A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat

Maric, Tia; Sedki, Firas; Chafetz, Danielle; Schoela, Nick; Shalev, Uri

doi:10.1007/s00213-011-2362-9

Cited by 12 publications

(4 citation statements)

References 51 publications

(58 reference statements)

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“…In line with these observations, Maric et al . () showed that food deprivation can induce reinstatement of heroin seeking and the NPY system can be involved in this effect as it was attenuated by Y 5 R blockade. These authors suggested that NPY is strongly involved at mediating reinforcing effects of heroin.…”

Section: Opioidsmentioning

confidence: 99%

Effects of drugs of abuse on the central neuropeptide Y system

et al. 2015

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Neuropeptide Y (NPY), which is widely expressed in the central nervous system is involved in several neuropathologies including addiction. Here we comprehensively and systematically review alterations on the central NPY system induced by several drugs. We report on the effects of psychostimulants [cocaine, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and nicotine], ethanol, and opioids on NPY protein levels and expression of different NPY receptors. Overall, expression and function of NPY and its receptors are changed under conditions of drug exposure, thus affecting several physiologic behaviors, such as feeding, stress and anxiety. Drugs of abuse differentially affect the components of the NPY system. For example methamphetamine and nicotine lead to a consistent increase in NPY mRNA and protein levels in different brain sites whereas ethanol and opioids decrease NPY mRNA and protein expression. Drug-induced alterations on the different NPY receptors show more complex regulation pattern. Manipulation of the NPY system can have opposing effects on reinforcing and addictive properties of drugs of abuse. NPY can produce pro-addictive effects (nicotine and heroin), but can also exert inhibitory effects on addictive behavior (AMPH, ethanol). Furthermore, NPY can act as a neuroprotective agent in chronically methamphetamine and MDMA-treated rodents. In conclusion, manipulation of the NPY system seems to be a potential target to counteract neural alterations, addiction-related behaviors and cognitive deficits induced by these drugs.

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Section: Opioidsmentioning

confidence: 99%

Effects of drugs of abuse on the central neuropeptide Y system

et al. 2015

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“…Given the importance of Pavlovian conditioning in the triggering of drug craving and relapse in detoxified addicts (Childress et al, 1988; O’Brien et al, 1992), the present results may have implications for management of abstinence. The possibility that food scarcity or physiological concomitants of underfeeding promote drug seeking was previously indicated by the finding that one day of total food deprivation triggered relapse to heroin seeking in rats (Shalev et al, 2001; Maric et al, 2011). However, the functional and physiological mechanisms underlying the effect of acute food deprivation and chronic food restriction are probably different.…”

Section: Discussionmentioning

confidence: 99%

Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats

Zheng

Vaca

2012

Pharmacology Biochemistry and Behavior

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Cocaine conditioned place preference (CPP) is more persistent in food-restricted than ad libitum fed rats. This study assessed whether food restriction acts during conditioning and/or expression to increase persistence. In Experiment 1, rats were food-restricted during conditioning with a 7.0 mg/kg (i.p.) dose of cocaine. After the first CPP test, half of the rats were switched to ad libitum feeding for three weeks, half remained on food restriction, and this was followed by CPP testing. Rats tested under the ad libitum feeding condition displayed extinction by the fifth test. Their CPP did not reinstate in response to overnight food deprivation or a cocaine prime. Rats maintained on food restriction displayed a persistent CPP. In Experiment 2, rats were ad libitum fed during conditioning with the 7.0 mg/kg dose. In the first test only a trend toward CPP was displayed. Rats maintained under the ad libitum feeding condition did not display a CPP during subsequent testing and did not respond to a cocaine prime. Rats tested under food-restriction also did not display a CPP, but expressed a CPP following a cocaine prime. In Experiment 3, rats were ad libitum fed during conditioning with a 12.0 mg/kg dose. After the first test, half of the rats were switched to food restriction for three weeks. Rats that were maintained under the ad libitum condition displayed extinction by the fourth test. Their CPP was not reinstated by a cocaine prime. Rats tested under food-restriction displayed a persistent CPP. These results indicate that food restriction lowers the threshold dose for cocaine CPP and interacts with a previously acquired CPP to increase its persistence. In so far as CPP models Pavlovian conditioning that contributes to addiction, these results suggest the importance of diet and the physiology of energy balance as modulatory factors.

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“…Circulating PACAP levels and a single nucleotide polymorphism in the PAC1 receptor gene have both been associated with PTSD and other stress-related disorders in women to further implicate PACAP/PAC1R function in stress- and anxiety-related states such as addiction ( Hashimoto et al, 2011 , 2016 ; Ressler et al, 2011 ). While these latter neuroactive peptides have produced some exciting, albeit very preliminary, results in the context of stress-induced reinstatement ( Maric et al, 2011 ; Miles et al, 2018 ; Schank et al, 2014 ; Schmoutz et al, 2012 ), none of these have been assessed in humans nor have their effects been examined in female animals. Thus, further discussion of these compounds has been excluded from the following sections.…”

Section: Neuroactive Peptide Targetsmentioning

confidence: 99%

Consideration of sex as a biological variable in the translation of pharmacotherapy for stress-associated drug seeking

Doncheck

Reichel

McRae‐Clark

2021

Neurobiology of Stress

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Stress is a frequent precipitant of relapse to drug use. Pharmacotherapies targeting a diverse array of neural systems have been assayed for efficacy in attenuating stress-induced drug-seeking in both rodents and in humans, but none have shown enough evidence of utility to warrant routine use in the clinic. We posit that a critical barrier in effective translation is inattention to sex as a biological variable at all phases of the research process. In this review, we detail the neurobiological systems implicated in stress-induced relapse to cocaine, opioids, methamphetamine, and cannabis, as well as the pharmacotherapies that have been used to target these systems in rodent models, the human laboratory, and in clinical trials. In each of these areas we additionally describe the potential influences of biological sex on outcomes, and how inattention to fundamental sex differences can lead to biases during drug development that contribute to the limited success of large clinical trials. Based on these observations, we determine that of the pharmacotherapies discussed only α 2 -adrenergic receptor agonists and oxytocin have a body of research with sufficient consideration of biological sex to warrant further clinical evaluation. Pharmacotherapies that target β-adrenergic receptors, other neuroactive peptides, the hypothalamic-pituitary-adrenal axis, neuroactive steroids, and the endogenous opioid and cannabinoid systems require further assessment in females at the preclinical and human laboratory levels before progression to clinical trials can be recommended.

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A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat

Abstract: These results suggest that while signals mediated through NPY Y1 receptors play a modest role in reinstatement, activation of Y5 receptors has a critical function in FD-induced reinstatement of heroin-seeking behavior.

Cited by 12 publications

References 51 publications

Effects of drugs of abuse on the central neuropeptide Y system

Effects of drugs of abuse on the central neuropeptide Y system

Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats

Consideration of sex as a biological variable in the translation of pharmacotherapy for stress-associated drug seeking

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