely unclear, despite them possibly being key to the mechanistic understanding of the disorder. Our study investigated the effect of automatic vs. controlled processing during response inhibition in participants with mild-to-moderate AUD and matched healthy controls. For this, a Simon Nogo task was combined with EEG signal decomposition, multivariate pattern analysis (MVPA), and source localization methods. The final sample comprised n = 59 (32♂) AUD participants and n = 64 (28♂) control participants. Compared with the control group, AUD participants showed overall better response inhibition performance. Furthermore, the AUD group was less influenced by the modulatory effect of automatic vs. controlled processes during response inhibition (i.e., had a smaller Simon Nogo effect). The neurophysiological data revealed that the reduced Simon Nogo effect in the AUD group was associated with reduced activation differences between congruent and incongruent Nogo trials in the inferior and middle frontal gyrus. Notably, the drinking frequency (but not the number of AUD criteria we had used to distinguish groups) predicted the extent of the Simon Nogo effect. We suggest that the counterintuitive advantage of participants with mild-to-moderate AUD over those in the control group could be explained by the allostatic model of drinking effects.

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Section: Introductionmentioning

confidence: 99%

On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder

Ghin

Beste

Stock

2022

JCM

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“…The findings described in this section should not be surprising given that cognitive control functions have been demonstrated to be modulated by catecholamines, [20][21][22]25,48,96 which are synthesized, among others, by the LC, the same nucleus severely affected by opioid withdrawal. 17,18 In sum, OUD seems to impair working memory, decision-making, planning and response inhibition but not cognitive flexibility, suggesting a unique profile of cognitive control deficits.…”

Section: Cognitive Control Deficits In Oudmentioning

confidence: 69%

“…The findings described in this section should not be surprising given that cognitive control functions have been demonstrated to be modulated by catecholamines, 20–22,25,48,96 which are synthesized, among others, by the LC, the same nucleus severely affected by opioid withdrawal 17,18 …”

Section: Shared Neurobiological and Cognitive Facets Of Oud And Atvnsmentioning

confidence: 73%

“…Considering that the central point of this article relies on atVNS as a novel potential ADD‐ON treatment for opioid withdrawal, in this section we opted to only examine shared facets modulated by both opioid withdrawal and atVNS. Cognitive control deficits and affective symptoms typical of OUD seem to underlie changes in levels of catecholamines 19–25 . Crucially, these impairments in cognitive control are responsible for relapses and the failure to regain control over drug use 10 .…”

Section: Shared Neurobiological and Cognitive Facets Of Oud And Atvnsmentioning

confidence: 99%

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Regaining control over opioid use? The potential application of auricular transcutaneous vagus nerve stimulation to improve opioid treatment in China

Colzato,

Elmers,

et al. 2023

Addiction Biology

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Opioid use disorder (OUD) is a critical problem in China and is accompanied by depression and deficits in cognitive control. In China, the most successful intervention for OUD is the community drug rehabilitation where methadone maintenance treatment (MMT) plays a key role. Even though methadone for the treatment of OUD can be helpful, it can cause severe somatic side‐effects, which limit its effectivity. Even worse, it can have detrimental effects on cognitive control, which is crucial to regain control over drug intake. Here, we consider the potential use of auricular transcutaneous vagus nerve stimulation (atVNS) as an addition to MMT for opioid withdrawal treatment. Compared to other non‐invasive brain stimulation methods, atVNS also targets the locus coeruleus (LC) important for noradrenaline (NA) synthesis. NA is an essential neurotransmitter impacted in opioid withdrawal and also critically involved in cognitive control processes. Its ADD‐ON to MMT might be a useful mean to improve mood and enhance cognitive control processes impacted in OUD. We discuss the translational advantages of atVNS in China such as the cultural acceptance of the modality of treatment similar to electroacupuncture. Additionally, the wearability of the ear electrode and at‐home self‐administration without intense medical supervision makes of atVNS a useful tool to enhance clinical and cognitive outcomes especially in everyday life situation. We discuss how atVNS can be integrated in tele‐medical health approaches allowing that innovative treatments can widely be disseminated and continued even in situations of restricted medical access.

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“…Although theta band activity has been associated with a range of higher cognitive functions such as working memory, memory encoding, top-down control 27 and social cognition 28 , it has been demonstrated that its activity reflects the need for control that has to be exerted for response inhibition, and is thus critical for flexible goal-directed behavior. Furthermore, theta band activity has been shown to be a key neurophysiological index of the modulation of the level of automaticity in inhibition control 21,27,[29][30][31] and to reflect relevant effects in the task investigated in the current study 32 . Against this background, dedicated analyses are conducted for this frequency band to investigate the interplay of automatic and controlled processes in response inhibition during alcohol intoxication.…”

Section: Alcohol-induced Deficits In Reactive Control Of Response Sel...mentioning

confidence: 83%

Alcohol-induced deficits in reactive control of response selection and inhibition are counteracted by a seemingly paradox increase in proactive control

Stock

Wendiggensen

Ghin

et al. 2023

Sci Rep

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High-dose alcohol intoxication reduces cognitive control, including inhibition. Although inhibition deficits may contribute to the behavioral deficits commonly observed in alcohol use disorder (AUD), many questions about potentially modulating factors have remained unanswered. We examined the effects of experimentally induced high-dose alcohol intoxication (~ 1.1 ‰) on the interplay between controlled vs. automatic response selection and inhibition in healthy young men. A holistic EEG-based theta activity analysis that considered both reactive control during task performance and preceding proactive control processes was run. It revealed a previously unknown seesaw relationship, with decreased reactive control, but paradoxically increased proactive control. Most importantly, alcohol-induced increases in proactive occipital theta band power were associated with reductions in negative alcohol effects on reactive control processes associated with decreased activity in the SMA and medial frontal cortex. Our findings demonstrate that research should not solely focus on immediate effects during task performance. Aside from differential neurobiochemical and neuroanatomical effects of alcohol, it is also conceivable that proactive control may have been recruited in a (secondary) response to compensate for alcohol-induced impairments in reactive control. Against this background, it could be promising to investigate changes in such compensatory mechanisms in pronounced alcohol-associated inhibition deficits, like in AUD patients.

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A role of the norepinephrine system or effort in the interplay of different facets of inhibitory control

Cited by 10 publications

References 69 publications

On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder

On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder

Regaining control over opioid use? The potential application of auricular transcutaneous vagus nerve stimulation to improve opioid treatment in China

Alcohol-induced deficits in reactive control of response selection and inhibition are counteracted by a seemingly paradox increase in proactive control

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