A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

Grewe, Markus; Bruijnzeel-Koomen, Carla A.F.M.; Schöpf, Erwin; Thepen, Theo; Langeveld-Wildschut, A.; Ruzicka, Thomas; Krutmann, Jean

doi:10.1016/s0167-5699(98)01285-7

Cited by 661 publications

(531 citation statements)

References 41 publications

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“…In eczema, at least, there is evidence to support a Th2-mediated response, and Th1 and Th2 responses are reciprocal. 31 This study was the first to investigate associations between PBC and various lifestyle factors. We found that PBC was associated with increased odds of ever smoking (current and past; cigarettes, cigars, and pipes) as well as with smoking for over 20 years.…”

Section: Discussionmentioning

confidence: 99%

An exploratory population-based case-control study of primary biliary cirrhosis

et al. 2000

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Primary biliary cirrhosis (PBC) is a disease of unknown etiology, with unexplained geographical variation. Various exposures have been suggested as triggers for disease development-possibly in susceptible individuals, but the evidence was not always well founded. We therefore conducted a population-based case-control study in Northeast England to investigate these and other exposures. All cases incident during 1993 to 1995 in a defined area of Northeast England were identified, and age-and sex-matched population controls were identified from primary care population registers. Cases and controls were sent postal selfcompletion questionnaires covering medical history and lifestyle. Information was received from 100 cases and 223 controls. The familial tendency of PBC was found to be less marked than has been claimed: Only weak associations were found with other autoimmune diseases. Among factors considered previously, no significant associations were found with surgical procedures, events in pregnancy, past infections, vaccinations, and medications. No significant associations were found for previously unconsidered lifestyle factors (drinking alcohol, previous pets, or stressful events), but there was an unexpected association with past smoking (ever smoked: 76% in cases vs. 57% in controls, odds ratio 2.4; smoked for 20 years or more: 64% vs. 35%, odds ratio 3.5). There were also unexpected significant associations with psoriasis (13% in cases vs. 3% in controls, odds ratio 4.6) and eczema (3% in cases vs. 11% in controls, odds ratio 0.13). These findings merit further investigation.

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Section: Discussionmentioning

confidence: 99%

An exploratory population-based case-control study of primary biliary cirrhosis

et al. 2000

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“…T-cell expression of IL-4, IL-5, and IL-13 is significantly upregulated in both acute and chronic AD lesions, as compared to nonlesional AD skin and healthy skin (35,36). Based on atopy patch testing using house dust mite allergens, a biphasic model of cytokine expression by T cells in AD was observed: an initial increase in the infiltration of IL-4 + T cells into AD lesions, followed by infiltration of IFN-γ + T cells in the chronic phase (37). T-cell activities in AD are directed by specialized DCs in the skin including epidermal Langerhans cells and inflammatory dendritic epidermal cells.…”

Section: Adaptive Immunity: Perpetrator Of Persistent and Chronic Infmentioning

confidence: 99%

New insights in the pathogenesis of atopic dermatitis

Ong

2013

Pediatr Res

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“…T cells and eosinophils are thought to play a major role in the pathogenesis of this disease. The skin lesion in AD reveals a mononuclear cell infiltrate consisting of activated CD4 ϩ T cells expressing IL-4, IL-5, and IL-13 mRNA and protein (1). Most patients have increased serum levels of IgE Ab against many kinds of allergens (2).…”

Section: Development Of Atopic Dermatitis-like Skin Lesions In Stat6-mentioning

confidence: 99%

Development of Atopic Dermatitis-Like Skin Lesions in STAT6-Deficient NC/Nga Mice

Yagi

Nagai

Iigo

et al. 2002

The Journal of Immunology

122

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Atopic dermatitis (AD) is a pruritic inflammatory skin disease characterized by elevation of plasma levels of total IgE, infiltration of mast cells and eosinophils, and the expression of cytokines by Th2 T cells. However, the role of Th2 cells in the pathogenesis of AD is not fully understood. In this study we examined the NC/Nga (NC) mouse model of AD and established STAT6-deficient (SATA6−/−) NC mice to investigate the relevance of IL-4-mediated immune responses. Surprisingly, these mice elicited AD-like skin lesions at equivalent frequency and time of onset compared with normal NC littermates. Histological features of the lesion in STAT6−/− NC mice fulfilled the criteria for the pathogenesis of AD, although these mice fail to produce IgE and Th2 cytokines. The lymph nodes proximal to the regions of skin that developed lesions exhibited massive enlargement elicited by the accumulation of activated IFN-γ-secreting T cells. Moreover, caspase I, IL-18, IL-12, and IFN-γ are found to be highly expressed at the skin lesion, occurring simultaneously with elevation of eotaxin 2 and CCR3 expression. Therefore, the Th2-mediated immune response is not necessary for the development of AD-like skin disease in NC mice. The skin microenvironment that favored IFN-γ production tightly correlates with the skin disease in NC mice through the infiltration of eosinophils.

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A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

Cited by 661 publications

References 41 publications

An exploratory population-based case-control study of primary biliary cirrhosis

An exploratory population-based case-control study of primary biliary cirrhosis

New insights in the pathogenesis of atopic dermatitis

Development of Atopic Dermatitis-Like Skin Lesions in STAT6-Deficient NC/Nga Mice

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