A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models

Sniekers, Y.H.; Intema, F.; Lafeber, Floris P. J. G.; Osch, Gerjo J. V. M. van; Leeuwen, Johannes P.T.M. van; Weinans, Harrie; Mastbergen, S.C.

doi:10.1186/1471-2474-9-20

Cited by 124 publications

(120 citation statements)

References 39 publications

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“…The early reduction in plate thickness is in concurrence with a previously published pilot study that demonstrated that subchondral plate thinning at 3 and 10 weeks of OA development even may precede cartilage damage. (13) Also, others have demonstrated that plate thinning is an early feature in the OA process. (15,36) Unfortunately, in our study group, size and variation in bone and cartilage parameters were too small to perform meaningful correlations between values of plate thickness and cartilage degeneration for each group.…”

Section: Discussionmentioning

confidence: 99%

“…Do these early changes normalize over time, or are they the necessary trigger resulting in subchondral sclerosis? Although a short longitudinal pilot study has been performed, (13) it is clear that longer follow-up studies for both models are needed. Do latestage plate thickening and increase in trabecular volume also develop in the groove model, or is it a consequence of the early decrease in trabecular volume parameters seen only in the ACLT model?…”

Section: Discussionmentioning

confidence: 99%

“…In established OA, studies of bone of existing noninvasive (in vivo) analytic methods of subchondral bone changes is low, and small changes are difficult to quantify. (8) Several studies in the rabbit and canine anterior cruciate ligament transaction (ACLT) model of OA (9) showed a decrease of trabecular bone volume (10)(11)(12)(13) and a thinning of the subchondral plate (13)(14)(15) early in the disease process. These changes are in contrast to those found in human end-stage OA.…”

Section: Introductionmentioning

confidence: 99%

“…(13) As such, trabecular bone changes would be unrelated to cartilage pathology. However, this study was limited in number of animals and used a unilateral variant of both models with potential altered loading in control joints owing to the presence of OA in the contralateral joint.…”

Section: Introductionmentioning

confidence: 99%

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Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

Intema

Sniekers

Weinans

et al. 2010

Journal of Bone and Mineral Research

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In osteoarthritis (OA), cartilage degradation is accompanied by subchondral bone changes. The pathogenesis and physiology of bone changes in OA are still unclear. The changes in subchondral bone architecture and cartilage damage were compared in differently induced experimental models of OA. Experimental OA was induced bilaterally by anterior cruciate ligament transection (ACLT) or by cartilage trauma (Groove model); bilateral sham surgery served as control. Lysylpyridinoline (LP, bone resorption) and C-telopeptide of type II collagen (CTX-II, cartilage breakdown) were measured over time. At 20 weeks after surgery, the subchondral cortical plate and trabecular bone of the tibia were analyzed by micro-computed tomography (mCT) and cartilage degeneration was analyzed histologically and biochemically. In both models, cartilage degeneration and cortical subchondral plate thinning were present. CTX-II levels were elevated over time in both models. Subchondral trabecular bone changes were observed only in the ACLT model, not in the Groove model. Correspondingly, LP levels were elevated over time in the ACLT model and not in the Groove model. Interestingly, the trabecular bone changes in the ACLT model were extended to the metaphyseal area. The early decrease in plate thickness, present in both models, as was cartilage damage, suggests that plate thinning is a phenomenon that is intrinsic to the process of OA independent of the cause/induction of OA. On the other hand, trabecular changes in subchondral and metaphyseal bone are not part of a common pathway of OA development and may be induced biomechanically in the destabilized and less loaded ACLT joint. ß

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

Intema

Sniekers

Weinans

et al. 2010

Journal of Bone and Mineral Research

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“…Indeed, Jacobsen et al (2007) showed that the reduction of intra-articular space in the hip was correlated with the decrease in mineral density of sub-chondral bone in postmenopausal women. It was suggested that the alteration of bone structure can cause changes in the load distribution within the joint and promote the development of OA (Sniekers et al 2008). In this case, the favorable effect of estrogen on cartilage may be due in part to the anti-resorption effect of 17-E2 on bone.…”

Section: Sub-chondral Bone Regulationmentioning

confidence: 99%

Estrogens Involvement in the Physiopathology of Articular Cartilage

Moslemi¹,

Demoor²,

Boumediene³

et al. 2011

Challenges in Rheumatology

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Nondestructive, Epi‐Illumination Surface Microscopic Characterization of Surface Discontinuity in Bone: A New Approach Offers a Descriptive Vocabulary and New Insights

Rothschild

2013

The Anatomical Record

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Perspectives are in the eye of the beholder and are expanded with increased scrutiny (e.g., magnification). The term "porosity' for macroscopically or radiologically identifiable discontinuity in bone is so variably applied as to be incomprehensible in its meanings. A closer examination of surface discontinuity seems appropriate. Histological and atomic level analysis of bone alterations misses the forest for the trees and the former destroys the very subject it attempts to characterize. Surface discontinuity was therefore evaluated at the three-dimensional submacroscopic level. An epifluorescent/illumination microscope was used to characterize surface discontinuity in intact specimens of known pathophysiology and/or derivation. The derived perspectives were then utilized to characterize other surface discontinuity. The smooth boundaries of vascular foramen and internal bifurcation, continuity of the expanded base of nerve structures and surrounding elevated rings of Sharpey fibers are all clearly distinguishable from fronts of resorption in erosive arthritis, serpentine discontinuity associated with infectious processes, specific zones of resorption noted in tuberculosis, and structural bone exposure by taphonomic abrasion. These perspectives allow the bone pathology associated with hematoma to be characterized as accentuated Sharpey fiber insertions; maxillary and sphenoid surface discontinuity, as vascular in origin; and periosteal reaction, as manifest by superficial bifurcating channels and in-growth, similar to healing trephanation. Epi-illumination microscopy bridges macroscopic and histological examination, providing greater understanding of the pathology, at no cost to the integrity of the material studied. It explains a number of observed results, while providing discriminatory descriptions of phenomena for which pathophysiology has not yet been clarified. Anat Rec, 296:580-589,

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A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models

Abstract: Background: This study evaluates changes in peri-articular bone in two canine models for osteoarthritis: the groove model and the anterior cruciate ligament transection (ACLT) model.

Cited by 124 publications

References 39 publications

Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis

Estrogens Involvement in the Physiopathology of Articular Cartilage

Nondestructive, Epi‐Illumination Surface Microscopic Characterization of Surface Discontinuity in Bone: A New Approach Offers a Descriptive Vocabulary and New Insights

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