A role for left temporal pole in the retrieval of words for unique entities

Grabowski, Thomas J.; Damásio, Hanna; Tranel, Daniel; Ponto, Laura L. Boles; Hichwa, Richard D.; Damásio, António R.

doi:10.1002/hbm.1033

Cited by 284 publications

(128 citation statements)

References 72 publications

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“…Activation of this region has been found during decision tasks using sensory learned semantic knowledge [37,38]. Temporal pole would play the role of a multimodal associative cortex linking the posterior temporal-occipital-parietal cortices, presumably supporting conceptual processing, to the left perisylvian cortices, supporting phonological processing [37,39]. To our knowledge no activation of this region has previously been observed in simple calculation tasks.…”

Section: Brain Activationmentioning

confidence: 94%

“…Few previous functional imaging studies have evidenced activation of the left temporal pole in semantic memory task [37,38]. Activation of this region has been found during decision tasks using sensory learned semantic knowledge [37,38]. Temporal pole would play the role of a multimodal associative cortex linking the posterior temporal-occipital-parietal cortices, presumably supporting conceptual processing, to the left perisylvian cortices, supporting phonological processing [37,39].…”

Section: Brain Activationmentioning

confidence: 97%

“…Several neuropsychological studies show that anterior temporal lobe damage can cause deficits for items that are mainly defined by their sensory features such as concrete words (in this case the arithmetic facts) rather than abstract meaning (for a review, see [35,36]). Few previous functional imaging studies have evidenced activation of the left temporal pole in semantic memory task [37,38]. Activation of this region has been found during decision tasks using sensory learned semantic knowledge [37,38].…”

Section: Brain Activationmentioning

confidence: 98%

See 2 more Smart Citations

Functional MRI study of PASAT in normal subjects

Audoin

Ibarrola

Duong

et al. 2005

MAGMA

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The paced auditory serial addition test (PASAT) is routinely used to evaluate the cognitive part of the multiple sclerosis functional composite (MSFC) score, the new reference index of patient disability. PASAT is sensitive to subtle cognitive impairment related to MS, although the cognitive components of this test still remain unclear. In order to better characterize brain systems involved during this complex task, functional magnetic resonance imaging (fMRI) experiments were conducted during PASAT in a population of ten normal subjects. The paradigm consisted of a series of 61 single-digit numbers delivered every 3 s. After each number, subjects were asked to overt vocalize the result of the addition of the two last numbers heard. A control task consisting of the repetition of the same series of single-digit numbers was used. Statistical group analysis was performed using the random effect procedure (SPM 99). Cortical activation was observed in the left prefrontal cortex, the supplementary motor area, the lateral premotor cortex, the cingulate gyrus, the left parietal lobe, the left superior temporal gyrus, the left temporal pole, and visual associative areas. fMRI activations underlying PASAT were consistent with an involvement of verbal working memory and the semantic memory retrieval network which could be related to arithmetic fact retrieval. This study on normal subjects could provide a base for the understanding of the potential abnormal cortical activation in MS patients performing this test for a cognitive evaluation.

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Section: Brain Activationmentioning

confidence: 94%

Section: Brain Activationmentioning

confidence: 97%

Section: Brain Activationmentioning

confidence: 98%

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Functional MRI study of PASAT in normal subjects

Audoin

Ibarrola

Duong

et al. 2005

MAGMA

View full text Add to dashboard Cite

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“…The finding indicates that changes in the temporal pole vary between LOS and EOS. This area plays a crucial role in the retrieval of semantic and autobiographical memory [44,45] as well as in social cognition and emotional processing [46]. Previous studies have described reduced volumes of this region in schizophrenia [47,48,49], including first-episode patients [48,49] and those with chronic schizophrenia [47,50].…”

Section: Discussionmentioning

confidence: 99%

Different and Shared Brain Volume Abnormalities in Late- and Early-Onset Schizophrenia

Egashira

Matsuo²,

Mihara³

et al. 2014

Neuropsychobiology

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The differences in clinical characteristics between late- (LOS) and early-onset schizophrenia (EOS) are well documented. However, very little is known about the neural mechanisms underlying these differences. Here, we compared morphometric abnormalities between patients with EOS and those with LOS. A total of 22 patients with LOS, 24 patients with EOS and 41 healthy control subjects were included in this magnetic resonance imaging study. Brain images were analyzed using DARTEL preprocessing for voxel-based morphometry in SPM8. We tested a main effect of diagnosis in the whole-brain analysis and compared the results among the three groups. We also carried out correlation analyses between regional volumes and clinical variables. Patients with LOS showed larger gray matter (GM) volume of the left precuneus compared with healthy subjects and patients with EOS. Patients with LOS and EOS showed decreased GM volumes in the right insula, left superior temporal gyrus and left orbitofrontal gyrus compared with healthy subjects. A longer duration of illness was associated with reduced GM volume in the temporal pole in patients with EOS. Our findings may help improve our understanding of schizophrenia pathophysiology and shed light on the different and shared neurobiological underpinnings of LOS and EOS.

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“…This coordination is thought to be mediated by left extrasylvian cortical regions (con vergence zones) that are anatomically connected to both regions [6][7][8]. The association of the left temporal pole specifically with the production of proper names for per sons and places [4,[8][9][10] may also have to do with (1) the resolution of high visual ambiguity at the apex of the ventral visual stream [7], (2) the proximity of structures involved in social-affective processing [11], and/or (3) a role for the temporal pole as an amodal semantic hub [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Language treatment prior to anterior temporal lobe surgery: Can naming skills be preserved?

et al. 2016

Self Cite

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Abstract-Epilepsy affects 1% of the general population and is highly prevalent among Veterans. The purpose of this phase I study was to investigate a presurgical linguistically distrib uted language treatment program that could potentially dimin ish effects of proper-name retrieval deficits following left anterior temporal lobe resection for intractable epilepsy. A sin gle-subject multiple-baseline design was employed for three individuals with late-onset chronic left temporal lobe epilepsy. Word retrieval treatment was administered prior to anterior temporal lobe resection. The primary outcome measure was confrontation naming of proper nouns. Immediately posttreat ment (before surgery), there was a positive effect for all trained stimuli in the form of improved naming as compared with pre treatment. In addition, trained stimuli were found to be better after surgery than they were at pretreatment baseline, which would not be expected had language treatment not been pro vided. This series of case studies introduces two fundamentally novel concepts: that commonly occurring deficits associated with left temporal lobe epilepsy can be treated despite the pres ence of damaged neural tissue and that providing this treatment prior to surgery can lead to better preservation of language function after surgery than would be expected if the treatment were not provided.

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A role for left temporal pole in the retrieval of words for unique entities

Cited by 284 publications

References 72 publications

Functional MRI study of PASAT in normal subjects

Functional MRI study of PASAT in normal subjects

Different and Shared Brain Volume Abnormalities in Late- and Early-Onset Schizophrenia

Language treatment prior to anterior temporal lobe surgery: Can naming skills be preserved?

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