A role for the ribosome in development

Byrne, Mary E.

doi:10.1016/j.tplants.2009.06.009

Cited by 246 publications

(246 citation statements)

References 90 publications

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“…1), showing high levels of expression in tissues with active division, in accordance with the expression patterns of other Arabidopsis ribosomal proteins (Van Lijsebettens et al, 1994;Williams and Sussex, 1995;Weijers et al, 2001;Vanderhaeghen et al, 2006;Bonham-Smith, 2008a, 2008b;Byrne, 2009). Homozygous rpl10B mutant plants exhibit an abnormal phenotype with alterations in vegetative and reproductive growth (Fig.…”

Section: Discussionsupporting

confidence: 68%

“…ethz.ch). Although RPL10B transcript levels were consistently lower than those of RPL10A and RPL10C, this gene is highly regulated during development: its expression profile is similar to other characterized Arabidopsis ribosomal proteins, such as RPS5A and RPS5B (Weijers et al, 2001), RPS18A to RPS18C (Van Lijsebettens et al, 1994;Vanderhaeghen et al, 2006), RPL23aA and RPL23aB Bonham-Smith, 2008a, 2008b), and RPL11A and RPL11B (Williams and Sussex, 1995), where transcripts accumulate to the highest levels in mitogenic tissues and the lowest in nondividing tissues (Byrne, 2009). …”

Section: Expression Of Rpl10 Transcripts In Arabidopsis and Maizementioning

confidence: 82%

“…Mutations in ribosomal proteins have been reported as showing abnormalities in growth and development (Van Lijsebettens et al, 1994;Ito et al, 2000;Weijers et al, 2001;Nishimura et al, 2005;Degenhardt and Bonham-Smith, 2008a;Imai et al, 2008, Pinon et al, 2008Yao et al, 2008;Byrne, 2009;Fujikura et al, 2009;Rosado et al 2010). As mentioned above, homozygous rpl10B plants were significantly underrepresented.…”

Section: Identification and Characterization Of Rpl10 Arabidopsis Insmentioning

confidence: 99%

“…Furthermore, it has been recently demonstrated that QM confers protection against oxidative damage (Chen et al, 2006). Ribosomal protein genes exist as families of multiple expressed members that could be incorporated in the cytosolic ribosome under specific situations, such as certain developmental stages, tissues, and stress conditions (Schmid et al, 2005;Byrne, 2009). In the Arabidopsis (Arabidopsis thaliana) genome, 249 genes have been identified that encode 80 families of cytosolic ribosomal proteins (Barakat et al, 2001).…”

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confidence: 99%

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Plant L10 Ribosomal Proteins Have Different Roles during Development and Translation under Ultraviolet-B Stress

et al. 2010

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(J.B., A.L.B.) Ribosomal protein L10 (RPL10) proteins are ubiquitous in the plant kingdom. Arabidopsis (Arabidopsis thaliana) has three RPL10 genes encoding RPL10A to RPL10C proteins, while two genes are present in the maize (Zea mays) genome (rpl10-1 and rpl10-2). Maize and Arabidopsis RPL10s are tissue-specific and developmentally regulated, showing high levels of expression in tissues with active cell division. Coimmunoprecipitation experiments indicate that RPL10s in Arabidopsis associate with translation proteins, demonstrating that it is a component of the 80S ribosome. Previously, ultraviolet-B (UV-B) exposure was shown to increase the expression of a number of maize ribosomal protein genes, including rpl10. In this work, we demonstrate that maize rpl10 genes are induced by UV-B while Arabidopsis RPL10s are differentially regulated by this radiation: RPL10A is not UV-B regulated, RPL10B is down-regulated, while RPL10C is up-regulated by UV-B in all organs studied. Characterization of Arabidopsis T-DNA insertional mutants indicates that RPL10 genes are not functionally equivalent. rpl10A and rpl10B mutant plants show different phenotypes: knockout rpl10A mutants are lethal, rpl10A heterozygous plants are deficient in translation under UV-B conditions, and knockdown homozygous rpl10B mutants show abnormal growth. Based on the results described here, RPL10 genes are not redundant and participate in development and translation under UV-B stress.

