A role for "one-factor-at-a-time" experimentation in parameter design

Frey, Daniel; Engelhardt, Fredrik; Greitzer, E. M.

doi:10.1007/s00163-002-0026-9

Cited by 124 publications

(57 citation statements)

References 22 publications

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“…2. The equation was very reliable with R 2 value of 0.9365 and low p values (p \ 0.1) of the model fit, which indicate a strong correspondence between theoretical predictions and experimental results [11,12]. The low coefficient of variation (CV) value of 7.956054 also represented that the differences between the predicted and the observed values were little.…”

Section: Pbd and Analysismentioning

confidence: 70%

“…However, such traditional optimization strategies (one-factor-at-a-time) require considerable time and effort [12]. More statistical approach such as the Plackett-Burman (PBD) and the Box-Behnken design (BBD) efficiently select the most significant components of the medium and rapidly evaluates the interactions between multiple components [13].…”

Section: Introductionmentioning

confidence: 99%

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Optimization of culture medium for enhanced production of exopolysaccharide from Aureobasidium pullulans

Yoon

Hong

Kim

et al. 2011

Bioprocess Biosyst Eng

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Polysaccharides produced by microorganisms are utilized for a variety of purposes, including the use in cosmetics and as food additives. More recently, polysaccharides have been exploited by the medical and pharmaceutical industries, and those originated from many species of mushrooms have been especially useful in industrial applications; however, the production and synthesis of these compounds is costly and time consuming. In this study, we developed a method for low-cost production of exopolysaccharide (EPS) that effectively screens components and optimizes medium composition using statistical methods (Plackett-Burman and Box-Behnken design). As a result, we obtained the following optimized medium: sucrose 165.73 g/L, sodium nitrate 3.08 g/L, dipotassium phosphate 1.00 g/L, potassium chloride 0.50 g/L, magnesium sulfate 0.50 g/L, ferrous sulfate 0.01 g/L, and 0.71 g/L of Ashbya gossypii extract. The maximum production of about 29 g/L EPS was achieved in the optimized medium during 84 h batch fermentation.

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Section: Pbd and Analysismentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Optimization of culture medium for enhanced production of exopolysaccharide from Aureobasidium pullulans

Yoon

Hong

Kim

et al. 2011

Bioprocess Biosyst Eng

View full text Add to dashboard Cite

show abstract

“…However, this method is timeconsuming, and interaction among the medium component cannot be studied (Mu et al 2009). The limitation of such method can be avoided by using statistical experimental design, a powerful and useful tool, which can allow explaining interactions between the different variables and decreasing the process variability (Frey et al 2003). The most popular choices are the Plackett-Burman design (PBD) and the central composite design (CCD), along with the response surface analysis (Liu et al 2005;Xu et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Statistical physical and nutrient optimization of bioplastic polyhydroxybutyrate production by Cupriavidus necator

Aramvash

Shahabi

Aghjeh

et al. 2015

Int. J. Environ. Sci. Technol.

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Polyhydroxyalkanoates are biodegradable polymer materials that accumulate in numerous bacteria. The polyhydroxybutyrate is the most common type of polyhydroxyalkanoates, which potentially serves as precursor for bioplastic production. The most extensively studied polyhydroxybutyrate producing bacteria is Cupriavidus necator due to its capability to accumulate large amounts of this biopolymer in simple culture medium. Accumulation of polyhydroxyalkanoates granules in the cytoplasm of C. necator significantly depended on pH, aeration, carbon sources, nitrogen sources, and minerals in the culture medium. In the present study, the effect of both nutritional and physical variables on polyhydroxybutyrate production was investigated in order to optimize these conditions. At first, on the basis of one-factor-at-a-time experiments, fructose and ammonium chloride were found to be the most suitable sources of carbon and nitrogen for biopolymer production. Then the most significant factors affecting granules accumulation were recognized as fructose, agitation speed, KH 2 PO 4 , and initial pH using the Plackett-Burman and central composite design. ANOVA analysis showed significant interaction between fructose and agitation speed. After optimization of the medium, compositions for polyhydroxybutyrate production were determined as follows: fructose 35 g/L, KH 2 PO 4 1.75 g/L, MgSO 4 Á7H 2 O 1.2 g/L, citric acid 1.7 g/L, trace element 10 mL/L, initial pH = 7, and agitation speed 175 rpm. Under this optimal culture conditions, the maximum yield of PHB was 7.48 g/L. The present strategies included in this study could be used for PHB production by this bacterium. These results are the highest values of PHB ever obtained from batch culture of C. necator reported so far.

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“…Although OFAT leads to clearly expressed conclusions, the chance of missing optimum conditions and not observing the covariance between parameters is high in this approach. 15,16 Thus, existing results should be interpreted with caution, and the widely accepted hypotheses for the effect of synthesis conditions require further revaluation to be extrapolated to novel practices. In the current work, we present a systematic study of the effect of simultaneous changes of synthesis conditions on surface morphology, and permeation properties of TFC membranes.…”

Section: Introductionmentioning

confidence: 99%

Thin film composite polyamide membranes: parametric study on the influence of synthesis conditions

et al. 2015

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Preparation of thin film composite (TFC) polyamide (PA) membranes by interfacial polymerization (IP) reaction is remarkably sensitive to the interactions between synthesis parameters. Here we report the effect of the simultaneous change in four synthesis parameters, namely monomers concentrations (m-phenylenediamine, MPD, and trimesoyl chloride, TMC), reaction time and curing temperature, on the surface morphology and on the permeation properties of TFC membranes. By varying several synthesis parameters at the same time using a Taguchi robust design (L9 orthogonal arrays), it was found that monomers concentration and curing temperature significantly affected water permeation by creating a substantial change in morphology of the PA films. More importantly, a strong interaction between monomers concentration was observed, which demonstrates the importance of smart adjustment of these parameters in the preparation process. Permeation properties were justified by thickness and by the cross-link density of the synthesized films; the latter was found to be more influential. Based on analysis of variance (ANOVA), the contribution of the synthesis parameters towards change in water permeation was determined as: curing temperature (40.7%) > MPD concentration (28%) $ TMC concentration (27.8%) > reaction time (1.9%). The findings will provide valuable guidelines to develop practical low cost, robust and high performance membranes by changing the curing temperature and the monomer concentrations as critical parameters.

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A role for "one-factor-at-a-time" experimentation in parameter design

Cited by 124 publications

References 22 publications

Optimization of culture medium for enhanced production of exopolysaccharide from Aureobasidium pullulans

Optimization of culture medium for enhanced production of exopolysaccharide from Aureobasidium pullulans

Statistical physical and nutrient optimization of bioplastic polyhydroxybutyrate production by Cupriavidus necator

Thin film composite polyamide membranes: parametric study on the influence of synthesis conditions

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