A role for TLR10 in obesity and adipose tissue morphology

Boutens, Lily; Mirea, Andreea Manuela; Munckhof, Inge van den; Doppenberg-Oosting, Marije; Jaeger, Martin; Hijmans, Anneke; Netea, Mihai G.; Joosten, Leo A. B.; Stienstra, Rinke

doi:10.1016/j.cyto.2018.03.021

Cited by 12 publications

(12 citation statements)

References 29 publications

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“…In humans, obese individuals with polymorphisms in the TLR10 gene displayed reduced macrophage infiltration in the adipose tissue accompanied by low leptin levels and high adiponectin levels in the plasma [123]. Transgenic human TLR10 mice displayed reduced adipocyte size, adipose tissue weight, and lower plasma insulin levels compared with WT mice fed with a HFD [123]. More studies need to assess the value of TLR10 as a therapeutic target in obesity and metabolic syndrome.…”

Section: Tlrs and Obesity-related Metabolic Diseasesmentioning

confidence: 99%

Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

et al. 2019

Mediators of Inflammation

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Obesity-induced chronic inflammation is known to promote the development of many metabolic diseases, especially insulin resistance, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerosis. Pattern recognition receptor-mediated inflammation is an important determinant for the initiation and progression of these metabolic diseases. Here, we review the major features of the current understanding with respect to obesity-related chronic inflammation in metabolic tissues, focus on Toll-like receptors and nucleotide-binding oligomerization domain-like receptors with an emphasis on how these receptors determine metabolic disease progression, and provide a summary on the development and progress of PRR antagonists for therapeutic intervention.

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Section: Tlrs and Obesity-related Metabolic Diseasesmentioning

confidence: 99%

Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

et al. 2019

Mediators of Inflammation

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“…71 Transgenic mice expressing human TLR10 and fed a highfat diet have smaller adipocytes, less adipose tissue and marginally smaller plasma insulin levels than wild-type animals, suggesting that TLR10 impacts adipose tissue morphology and inflammation during obesity. 77 All these studies suggest that TLR10 can inhibit inflammation.…”

Section: Is Tlr10 the Only Inhibitor Tlr?mentioning

confidence: 99%

“…reading frame (hTLR10-ORF) in the ROSA26-locus, 24,77 or CMV-FLAG-TLR10 plasmid. 43 These obtained vectors were transfected into the mice cell line.…”

Section: T a B L E 3 (Continued)mentioning

confidence: 99%

“…To explore the potential function of TLR10 in vivo, the constitutive human TLR10 knock‐in mouse was generated using targeted transgenesis. Human TLR10‐transgenic (hTLR10tg) mice were generated by inserting an human TLR10 open reading frame (hTLR10‐ORF) in the ROSA26‐locus, 24,77 or CMV‐FLAG‐TLR10 plasmid 43 . These obtained vectors were transfected into the mice cell line.…”

Section: Application Of Tlr10 Transgenic Micementioning

confidence: 99%

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TLR10: Insights, controversies and potential utility as a therapeutic target

Lin

Deng

et al. 2020

Scand J Immunol

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The Toll-like receptor (TLR) family acts as a bridge connecting innate and acquired immunity. TLR10 remains one of the least understood members of this family. Some studies have examined TLR10 ligands, dimerization of TLR10 with other TLRs, and downstream signalling pathways and functions, but they have often arrived at conflicting conclusions. TLR10 can induce the production of proinflammatory cytokines

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“…TLR10 gene was found to have an impact on adipose tissue morphology in obesity. The authors recommended further studies in humans to assess its potential value as therapeutic target in metabolic syndrome and type 2 diabetes (49).…”

Section: Tlr10 As a Target In Therapeutics And Diagnosticsmentioning

confidence: 99%

TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics

et al. 2020

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TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an "orphan receptor" but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.

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A role for TLR10 in obesity and adipose tissue morphology

Cited by 12 publications

References 29 publications

Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

TLR10: Insights, controversies and potential utility as a therapeutic target

TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics

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