A role for ELAM-1 in the pathogenesis of MOF during septic shock

Engelberts, I.; Samyo, Steven K.; Leeuwenberg, J. F. M.; Linden, C. J. Van Der; Buurman, Wim A.

doi:10.1016/0022-4804(92)90025-u

Cited by 52 publications

(16 citation statements)

References 22 publications

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“…IL-8 levels are increased in sputum from COPD patients compared with those in sputum of control subjects (nonsmokers, cigarette smokers without disease, or asthmatic patients) (78). A similar increase in the expression of intercellular adhesion molecule 1 (ICAM-1) has been observed in asthma, chronic bronchitis, ARDS, and COPD (79,80). ICAM-1 promotes immunologic and inflammatory reactions such as leukocyte diapedesis within the lung.…”

Section: Role Of Ros/rns In Inflammatory Respiratory Disease Expressimentioning

confidence: 74%

The role of reactive oxygen and nitrogen species in airway epithelial gene expression.

Martin

Krunkosky

Voynow

et al. 1998

Environ Health Perspect

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The body first encounters deleterious inhaled substances, such as allergens, industrial particles, pollutants, and infectious agents, at the airway epithelium. When this occurs, the epithelium and its resident inflammatory cells respond defensively by increasing production of cytokines, mucus, and reactive oxygen and nitrogen species (ROS/RNS). As inflammation in the airway increases, additional infiltrating cells increase the level of these products. Recent interest has focused on ROS/RNS as potential modulators of the expression of inflammation-associated genes important to the pathogenesis of various respiratory diseases. ROS/RNS appear to play a variety of roles that lead to changes in expression of genes such as interleukin-6 and intercellular adhesion molecule 1. By controlling this regulation, the reactive species can serve as exogenous stimuli, as intercellular signaling molecules, and as modulators of the redox state in epithelial cells. Unraveling the molecular mechanisms affected by ROS/RNS acting in these capacities should aid in the understanding of how stimulated defense mechanisms within the airway can lead to disease.

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Section: Role Of Ros/rns In Inflammatory Respiratory Disease Expressimentioning

confidence: 74%

The role of reactive oxygen and nitrogen species in airway epithelial gene expression.

Martin

Krunkosky

Voynow

et al. 1998

Environ Health Perspect

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“…LQGV treatment was also associated with a significant reduction of neutrophil accumulation in the liver [23]. Endothelial activation, characterized by increased expression of adhesion molecules [E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)] and subsequent tissue infiltration by neutrophils is an early event in septic shock and a crucial step towards the development of organ failure [20,25,26]. E-selectin blockage has been shown to protect against neutrophil-induced tissue injury during endotoxaemia in mice [27].…”

Section: Discussionmentioning

confidence: 99%

Mitigation of septic shock in mice and rhesus monkeys by human chorionic gonadotrophin-related oligopeptides

Khan

Vierboom²,

Holten-Neelen

et al. 2010

Clinical and Experimental Immunology

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SummaryThe marked improvement of several immune-mediated inflammatory diseases during pregnancy has drawn attention to pregnancy hormones as potential therapeutics for such disorders. Low molecular weight fractions derived from the pregnancy hormone human chorionic gonadotrophin (hCG) have remarkable potent immunosuppressive effects in mouse models of diabetes and septic shock. Based on these data we have designed a set of oligopeptides related to the primary structure of hCG and tested these in models of septic shock in mice and rhesus monkeys. We demonstrate that mice exposed to lipopolysaccharide (LPS) and treated subsequently with selected tri-, tetra-, penta-and hepta-meric oligopeptides (i.e. MTR, VVC, MTRV, LQGV, AQGV, VLPALP, VLPALPQ) are protected against fatal LPS-induced septic shock. Moreover, administration of a cocktail of three selected oligopeptides (LQGV, AQGV and VLPALP) improved the pathological features markedly and nearly improved haemodynamic parameters associated with intravenous Escherichia coli-induced septic shock in rhesus monkeys. These data indicate that the designed hCG-related oligopeptides may present a potential treatment for the initial hyperdynamic phase of septic shock in humans.

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“…5,6 Consequently, E-selectin expression, which is absent in control livers, can be up-regulated under inflammatory conditions in experimental animals [7][8][9][10] and humans. [11][12][13] Although there appear to be some variations in E-selectin expression depending on the disease state, the general consensus from these studies is that E-selectin is most strongly expressed on endothelial cells of portal tract vessels and hepatic venules and to a lesser degree on sinusoidal lining cells.…”

mentioning

confidence: 99%

Pathophysiologic Importance of E- and L-Selectin for Neutrophil-Induced Liver Injury During Endotoxemia in Mice

et al. 2000

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A role for ELAM-1 in the pathogenesis of MOF during septic shock

Cited by 52 publications

References 22 publications

The role of reactive oxygen and nitrogen species in airway epithelial gene expression.

The role of reactive oxygen and nitrogen species in airway epithelial gene expression.

Mitigation of septic shock in mice and rhesus monkeys by human chorionic gonadotrophin-related oligopeptides

Pathophysiologic Importance of E- and L-Selectin for Neutrophil-Induced Liver Injury During Endotoxemia in Mice

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