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Section: Discussionsupporting

confidence: 68%

Section: Expression Of Rpl10 Transcripts In Arabidopsis and Maizementioning

confidence: 82%

Section: Identification and Characterization Of Rpl10 Arabidopsis Insmentioning

confidence: 99%

mentioning

confidence: 99%

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Plant L10 Ribosomal Proteins Have Different Roles during Development and Translation under Ultraviolet-B Stress

et al. 2010

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“…The importance of the translational machinery is reflected in the effect that many mutations in ribosomal proteins have on leaf development (for review, see Byrne, 2009;Horiguchi et al, 2012). For instance, Arabidopsis RPS13A encodes a 40S ribosomal protein S13 involved in early leaf development.…”

Section: Protein Synthesis Is Negatively Correlated To Leaf Growthmentioning

confidence: 99%

Combined Large-Scale Phenotyping and Transcriptomics in Maize Reveals a Robust Growth Regulatory Network

et al. 2016

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Leaves are vital organs for biomass and seed production because of their role in the generation of metabolic energy and organic compounds. A better understanding of the molecular networks underlying leaf development is crucial to sustain global requirements for food and renewable energy. Here, we combined transcriptome profiling of proliferative leaf tissue with indepth phenotyping of the fourth leaf at later stages of development in 197 recombinant inbred lines of two different maize (Zea mays) populations. Previously, correlation analysis in a classical biparental mapping population identified 1,740 genes correlated with at least one of 14 traits. Here, we extended these results with data from a multiparent advanced generation intercross population. As expected, the phenotypic variability was found to be larger in the latter population than in the biparental population, although general conclusions on the correlations among the traits are comparable. Data integration from the two diverse populations allowed us to identify a set of 226 genes that are robustly associated with diverse leaf traits. This set of genes is enriched for transcriptional regulators and genes involved in protein synthesis and cell wall metabolism. In order to investigate the molecular network context of the candidate gene set, we integrated our data with publicly available functional genomics data and identified a growth regulatory network of 185 genes. Our results illustrate the power of combining in-depth phenotyping with transcriptomics in mapping populations to dissect the genetic control of complex traits and present a set of candidate genes for use in biomass improvement

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REBELOTE, a regulator of floral determinacy in Arabidopsis thaliana, interacts with both nucleolar and nucleoplasmic proteins

et al. 2018

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The nucleoplasm and nucleolus are the two main territories of the nucleus. While specific functions are associated with each of these territories (such as mRNA synthesis in the nucleoplasm and ribosomal rRNA synthesis in the nucleolus), some proteins are known to be located in both. Here, we investigated the molecular function of REBELOTE ( RBL ), an Arabidopsis thaliana protein previously characterized as a regulator of floral meristem termination. We show that RBL displays a dual localization, in the nucleolus and nucleoplasm. Moreover, we used direct and global approaches to demonstrate that RBL interacts with nucleic acid‐binding proteins. It binds to the NOC proteins SWA 2, At NOC 2 and At NOC 3 in both the nucleolus and nucleoplasm, and also to OBE 1 and VFP 3/ ENAP 1. Taking into account the identities of these RBL interactors, we hypothesize that RBL acts both in ribosomal biogenesis and in the regulation of gene expression.

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A role for the ribosome in development

Cited by 246 publications

References 90 publications

Plant L10 Ribosomal Proteins Have Different Roles during Development and Translation under Ultraviolet-B Stress

Plant L10 Ribosomal Proteins Have Different Roles during Development and Translation under Ultraviolet-B Stress

Combined Large-Scale Phenotyping and Transcriptomics in Maize Reveals a Robust Growth Regulatory Network

REBELOTE, a regulator of floral determinacy in Arabidopsis thaliana, interacts with both nucleolar and nucleoplasmic proteins

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