A role for flavonoids in the prevention and/or treatment of cognitive dysfunction, learning, and memory deficits: a review of preclinical and clinical studies

Ramezani, Matin; Meymand, Arman Zeinaddini; Khodagholi, Fariba; Kamsorkh, Hamed Mohammadi; Asadi, Ehsan; Noori, Mitra; Rahimian, Kimia; Shahrbabaki, Ali Saberi; Talebi, Aisa; Parsaiyan, Hanieh; Shiravand, Sepideh; Darbandi, Niloufar

doi:10.1080/1028415x.2022.2028058

Cited by 14 publications

(9 citation statements)

References 90 publications

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“…However this is an emerging area and much more research is required to better understand the health promoting properties of flavonoids and polyphenolic substances delivered by the gut-lung and gut-brain axes, this may represent a new therapeutic frontier [451][452][453][454][455][456]. A number of recent studies have shown the potential of dietary flavonoids to treat neurodegenerative conditions [457,458], depression, anxiety and cognitive dysfunction [459][460][461][462] and Alzheimer's disease [463][464][465][466][467][468].…”

Section: Flavonoids the Gut Microbiome And The Gut-brain And Gut-lung...mentioning

confidence: 99%

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

Melrose¹,

Smith²

2022

Front. Biosci. (Elite Ed)

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The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue protective properties. Phytochemicals are widely distributed in plants, herbs and shrubs used in traditional complimentary medical formulations for centuries. The bioactive components that convey beneficial medicinal effects in these complex herbal preparations are now being identified using network pharmacology and molecular docking procedures that identify their molecular targets. Flavonoids have anti-oxidant, anti-inflammatory, antiviral, antibacterial and anti-cancer properties that have inspired the development of potent multifunctional derivatised flavonoids of improved efficacy. The antiviral properties of flavonoids and the emergence of the severe acute respiratory syndrome (SARS-CoV-2) pandemic has resulted in a resurgence of interest in phytochemicals in the search for efficacious compounds that can prevent viral infection or replication, with many promising plant compounds identified. Promising semi-synthetic flavonoid derivatives have also been developed that inhibit multiple pathological neurodegenerative processes; these offer considerable promise in the treatment of diseases of cognitive decline. Clinical trials are currently being undertaken to evaluate the efficacy of dietary supplements rich in flavonoids for the treatment of virally-mediated diseases. Such trials are expected to identify flavonoids with cell and tissue protective properties that can be harnessed in biomedical applications that may serve as supportive adjunctive procedures to conventional anti-viral drug therapies against diseases such as COVID-19.

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Section: Flavonoids the Gut Microbiome And The Gut-brain And Gut-lung...mentioning

confidence: 99%

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

Melrose¹,

Smith²

2022

Front. Biosci. (Elite Ed)

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“…Various in vitro as well as in vivo studies have been conducted defining the antioxidant and neuroprotective property of flavonoids. In addition multiple preclinical and clinical studies also reported the role of flavonoids in the prevention and treatment of cognitive dysfunction, learning, and memory deficits [ 8 ]. Acute or chronic administration of flavonoids crosses through the blood-brain barrier suggesting that these compounds can feasibly have a direct effect on the brain and hence could be used as a prophylactic agent [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…AD occures due to disturbance of multiple pathway, therefore, the multi-target approche thruogh hole plant extract will be more promising among the possible therapies. Ongoing analyses have demonstrated that consumption of flavonoid-rich diet can actually improve mental health and cognitive ability in people [5][6][7][8]. Furthermore, several flavonoids have been accounted to limit the progression of AD, and this has been originating from their capacity to improve cognitive function in various preclinical models [8].…”

Section: Introductionmentioning

confidence: 99%

“…Ongoing analyses have demonstrated that consumption of flavonoid-rich diet can actually improve mental health and cognitive ability in people [5][6][7][8]. Furthermore, several flavonoids have been accounted to limit the progression of AD, and this has been originating from their capacity to improve cognitive function in various preclinical models [8]. The flavonoid-rich foods like cocoa, citrus, green tea, and berry can be ascribed to the connections of flavonoids and their metabolites with various subcellular targets [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer’s Disease

Minocha

Birla

Obaid

et al. 2022

Oxidative Medicine and Cellular Longevity

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Alzheimer’s disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over the period of time. AD is characterized by cognitive dysfunctions, behavioural disability, and psychological impairments due to the accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles (NFT). Several research reports have shown that flavonoids are the polyphenolic compounds that significantly improve cognitive functions and inhibit or delay the amyloid beta aggregation or NFT formation in AD. Current research has uncovered that dietary use of flavonoid-rich food sources essentially increases intellectual abilities and postpones or hinders the senescence cycle and related neurodegenerative problems including AD. During AD pathogenesis, multiple signalling pathways are involved and to target a single pathway may relieve the symptoms but not provides the permanent cure. Flavonoids communicate with different signalling pathways and adjust their activities, accordingly prompting valuable neuroprotective impacts. Flavonoids likewise hamper the movement of obsessive indications of neurodegenerative disorders by hindering neuronal apoptosis incited by neurotoxic substances. In this short review, we briefly discussed about the classification of flavonoids and their neuroprotective properties that could be used as a potential source for the treatment of AD. In this review, we also highlight the structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production.

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“…Flavonoids also elevate synaptic activity and pro-survival neurogenesis markers [ 13 ]. Various flavonoids such as apigenin, hesperetin, naringin, quercetin and rutin also improve the cognitive performance of animals in the Morris water maze [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis

et al. 2022

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Alzheimer’s disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including Ananas comosus ‘Phulae’, Ananas comosus ‘Pattavia’, Carica papaya ‘Khaekdum’, Carica papaya ‘Khaeknuan’, Durio zibethinus ‘Monthong’, Durio zibethinus ‘Chanee’, Psidium guajava ‘Kimju’, Psidium guajava ‘Keenok’, Mangifera indica ‘Kaew’ and Mangifera indica ‘Namdokmai’ were screened for their inhibitory activities against the key enzymes, cholinesterases and β-secretase (BACE-1), involved in AD pathogenesis. The top three fruit extracts with promising in vitro anti-AD activities were further investigated using rat pheochromocytoma PC-12 neuronal cell line and Drosophila AD model. Data showed that M. indica ‘Kaew’, M. indica ‘Namdokmai’ and P. guajava ‘Kimju’ reduced Aβ1–42-mediated neurotoxicity by promoting glutathione-dependent enzymes, while M. indica ‘Namdokmai’ limited Aβ1–42 peptide formation via BACE-1 inhibition and amended locomotory behavior of the Drosophila AD model. Results indicated the potential anti-AD properties of tropical fruits, particularly M. indica ‘Namdokmai’ in the prevention of Aβ1–42-mediated neurotoxicity and as a BACE-1 blocker.

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A role for flavonoids in the prevention and/or treatment of cognitive dysfunction, learning, and memory deficits: a review of preclinical and clinical studies

Cited by 14 publications

References 90 publications

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer’s Disease

Mangifera indica ‘Namdokmai’ Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer’s Amyloidosis

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