A Role for the Hedgehog Effector Gli1 in Mediating Stent-induced Ureteral Smooth Muscle Dysfunction and Aperistalsis

Janßen, Claudia; Buttyan, Ralph; Seow, Chun Y.; Jäger, Wolfgang; Solomon, Dennis; Fazli, Ladan; Chew, Ben H.; Lange, Dirk

doi:10.1016/j.urology.2017.01.029

Cited by 16 publications

(28 citation statements)

References 30 publications

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“…Lymphatic obstruction and edematous infiltration due to the tumor mass burden may explain the heterogeneity of these results. Moreover, Janssen et al already suggested some level of cross talk between the two sides that requires further investigation [8]. However, this apparent good result contrasts with the ureteral inflammation with double-pigtail stents and confirms that thinner material is in favour of good mucosa ureteral tolerance.…”

Section: Discussionmentioning

confidence: 93%

“…Janssen at al. described severe intraluminal dilation, scuffed epithelium, and pronounced submucosal edema and inflammation in all ureters when the pigs were fitted with a 6 F double-pigtail stent [8]. Olweny et al observed important edema of the bladder mucosa and fibrosis in the lamina propria at 1 week when Yucatan minipigs were fitted with a 7 F double-pigtail stent [9].…”

Section: Discussionmentioning

confidence: 99%

“…If the thinness of the thread is expected to limit the irritation of the ureter as suggested by the endoscopic appearance, the mechanisms or the local factors involved in the ureteral dilation are still unknown. As Janssen et al suggested, improving our understanding of specific molecular mechanisms leading to stent-associated ureteral dysfunction may identify targets for future therapeutic agents [8].…”

Section: Discussionmentioning

confidence: 99%

“…ere are few studies on the interactions between the ureteral stent and the ureter, especially the human one. Several studies showed a marked ureteral inflammatory reaction when pigs were fitted with double-pigtail stents [7][8][9]. With the MiniJFil ® , the absence of the inflammation of the ureteral mucosa in endoscopy motivated the decision to explore the ureteral histology.…”

Section: Introductionmentioning

confidence: 99%

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Histological Inflammation in Human Ureter either Healthy or Fitted with Double-Pigtail Stent or a Thin 0.3 F Suture Thread: A Preliminary Study

Vogt¹,

Chokri²

2020

Advances in Urology

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Background. Ureteral stent intolerance reduces patients’ quality of life. It has been suggested that changes in the shape of stents could decrease discomfort. In previous studies, the innovative pigtail-suture stent (i.e., JFil® or MiniJFil®) with a thin 0.3 F suture thread significantly decreased stent-related symptoms. Fortuitously, a dilation of the ureter containing the sutures was discovered. In addition, no inflammation was seen on the ureter wall around the suture in endoscopy. In this preliminary study, we assessed ureteral inflammation in the human ureter when it was healthy or when fitted with a double-pigtail stent or a thread. Materials and Methods. After consent and inclusion of patients in the protocol, fifteen segments of ureters were collected during cystectomy procedures for bladder tumors. Ureteral inflammation was assessed on the histological section stained with hematoxylin-eosin. Histological grading (cumulative range of 0 to 6) assessing inflammation was performed on the ureter section for mucosa inflammation and inflammation in the muscle layer. Results. A marked ureteral inflammatory reaction was observed in all cases of ureters fitted with a double-pigtail stent with a mean inflammation score of 4.8 ± 0.4. The ureter fitted with the thin suture thread showed inflammation in only one case with a mean inflammation score of 1.8 ± 1.3 p=0.001. Conclusion. Although the study was limited by the small number of patients, it confirmed that the double-pigtail stent induced ureteral inflammation in all cases and the thin 0.3 F suture thread caused less ureteral inflammation than the double-pigtail stent. The concept of material reduction within the urinary tract seems necessary in order to decrease mucosal irritation. The JFil® or the MiniJFil® thread could meet this requirement.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histological Inflammation in Human Ureter either Healthy or Fitted with Double-Pigtail Stent or a Thin 0.3 F Suture Thread: A Preliminary Study

Vogt¹,

Chokri²

2020

Advances in Urology

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“…A questo fenomeno corrisponde a livello molecolare una progressiva riduzione dell’espressione di Gli-1 nel muscolo liscio, che regredisce dopo la rimozione dello stent. 48 Infine la presenza di uno stent può implicare una sintomatologia dolorosa, più o meno grave, conseguente all’irritazione dell’urotelio a contatto con un corpo estraneo e ai movimenti dello stent nell’uretere e nella vescica.…”

Section: Trattamento Della Calcolosi Ureterale Con Ostruzione Ureteraleunclassified

Tempestività di intervento nella colica renale: aspetti fisiopatologici

Trinchieri

Montanari

2018

Giornale di Tecniche Nefrologiche e Dialitiche

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Methodology for the Development and Validation of New Stent Designs: In Vitro and In Vivo Models

et al. 2022

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The urinary tract is a highly complex, dynamic and variable environment that renders the development of urinary stents extremely challenging. It is mandatory that previous to clinical trials, innovations in urinary medical devices are tested in a preclinical context. The steps of translational research in this regard include in silico, in vitro, ex vivo and in vivo assessments. In this chapter, a critical review of the in vitro stent assessment models is performed, outlining briefly their strengths and weaknesses. Subsequently, a discussion concerning the available animal models for urinary stent evaluation is made with the aim of providing a critical guide for experimental preclinical evaluation of urological devices.

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A Role for the Hedgehog Effector Gli1 in Mediating Stent-induced Ureteral Smooth Muscle Dysfunction and Aperistalsis

Cited by 16 publications

References 30 publications

Histological Inflammation in Human Ureter either Healthy or Fitted with Double-Pigtail Stent or a Thin 0.3 F Suture Thread: A Preliminary Study

Histological Inflammation in Human Ureter either Healthy or Fitted with Double-Pigtail Stent or a Thin 0.3 F Suture Thread: A Preliminary Study

Tempestività di intervento nella colica renale: aspetti fisiopatologici

Methodology for the Development and Validation of New Stent Designs: In Vitro and In Vivo Models

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