A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells

Hack, C. Erik; Wolbink, Gertjan; Schalkwijk, C.; Speijer, Han; Hermens, W. Th.; Bosch, H. van den

doi:10.1016/s0167-5699(97)01002-5

Cited by 171 publications

(97 citation statements)

References 43 publications

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“…It has recently been suggested that C-reactive protein binds to LPC in membranes of injured cells, thereby activating the complement cascade. 27 Thus, C-reactive protein, which is elevated in the blood in inflammatory conditions, is a potential candidate for an LPC-complexing protein, a possibility presently under investigation.…”

Section: Discussionmentioning

confidence: 99%

“…27 Clearly, studies of the role of anti-LPC antibodies in chronic inflammation and atherosclerosis could shed light on this issue. Taken together, it is possible that LPC, produced during oxidation or enzymatically by PLA 2 , may activate B cells to antibody secretion and thus participate in and promote the chronic inflammatory reactions seen in atherosclerosis and several types of immunological disorders.…”

Section: Discussionmentioning

confidence: 99%

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Lysophosphatidylcholine Is Involved in the Antigenicity of Oxidized LDL

Huang

Elinder

et al. 1998

ATVB

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Abstract-Lysophosphatidylcholine (LPC) is formed by hydrolysis of PC in low density lipoprotein (LDL) and cell membranes by phospholipase A 2 or by oxidation. Oxidized (ox) LDL activates endothelial cells, an effect mimicked by LPC. oxLDL also has the capacity to activate T and B cells, and antibody titers to oxLDL are related to the degree of atherosclerosis. The antigen in oxLDL responsible for its immune-stimulatory capacity is not well characterized, and we hypothesized that LPC was involved. We demonstrate herein the presence of antibodies against LPC, both of the IgG and IgM isotype, in 210 healthy individuals. This antibody reactivity was not specifically related to oxidation of the fatty acid moiety in LPC, since LPC containing only palmitic acid showed antibody titers equivalent to those of LPC containing unsaturated fatty acids. Antibody titers to PC were low compared with LPC, and hydrolysis of PC at the sn-2 position is thus essential for immune reactivity. There was a close correlation between anti-oxLDL and anti-LPC antibodies. Furthermore, LPC competitively inhibited anti-oxLDL reactivity, which indicates that LPC may explain a significant part of the immune-stimulatory properties of oxLDL. LPC, being a lipid, is not likely to be an antigen itself.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lysophosphatidylcholine Is Involved in the Antigenicity of Oxidized LDL

Huang

Elinder

et al. 1998

ATVB

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“…CRP is an inflammatory marker that can promote the phagocytosis of injured cells and tissue remnants in combination with other proteins, thus increasing inflammation and tissue damage (20). It is hypothesized that periodontitis may alter the lipid profile and CRP levels in obese and normal weight individuals, but controlled clinical studies are still required to clarify these relationships.…”

Section: Introductionmentioning

confidence: 99%

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Zuza¹,

Barroso²,

Fabricio³

et al. 2016

Journal of Oral Science

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Periodontal treatment may improve the metabolic control of dyslipidemia. The aim of this study was to evaluate the lipid profile and high-sensitivity C-reactive protein (hs-CRP) levels in obese and non-obese patients undergoing periodontal therapy. Patients with generalized chronic periodontitis were divided into obese (n = 28) and non-obese groups (n = 26). The periodontal parameters (visible plaque index, gingival bleeding index, probing depth, clinical attachment level, and bleeding on probing), anthropometric measurements (body mass index, waist circumference, and body fat), and serum analyses (triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, fasting glucose, glycated hemoglobin, and hs-CRP) were measured at baseline and 90 days after periodontal treatment. The results showed that the obese subjects presented alterations in triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP at baseline when compared with non-obese patients (P < 0.05). Periodontal treatment could improve the periodontal parameters in both groups similarly (P > 0.05). Obese subjects showed a significant decrease in the levels of triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP post-therapy (P < 0.05), while non-obese patients showed improvement only in hs-CRP (P < 0.05). In conclusion, periodontal treatment could improve the periodontal parameters and circulating hs-CRP in obese and non-obese subjects. Lipid profile was modified only in obese patients post-therapy. (J Oral Sci 58, [423][424][425][426][427][428][429][430] 2016)

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“…Therefore, an elevated CRP signifies ongoing activation of inflammation that characterizes unstable coronary artery disease and may be one of the causal factors of instability. 4 Microalbuminuria even in healthy individuals is a risk factor for chest pain associated with cardiovascular events. The pathophysiologic mechanism underlying the association between albumin excretion and CVD is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Microalbuminuria and C-reactive protein as a predictor of coronary artery disease in patients of acute chest pain

Sharma

Ghalaut

Dixit

et al. 2013

Journal of Cardiovascular Disease Research

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a b s t r a c tMicroalbuminuria is a risk factor for cardiovascular disease. It is gaining importance as a marker of atherogenic milieu and indicates the target organ damage and can be a valuable tool in screening and identification of patients with cardiovascular disease. Markers of inflammation, such as C-reactive protein (CRP), were found to be related to cardiovascular disease (CVD) events in patients with chest pain. In addition, recent studies have shown that, in the case of atherosclerosis, increased levels of CRP, reflects inflammatory condition of vessel wall. In the present study, CRP and microalbuminuria were estimated in patients of acute chest pain. The patients were divided into two study groups (gp-1 patients of chest pain with CVD and gp-2 patients of chest pain of causes other than CVD) along with one healthy control group. It was found that microalbuminuria was higher in CVD patients (RR ¼ 6.250,95% CI 2.346 e16.45,P < 0.05) and also CRP was much higher in CVD patients (RR ¼ 13.667,95% CI 4.528e41.253, P < 0.05) as compared to other two groups. Sensitivity, specificity and positive predictive value of CRP and microalbuminuria were also higher in gp-1 (CVD) patients as compared to other two groups. Therefore, CRP and microalbuminuria can be used as important biomarkers in screening CVD.

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A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells

Abstract: A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells Hack, C.E.; Wolbink, G.J.; Schalkwijk, C.G.; Speijer, H.; Hermens, W.Th.; van den Bosch, H.

Cited by 171 publications

References 43 publications

Lysophosphatidylcholine Is Involved in the Antigenicity of Oxidized LDL

Lysophosphatidylcholine Is Involved in the Antigenicity of Oxidized LDL

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Microalbuminuria and C-reactive protein as a predictor of coronary artery disease in patients of acute chest pain

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