A Role for Interleukin-10 in the Assessment of Venous Thromboembolism Risk in Injured Patients

Proctor, Mary C.; Sullivan, Vita V.; Zajkowski, Paul J.; Wolk, Seth W.; Pomerantz, Richard A.; Wakefield, Thomas W.; Greenfield, Lazar J.

doi:10.1097/01.ta.0000197180.79965.bc

Cited by 12 publications

(7 citation statements)

References 7 publications

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“…The sP-selectin level difference was not statistically significant between the groups. Those patients who developed VTE had a higher sP/IL-10 ratio, where lower levels of IL-10 accounted for the ratio-difference, statistically significant to those without VTE ( 61 ).…”

Section: Adhesion Molecules and Vtementioning

confidence: 96%

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Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis

et al. 2018

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The inflammatory response is a well-established part of, and a prerequisite for, venous thrombosis. To better understand the pathophysiology of venous thrombosis and to identify improved diagnostic biomarkers, further studies of the relationship between inflammation and coagulation are needed. We review previous studies concerning inflammatory biomarkers in venous thromboembolism, in particular cytokines, soluble adhesion molecules and matrix metalloproteases as predisposing, diagnostic and prognostic factors in venous thrombosis. Elevated cytokines and genetic alterations coding for cytokines are found in several patient cohorts which indicate that cytokines are involved as predisposing factors in venous thrombosis development. Increased levels of pro-inflammatory cytokines are detected both in animal models and in patients with acute venous thrombosis and clinical trials, although currently without evident diagnostic value. Adhesion molecules are crucial in the development of venous thrombosis, especially P-selectin seems important in initiating leukocyte accumulation and adhesion to endothelium for subsequent platelet accumulation. Several studies have demonstrated increased soluble P-selectin levels in patients with venous thrombosis, emphasizing its potential role as diagnostic marker and also as a therapeutic target. Matrix metalloproteases are essential effectors during venous thrombosis resolution and may impact vessel wall fibrosis, and together with their natural occurring inhibitors are crucial in acute and chronic thrombosis pathophysiology. Furthermore, studies in animal models of venous thrombosis have demonstrated anti-inflammatory treatment to be effective in terms of thrombus resolution and reduction of vessel wall damage, without increase in bleeding risk during the course of treatment. Thus, soluble mediators should be further investigated both as possible biomarkers and therapeutic targets in venous thromboembolic disease.

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Section: Adhesion Molecules and Vtementioning

confidence: 96%

“…A number of small case-control studies demonstrated increased levels of pro-inflammatory, or decreased levels of anti-inflammatory, cytokines in patients at risk for DVT ( 61 , 63 , 45 ). Although in a larger, prospective population-based case-control study, no such associations were found ( 37 ).…”

Section: Cytokines and Vtementioning

confidence: 99%

Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis

et al. 2018

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“…A study by Proctor et al (19) indicated that IL-10 could be an important clinical predictor of thrombosis. IL-10 has also been found to exert anticoagulant properties (20).…”

Section: Discussionmentioning

confidence: 99%

Relationship between deep venous thrombosis and inflammatory cytokines in postoperative patients with malignant abdominal tumors

Tan

2014

Braz J Med Biol Res

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Deep venous thrombosis (DVT) is a common surgical complication in cancer patients and evidence that inflammation plays a role in the occurrence of DVT is increasing. We studied a population of cancer patients with abdominal malignancies with the aim of investigating whether the levels of circulating inflammatory cytokines were associated with postoperative DVT, and to determine the levels in DVT diagnoses. The serum levels of C-reactive protein (CRP), interleukins (IL)-6 and IL-10, nuclear transcription factor-κB (NF-κB) and E-selectin (E-Sel) were determined in 120 individuals, who were divided into 3 groups: healthy controls, patients with and patients without DVT after surgery for an abdominal malignancy. Data were analyzed by ANOVA, Dunnet's T3 test, chi-square test, and univariate and multivariate logistic regression as needed. The CRP, IL-6, NF-κB, and E-Sel levels in patients with DVT were significantly higher than those in the other groups (P<0.05). The IL-10 level was higher in patients with DVT than in controls but lower than in patients without DVT. Univariate analysis revealed that CRP, IL-6, NF-κB, and E-Sel were statistically associated with the risk of DVT (OR=1.98, P=0.002; OR=1.17, P=0.000; OR=1.03, P=0.042; and OR=1.38, P=0.003; respectively), whereas IL-10 had a protective effect (OR=0.94, P=0.011). Multivariate analysis showed that E-Sel was an independent risk factor (OR=1.41, P=0.000). Thus, this study indicated that an increased serum level of E-Sel was associated with increased DVT risk in postoperative patients with abdominal malignancy, indicating that E-Sel may be a useful predictor of diagnosis of DVT.

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“…An increased P-selectin/IL-10 ratio was found to be a risk factor for venous thrombosis in trauma patients (149), whereas selected haplotypes of selectins were not found to influence DVT risk in a large population-based study (173). Several studies have demonstrated increased P-selectin levels in VTE patients, both when compared to normal controls and as a diagnostic marker in symptomatic patients (154,171,172,(174)(175)(176)(177)(178)(179).…”

Section: Adhesion Molecules In Venous Thrombosismentioning

confidence: 99%

“…Inflammatory conditions are considered as a risk factor for venous thromboses (138)(139)(140)(141). However, some larger studies of altered inflammatory mediators indicated that both changes in inflammatory mediator levels -TNF- (149,150) and several SNPs of inflammatory mediators are associated with an IL-1 IL-IL-6, IL-10) (141,145).…”

Section: Inflammation-cause or Consequence?mentioning

confidence: 99%

Stem cell mobilization and harvesting by leukapheresis alters systemic cytokine levels in patients with multiple myeloma

et al. 2013

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A Role for Interleukin-10 in the Assessment of Venous Thromboembolism Risk in Injured Patients

Cited by 12 publications

References 7 publications

Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis

Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis

Relationship between deep venous thrombosis and inflammatory cytokines in postoperative patients with malignant abdominal tumors

Stem cell mobilization and harvesting by leukapheresis alters systemic cytokine levels in patients with multiple myeloma

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