A role for rheumatoid factor enhancement of Plasmodium falciparum schizont inhibition in vitro

Green, T J; Packer, B J

doi:10.1128/iai.46.3.668-672.1984

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…There was a positive and significant correlation between antimalarial antibody titre and the serum level of RF as well as 'protein coefficient'. Some authors [49] have reported that RF is produced during active or chronic malarial infection and that it might contribute non-specifically to the enhanced clearance of plasmodia. It is also well known that chronic exposure to malarial parasites can lead to polyclonal stimulation of immunoglobulin cells and thus to an increased frequency of AAb [50].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of autoantibodies in an elderly sub-Saharan African population

Njemini¹,

Meyers²,

Demanet³

et al. 2002

Clinical and Experimental Immunology

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SUMMARYIn the present prospective, census-based study we have investigated the prevalence of organ-specific and non-organ-specific autoantibodies (AAb) in 152 unselected Cameroonians aged 60 years and older living in the community. AAb were detected in 49% of the participants. Non-organ-specific AAb (47%) predominated over organ-specific AAb (7%). Anti-TPO, anti-Tm, anti-Tg and anti-PC AAb were completely absent. RF was the most frequent AAb, being found in 57 (38%) cases. The prevalences of anti-SMA and RF were significantly higher in women than in men (respectively, P = 0·023 and P = 0·016). Higher serum concentrations of gammaglobulins were accompanied by a higher prevalence of RF (P < 0·0001) and a lower prevalence of ANA (P = 0·036). The overall prevalence of AAb was higher in the filaria-infected (60%) compared to the non-infected (42%) participants (P = 0·046). There was no significant influence of the vitamin D status, number of pregnancies, physical activity or medication use on the prevalence of AAb. In this study a heterogeneous pattern for the presence of the various AAb was found. Some AAb, which are commonly encountered in other studies on elderly subjects, were completely absent in this population. This diversified pattern of AAb prevalence therefore argues in favour of exogenous influences in the occurrence of AAb in elderly populations.

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Section: Discussionmentioning

confidence: 99%

The prevalence of autoantibodies in an elderly sub-Saharan African population

Njemini¹,

Meyers²,

Demanet³

et al. 2002

Clinical and Experimental Immunology

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“…The PIT (Green et al 1981;Green & Packer, 1984) was employed to measure two kinds of inhibition mediated by the MoAbs: (1) their ability to prevent an increase in parasitaemia (growth inhibition, GI) and (2) their ability to prevent the dispersal of merozoites from mature schizonts (schizont inhibition, SI). Parasitized erythrocytes were synchronized to ring stages using 5 % sorbitol (Lambros & Vanderberg, 1979).…”

Section: Parasite Inhibition Test (Pit)mentioning

confidence: 99%

“…A protective role for IgM-RF in immunity to malaria was first demonstrated by Green & Packer (1984), who showed that human RF could enhance the agglutination of P. falciparum merozoites coated with immune human or Aotus monkey IgG by crosslinking the Fc fragments of the parasite-specific antibodies. Removal of the IgM-RF from sera by adsorption against rabbit IgG-coated sheep red blood cells abolished the enhancing effect of the sera.…”

Section: Introductionmentioning

confidence: 99%

Monoclonal IgM rheumatoid factor-like anti-globulins enhance the inhibitory effects ofPlasmodium falciparum-specific monoclonal antibodiesin vitro

Stuart

Green

1990

Parasitology

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Monoclonal IgM rheumatoid factor-like anti-globulins were produced by in vitro stimulation of naive BALB/c spleen cells with lipopolysaccharide, and by hyperimmunization of mice with merozoites of Plasmodium falciparum, followed by fusion of the spleen cells to mouse myelomas. In vitro, these anti-globulins augmented the inhibitory effects of P. falciparum-specific polyclonal mouse sera and monoclonal IgG1 and IgG2b antibodies by binding to Fc fragments of IgG molecules attached to blood-stage parasites. In some instances, the presence of anti-globulins correlated with an increase in the number of schizonts which failed to disperse merozoites. In other cases, parasitaemia remained low in the absence of the schizont inhibition phenomenon, suggesting that anti-globulins contribute to host cell protection not only by agglutinating merozoites, but also by increasing the density of the antibody coat surrounding the parasites, thus interfering with parasite receptor-erythrocyte ligand interactions. The anti-globulins were not inhibitory when added to parasite cultures containing IgG not specific for P. falciparum. These results may help explain the function of IgM anti-globulins found at elevated serum levels in some patients with malaria or other chronic infectious diseases.

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“… Might induction of NeRFa be a future promising method not only against malaria as suggested in Ref. ( 33 ), but also against life-threatening viruses like Ebola ( 34 )? …”

mentioning

confidence: 99%

Neutralization-Enhancing RF Antibodies for HIV Vaccines

Suslov

2014

Front. Immunol.

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A role for rheumatoid factor enhancement of Plasmodium falciparum schizont inhibition in vitro

Cited by 13 publications

References 24 publications

The prevalence of autoantibodies in an elderly sub-Saharan African population

The prevalence of autoantibodies in an elderly sub-Saharan African population

Monoclonal IgM rheumatoid factor-like anti-globulins enhance the inhibitory effects ofPlasmodium falciparum-specific monoclonal antibodiesin vitro

Neutralization-Enhancing RF Antibodies for HIV Vaccines

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