A Role for Strain Differences in Waveforms of Ultrasonic Vocalizations during Male–Female Interaction

Sugimoto, Hiroki; Okabe, Shota; Kato, Masahiro; Koshida, Nobuyoshi; Shiroishi, Toshihiko; Mogi, Kazutaka; Kikusui, Takefumi; Koide, Tsuyoshi

doi:10.1371/journal.pone.0022093

Cited by 120 publications

(109 citation statements)

References 26 publications

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“…Increases in serotonergic activity were related to the presence of female partners, in that they did not occur in the absence of females, and all of the males in our study showed sexual motivation through production of USVs and investigation of females. As previously reported, squeaks produced by females in the current study were tightly coupled in time and number to females kicking at or abruptly darting away from males (Lupanova and Egorova 2015;Nyby 2001;Sugimoto et al 2011). This supports the hypothesis that female squeaks have an unambiguous meaning for sexually motivated males, signaling acute rejection by females.…”

Section: Discussionsupporting

confidence: 91%

“…Confirming previous reports that squeaks relate to the acute rejection of males, female squeaks and rejection behavior were positively correlated with each other (Spearman's ϭ 0.846, P ϭ 0.001; Fig. 5C; Nyby 2001;Sales 1972;Sugimoto et al 2011;Wang HR et al 2008).…”

Section: Serotonergic Activity Was Elevated In the Ic Of Males Duringsupporting

confidence: 88%

“…Male mice emit copious ultrasonic vocalizations (USVs) in the presence of females, and an increase in the use of a particular structural category of USV, the "harmonic" USV, corresponds in time to bouts of mounting (Hanson and Hurley 2012). Audible squeaks, produced by both sexes during distress, are emitted by females during courtship and have a negative significance for sexually motivated males (Lahvis et al 2011;McGill 1962;Sales 1972), in that squeaks emitted by females are coupled with kicking at males (Lahvis et al 2011;Nyby 2001;Sugimoto et al 2011;Wang HR et al 2008). These vocalizations and other copulatory behaviors show a clear progression over the courtship interaction.…”

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confidence: 99%

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Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship

Keesom

Hurley

2016

Journal of Neurophysiology

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Keesom SM, Hurley LM. Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship. J Neurophysiol 115: 1786 -1796, 2016. First published January 20, 2016 doi:10.1152/jn.00742.2015.-Cues from social partners trigger the activation of socially responsive neuromodulatory systems, priming brain regions including sensory systems to process these cues appropriately. The fidelity with which neuromodulators reflect the qualities of ongoing social interactions in sensory regions is unclear. We addressed this issue by using voltammetry to monitor serotonergic fluctuations in an auditory midbrain nucleus, the inferior colliculus (IC), of male mice (Mus musculus) paired with females, and by concurrently measuring behaviors of both social partners. Serotonergic activity strongly increased in male mice as they courted females, relative to serotonergic activity in the same males during trials with no social partners. Across individual males, average changes in serotonergic activity were negatively correlated with behaviors exhibited by female partners, including broadband squeaks, which relate to rejection of males. In contrast, serotonergic activity did not correlate with male behaviors, including ultrasonic vocalizations. These findings suggest that during courtship, the level of serotonergic activity in the IC of males reflects the valence of the social interaction from the perspective of the male (i.e., whether the female rejects the male or not). As a result, our findings are consistent with the hypothesis that neuromodulatory effects on neural responses in the IC may reflect the reception, rather than the production, of vocal signals.

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Section: Discussionsupporting

confidence: 91%

Section: Serotonergic Activity Was Elevated In the Ic Of Males Duringsupporting

confidence: 88%

mentioning

confidence: 99%

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Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship

Keesom

Hurley

2016

Journal of Neurophysiology

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“…Significance for ratios was evaluated with 1-way ANOVA (and Bonferroni post hoc test). Multivariate analysis of variance (MANOVA) was used to test the effect of strain on the variables studied (Sugimoto et al, 2011). Significance was established at p < 0.05.…”

Section: Discussionmentioning

confidence: 99%

Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models

Ménard

Quirion

Vigneault

et al. 2015

Neurobiology of Aging

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In humans, memory capacities are generally affected with aging, even without any reported neurologic disorders. The mechanisms behind cognitive decline are not well understood. We studied here whether postsynaptic glutamate receptor and presynaptic vesicular glutamate transporters (VGLUTs) levels may change in the course of aging and be related to cognitive abilities using various age-impaired (AI) or age-unimpaired rat strains. Twenty-four-month-old Long-Evans (LE) rats with intact spatial memory maintained postsynaptic ionotropic glutamate receptor levels in the hippocampal-adjacent cortex similar to those of young animals. In contrast, AI rats showed significantly reduced expression of ionotropic glutamate receptor GluR2, NR2A and NR2B subunits. In AI LE rats, VGLUT1 and VGLUT2 levels were increased and negatively correlated with receptor levels as shown by principal component analysis and correlation matrices. We also investigated whether glutamatergic receptors and VGLUT levels were altered in the obesity-resistant LOU/C/Jall (LOU) rat strain which is characterized by intact memory despite aging. No difference was observed between 24-month-old LOU rats and their young counterparts. Taken together, the unaltered spatial memory performance of 24-month-old age-unimpaired LE and LOU rats suggests that intact coordination of the presynaptic and postsynaptic hippocampal-adjacent cortex glutamatergic networks may be important for successful cognitive aging. Accordingly, altered expression of presynaptic and postsynaptic glutamatergic components, such as in AI LE rats, could be considered a marker of age-related cognitive deficits.

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“…The characteristics of mouse USVs change with maturation from pup to adult 26 , and differ across strains 1,20,27 . In addition, the female estrous cycle influences male courtship USVs 28 .…”

Section: Discussionmentioning

confidence: 99%

Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test

Asaba¹,

Kato²,

Koshida³

et al. 2015

JoVE

Self Cite

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Mice emit ultrasonic vocalizations (USVs) during a variety of conditions, such as pup isolation and adult social interactions. These USVs differ with age, sex, condition, and genetic background of the emitting animal. Although many studies have characterized these differences, whether receiver mice can discriminate among objectively different USVs and show preferences for particular sound traits remains to be elucidated. To determine whether mice can discriminate between different characteristics of USVs, a playback experiment was developed recently, in which preference responses of mice to two different USVs could be evaluated in the form of a place preference.First, USVs from mice were recorded. Then, the recorded USVs were edited, trimmed accordingly, and exported as stereophonic sound files. Next, the USV amplitudes generated by the two ultrasound emitters used in the experiment were adjusted to the same sound pressure level. Nanocrystalline silicon thermo-acoustic emitters were used to play the USVs back. Finally, to investigate the preference of subject mice to selected USVs, pairs of two differing USV signals were played back simultaneously in a two-choice test box. By repeatedly entering a defined zone near an ultrasound emitter and searching the wire mesh in front of the emitter, the mouse reveals its preference for one sound over another. This model allows comparing the attractiveness of the various features of mouse USVs, in various contexts. Video LinkThe video component of this article can be found at

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A Role for Strain Differences in Waveforms of Ultrasonic Vocalizations during Male–Female Interaction

Cited by 120 publications

References 26 publications

Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship

Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship

Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models

Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test

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