A role for the subiculum in the brain motivation/reward circuitry

Cooper, Donald; Klipec, William D.; Fowler, Melissa; Ozkan, Emin D.

doi:10.1016/j.bbr.2006.05.036

Cited by 40 publications

(29 citation statements)

References 49 publications

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“…The effect of the outcomes increasing riskseeking involved the subgenual ACC, a target of the midbraindopaminergic pathway (Haber et al, 2006) heavily connected with the nucleus-accumbens (Johansen-Berg et al, 2008), and the subiculum. The latter structure, by connecting the hippocampus and the rewardcircuitry, activates the dopamine system to highlight the reinforcing properties of rewarding stimuli (Cooper et al, 2006). Importantly, these regions were also more strongly activated by final risky, compared with non-risky, decisions ( Fig.…”

Section: Discussionmentioning

confidence: 96%

Learning from other people's experience: A neuroimaging study of decisional interactive-learning

et al. 2011

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Section: Discussionmentioning

confidence: 96%

Learning from other people's experience: A neuroimaging study of decisional interactive-learning

et al. 2011

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“…The hippocampus has been firmly established in playing a critical role in learning and memory (77), regulating the brain's response to stress (78) and modulating the mesolimbic and mesocortical dopamine reward and motivation circuitries (79,80), which all may make contribution to the mechanisms of depressive behaviors (16,81). Because dendritic spines represent the major postsynaptic compartment for excitatory synaptic inputs, changes in the structure and number of dendritic spines may alter the functional activity of hippocampal neurons.…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor-dependent Spinogenesis Underlies Antidepressant-like Effects of Enriched Environment

Huang

Yang

Huang

2012

Journal of Biological Chemistry

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“…Cocaine also acts as a powerful local anesthetic through a direct effect on voltage-gated sodium channels. Recent work by Cooper et al (2006) suggests that the effect of cocaine on sodium channels in the subiculum may alter cocaine reinstatement. Both preclinical (DC Cooper et al, unpublished observation) and clinical (Adinoff et al, 2001) studies further suggest that neural activation by other sodium channel-mediated local anesthetics (ie procaine, lidocaine) is an attenuated effect following chronic cocaine administration.…”

Section: Non-dopaminergic Effects Of Cocaine On Achmentioning

confidence: 99%

The Role of Acetylcholine in Cocaine Addiction

Williams

Adinoff²

2007

Neuropsychopharmacol

160

138

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Central nervous system cholinergic neurons arise from several discrete sources, project to multiple brain regions, and exert specific effects on reward, learning, and memory. These processes are critical for the development and persistence of addictive disorders. Although other neurotransmitters, including dopamine, glutamate, and serotonin, have been the primary focus of drug research to date, a growing preclinical literature reveals a critical role of acetylcholine (ACh) in the experience and progression of drug use. This review will present and integrate the findings regarding the role of ACh in drug dependence, with a primary focus on cocaine and the muscarinic ACh system. Mesostriatal ACh appears to mediate reinforcement through its effect on reward, satiation, and aversion, and chronic cocaine administration produces neuroadaptive changes in the striatum. ACh is further involved in the acquisition of conditional associations that underlie cocaine self-administration and context-dependent sensitization, the acquisition of associations in conditioned learning, and drug procurement through its effects on arousal and attention. Long-term cocaine use may induce neuronal alterations in the brain that affect the ACh system and impair executive function, possibly contributing to the disruptions in decision making that characterize this population. These primarily preclinical studies suggest that ACh exerts a myriad of effects on the addictive process and that persistent changes to the ACh system following chronic drug use may exacerbate the risk of relapse during recovery. Ultimately, ACh modulation may be a potential target for pharmacological treatment interventions in cocaine-addicted subjects. However, the complicated neurocircuitry of the cholinergic system, the multiple ACh receptor subtypes, the confluence of excitatory and inhibitory ACh inputs, and the unique properties of the striatal cholinergic interneurons suggest that a precise target of cholinergic manipulation will be required to impact substance use in the clinical population.

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A role for the subiculum in the brain motivation/reward circuitry

Cited by 40 publications

References 49 publications

Learning from other people's experience: A neuroimaging study of decisional interactive-learning

Learning from other people's experience: A neuroimaging study of decisional interactive-learning

Vascular Endothelial Growth Factor-dependent Spinogenesis Underlies Antidepressant-like Effects of Enriched Environment

The Role of Acetylcholine in Cocaine Addiction

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