A role of the immune system in the pathogenesis of schizophrenia

Malashenkova, I K; Krynskiy, Sergey; Ogurtsov, Daniil; Мамошина, М. В.; Zakharova, Natalia V.; Ushakov, Vadim L.; Velichkovsky, Boris M.; Didkovsky, Nikolay

doi:10.17116/jnevro201811812172

Cited by 12 publications

(7 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…correlations (a close relationship of pathophysiological signs) were established between severe negative symptoms and one of the informative indicators of innate immunity, namely the activity of leukocyte elastase [87]. A greater severity of negative symptoms and cognitive impairments was revealed with a decrease in the level of regulatory T cells (a decrease in their level contributes to the development of autoimmune reactions in schizophrenia) [88][89][90]. This contradicts some of the work of other years, according to which pronounced psychotic symptoms are "consistent" with a significant distortion of immune indicators [91][92][93].…”

Section: Neurodegenerative Theorymentioning

confidence: 99%

Schizophrenia: a Narrative Review of Etiological and Diagnostic Issues

Осколкова

2022

Consortium Psychiatricum

View full text Add to dashboard Cite

BACKGROUND: Despite the fact that schizophrenia has already been described historically and researched for a long time, this disorder remains unclear and controversial in many respects, including its etiology, pathogenesis, classification, diagnosis, and therapy. METHODS: Literature from the selected sources (elibrary.ru, Russian Science Citation Index and the Russian branch of the Cochrane Library) were searched and analyzed using the diachronic method. Priority was given to reviews, guidelines, and original research on schizophrenia written during the past 10 years. RESULTS: Historically, scientists have described schizophrenia as a single disorder, a group of disorders, or even as a combination of certain syndromes. The polymorphic symptoms and the most typical dynamics of various forms of schizophrenia have been systematized, but neither in Russia nor in other countries have the etiology and pathogenesis been proven. The reasons for the under- and overdiagnosis of schizophrenia cannot cover all possible objective and subjective difficulties arising in the diagnostic process. CONCLUSION: The existing literature shows that the problem of schizophrenia may not be regarded as settled for a long time. This largely depends on the position of society, the development of biological sciences, and the pathomorphosis of the disorder itself. Many aspects of schizophrenia can become clearer and less controversial with systematic studies based on previous data, as well as data obtained using new research methods.

show abstract

Section: Neurodegenerative Theorymentioning

confidence: 99%

Schizophrenia: a Narrative Review of Etiological and Diagnostic Issues

Осколкова

2022

Consortium Psychiatricum

View full text Add to dashboard Cite

show abstract

“…chronic neuroinflammation. It has been proved by examinations of the post-mortem brain, clinical, and genome-wide studies [ 103 – 107 ]. Association of immunological disorders with schizophrenia prognosis [ 108 ] and symptomatology character is being investigated.…”

Section: Section 2 Biomarkers Of Schizophreniamentioning

confidence: 99%

Diagnosis of Schizophrenia Based on the Data of Various Modalities: Biomarkers and Machine Learning Techniques (Review)

Sharaev¹,

Malashenkova²,

Maslennikova³

et al. 2022

Sovrem Tehnol Med

View full text Add to dashboard Cite

Schizophrenia is a socially significant mental disorder resulting frequently in severe forms of disability. Diagnosis, choice of treatment tactics, and rehabilitation in clinical psychiatry are mainly based on the assessment of behavioral patterns, socio-demographic data, and other investigations such as clinical observations and neuropsychological testing including examination of patients by the psychiatrist, self-reports, and questionnaires. In many respects, these data are subjective and therefore a large number of works have appeared in recent years devoted to the search for objective characteristics (indices, biomarkers) of the processes going on in the human body and reflected in the behavioral and psychoneurological patterns of patients. Such biomarkers are based on the results of instrumental and laboratory studies (neuroimaging, electro-physiological, biochemical, immunological, genetic, and others) and are successfully being used in neurosciences for understanding the mechanisms of the emergence and development of nervous system pathologies.

show abstract

“…Through humoral and neurol pathways, peripheral cytokines could cross over blood-brain barrier (BBB), activate microglia, and partake in the processes of synaptic plasticity and neurogenesis [6]. However, excessive peripheral cytokines or chronic microglial activation may harm neurons or oligodendrocyte precursor cells, resulting in the development of schizophrenia [6][7][8]. The relationship between single cytokines and symptoms of schizophrenia, such as the positive symptoms, negative symptoms, and cognition impairment, has been analyzed in numerous studies [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Immune-inflammatory Response System (IRS) / Compensatory Immune-regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia

Gou

Tong

et al. 2022

Preprint

View full text Add to dashboard Cite

Several studies have reported compromised white matter integrity, and that some inflammatory mediators may underlie this functional dysconnectivity in brain of patients with schizophrenia. The immune-inflammatory response system and compensatory immune-regulatory reflex system (IRS/CIRS) are novel biomarkers for exploring the role of immune imbalance in the pathophysiological mechanism of schizophrenia. This study aimed to explore the little-known area regarding the composite score of peripheral cytokines, the IRS/CIRS, and its correlation with white matter integrity and the specific microstructures most affected in schizophrenia. First-episode patients with schizophrenia (FEPS, n = 94) and age- and sex-matched healthy controls (HCs, n = 50) were enrolled in this study. Plasma cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA), and psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). The whole brain white matter integrity was measured by fractional anisotropy (FA) from diffusion tensor imaging (DTI) using a 3-T Prisma MRI scanner. The IRS/CIRS in FEPS was significantly higher than that in HCs (p = 1.5×10− 5) and Cohen’s d effect size was d = 0.74. FEPS had a significantly lower whole-brain white matter average FA (p = 0.032), which was negatively associated with IRS/CIRS (p = 0.029, adjusting for age, gender, years of education, BMI, and total intracranial volume), but not in the HCs (p > 0.05). Among the white matter microstructures, only the cortico-spinal tract was significantly correlated with IRS/CIRS in FEPS (r=-0.543, p = 0.0009). Therefore, elevated IRS/CIRS may affect the white matter in FEPS.

show abstract

A role of the immune system in the pathogenesis of schizophrenia

Cited by 12 publications

References 83 publications

Schizophrenia: a Narrative Review of Etiological and Diagnostic Issues

Schizophrenia: a Narrative Review of Etiological and Diagnostic Issues

Diagnosis of Schizophrenia Based on the Data of Various Modalities: Biomarkers and Machine Learning Techniques (Review)

Correlation of Immune-inflammatory Response System (IRS) / Compensatory Immune-regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia

Contact Info

Product

Resources

About