A role for neutrophils in intermittent allergic rhinitis

Fransson, Mattias; Benson, Mikael; Wennergren, Göran; Cardell, Lars-Olaf

doi:10.1080/00016480310015173

Cited by 28 publications

(20 citation statements)

References 25 publications

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“…In addition, interleukin (IL)-17 is increased in AR patients, which could recruit a large number of neutrophils 18. Fransson et al19 showed a positive correlation between increased neutrophil quantity in nasal secretions and nasal secretion symptom scores. They also stated that both the total nasal symptom scores and secretion scores correlated with the number of neutrophils in lavage fluids after allergen provocation, whose potential mechanism may be the release of proteolytic enzymes (histamine, cathepsin G, and elastase) from neutrophil granules.…”

Section: Discussionmentioning

confidence: 99%

Individualized Treatment of Allergic Rhinitis According to Nasal Cytology

Chen

Zhou

Zhang

et al. 2017

Allergy Asthma Immunol Res

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PurposeNasal cytology is important in the diagnosis and treatment of nasal inflammatory diseases. Treatment of allergic rhinitis (AR) according to nasal cytology has not been fully studied. We plan to explore the individualized treatment of AR according to nasal cytology.MethodsNasal cytology from 468 AR patients was examined for inflammatory cell quantity (grade 0-5) and the percentage of neutrophils and eosinophils. Results were subdivided into the following categories: AR(Eos), eosinophil ≥50% of the whole inflammatory cells; AR(Neu), neutrophils ≥90%; AR(Eos/Neu), 10%≤ eosinophil <50%; AR(Low), grade 0/1 inflammatory cell quantity. Nasal cytology-guided treatment was implemented: all AR(Eos) patients (n=22) and half of the AR(Neu) patients (AR[Neu1], n=22) were treated with mometasone furoate spray and oral loratadine. Another half of the AR(Neu) patients (AR[Neu2], n=22) were treated with oral clarithromycin. Visual analog scale (VAS), symptom scores, and nasal cytology were evaluated 2 weeks before and after treatment.ResultsThere were 224/468 (47.86%) AR(Eos), 67/468 (14.32%) AR(Neu), 112/468 (23.93%) AR(Eos/Neu), and 65/468 (13.89%) AR(Low) of the AR patients studied. There were no significant differences in clinical characteristics among these subgroups, except that the nasal blockage score was higher in AR(Eos) patients than in AR(Neu) patients (1.99 vs 1.50, P=0.02). Comparing AR(Eos) patients with AR(Neu1) patients 2 weeks after treatment, nasal symptoms and VAS were significantly lower in AR(Eos) patients, except for nasal blockage symptoms (P<0.05 of nasal itching and sneezing; P<0.01 for nasal secretion, total scores, and VAS). Comparing AR(Neu1) with AR(Neu2) patients, nasal symptoms, and VAS were significantly lower in AR(Neu2), except for nasal blockage and nasal itching symptoms (P<0.05 for nasal secretions, sneezing, total score, and VAS).ConclusionsNasal cytology may have important value in subtyping AR and optimizing AR treatment. Treating neutrophils is very important in AR patients with locally predominant neutrophils.

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Section: Discussionmentioning

confidence: 99%

Individualized Treatment of Allergic Rhinitis According to Nasal Cytology

Chen

Zhou

Zhang

et al. 2017

Allergy Asthma Immunol Res

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“…Nasal lavage fluid was obtained as previously described [23]. Briefly, after clearing excess mucous by forceful exsufflation, 8–10 ml of sterile saline solution (0.9% NaCl) of RT was aerosolized into each nostril, while clearing the other.…”

Section: Methodsmentioning

confidence: 99%

Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis

et al. 2007

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Background: Allergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood. Toll-like receptor 9 (TLR9) is a receptor for unmethylated CpG dinucleotides found in bacterial and viral DNA. The present study was designed to examine the expression of TLR9 in the nasal mucosa and in leukocytes derived from different cellular compartments during symptomatic allergic rhinitis.

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“…NAL was obtained as previously described [11]. After clearing excess mucous by exsufflation, sterile saline solution (8–10 ml; 0.9% NaCl) at room temperature (RT) was aerosolized into each nostril.…”

Section: Methodsmentioning

confidence: 99%

Systemic Up-Regulation of TLR4 Causes Lipopolysaccharide-Induced Augmentation of Nasal Cytokine Release in Allergic Rhinitis

Ekman¹,

Virtala²,

Fransson³

et al. 2012

Int Arch Allergy Immunol

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Background: Allergic rhinitis is a systemic disorder, and it is clinically well recognized that it can be aggravated by infection. Activation of the innate immune system constitutes a critical element in the process. Toll-like receptors (TLRs) comprise a part of the innate immune system, and lipopolysaccharide (LPS)-induced activation of TLR4 represents bacterial-induced interactions in various model systems. The present study examines how TLR2 and TLR4 expression is affected by symptomatic allergic rhinitis, and if LPS added upon allergen affects nasal cytokine release. Methods: In patients with pollen-induced allergic rhinitis and healthy non-allergic volunteers, nasal lavage (NAL), peripheral blood and bone marrow were sampled before and during the pollen season. TLR2 and TLR4 expression was determined flow cytometrically. Changes in the TLR receptor expression pattern were evaluated by a nasal challenge with allergen followed by LPS, or vice versa. Symptoms along with cells and cytokines in NAL were analyzed. Results: TLR4 expression increased in leukocytes in NAL, peripheral blood and bone marrow during symptomatic allergic rhinitis. A similar increase was seen for TLR2 in neutrophils in blood. Nasal challenge with allergen followed by LPS augmented the release of IL-4, IL-5, IL-10, IL-13, IFN-γ and TNF-α. Conclusion: A systemic up-regulation of TLR4 in symptomatic allergic rhinitis may explain why LPS preceded by allergen increases nasal cytokine release.

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A role for neutrophils in intermittent allergic rhinitis

Cited by 28 publications

References 25 publications

Individualized Treatment of Allergic Rhinitis According to Nasal Cytology

Individualized Treatment of Allergic Rhinitis According to Nasal Cytology

Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis

Systemic Up-Regulation of TLR4 Causes Lipopolysaccharide-Induced Augmentation of Nasal Cytokine Release in Allergic Rhinitis

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