A role for corticotropin-releasing factor, but not corticosterone, in acute food-deprivation-induced reinstatement of heroin seeking in rats

Shalev, Uri; Finnie, P; Quinn, Tammie; Tobin, Stephanie; Wahi, Priti

doi:10.1007/s00213-006-0427-y

Cited by 59 publications

(46 citation statements)

References 56 publications

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“…This is consistent with reports that acute stress-induced increases in corticosterone are not necessary for reinstatement following cocaine or heroin SA (Shaham et Erb et al, 1998;Shalev et al, 2006). These findings parallel clinical reports that although drug-, cue-and stress-induced drug craving are accompanied by activation of the HPA axis (Berger et al, 1996;Ward et al, 1999;Sinha et al, 2003), pharmacological inhibition of glucocorticoid secretion has little or no effect on evoked craving in cocaine-dependent individuals (Harris et al, 2004;Winhusen et al, 2005).…”

Section: Role Of Glucocorticoids In Stress-and Crf-induced Reinstatementsupporting

confidence: 90%

Adrenal Activity during Repeated Long-Access Cocaine Self-Administration is Required for Later CRF-Induced and CRF-Dependent Stressor-Induced Reinstatement in Rats

Graf

Hoks

Baumgardner

et al. 2011

Neuropsychopharmacol

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Section: Role Of Glucocorticoids In Stress-and Crf-induced Reinstatementsupporting

confidence: 90%

Adrenal Activity during Repeated Long-Access Cocaine Self-Administration is Required for Later CRF-Induced and CRF-Dependent Stressor-Induced Reinstatement in Rats

Graf

Hoks

Baumgardner

et al. 2011

Neuropsychopharmacol

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“…It is well established that the activation of central CRF system is essential for stress-induced reinstatement of drug-seeking behavior (Shaham et al, 1997;Le et al, 2000;Shalev et al, 2006), and CRF receptor antagonism blocks this stress effect (Shaham et al, 1998). Identifying the BNST as a key structure for mediating this phenomenon, Erb and Stewart reported that stress-induced reinstatement of drugseeking behavior is mimicked by an intra-BNST injection of CRF and blocked by an intra-BNST injection of a CRF antagonist, D-Phe CRF (Erb and Stewart, 1999).…”

Section: Discussionmentioning

confidence: 99%

Repeated Stimulation of CRF Receptors in the BNST of Rats Selectively Induces Social but not Panic-Like Anxiety

Lee

Fitz

Johnson

et al. 2008

Neuropsychopharmacol

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Increased extra-hypothalamic corticotrophin-releasing factor (CRF) neurotransmission has been suggested as one putative factor in the pathophysiology of anxiety disorders. We have previously reported that administering repeated subanxiogenic doses (termed 'priming') of the CRF receptor agonist urocortin 1 (Ucn1) into the basolateral amygdala (BLA) of rats elicited long-lasting behavioral changes in social interaction (SI) and elevated plus maze (EPM) tests of anxiety. Although substantial similarity exists, the bed nucleus of the stria terminals (BNST) and the amygdala are thought to play distinct roles in anxiety responses. Rats primed with Ucn1 in the BLA not only demonstrated increased anxiety-like behaviors, but also physiological sensitivity to intravenous sodium lactate infusions, which is seen in subjects with panic or posttraumatic stress disorders, but not social or generalized anxiety disorders. In the present study, we tested if similar priming with subanxiogenic doses of Ucn1 in the BNST of rats will induce either chronic anxiety or sensitivity to sodium lactate. After determining the dose of Ucn1 that is subanxiogenic when injected into the BNST, repeated intra-BNST injections of this subanxiogenic dose of Ucn1 (6 fmol/100 nl) elicited persistent (present even after 4 weeks) anxiety-like responses in the SI but not EPM test. Prior local injection of a CRF receptor antagonist, astressin, into the BNST blocked this effect. Unlike Ucn1 priming in the BLA, rats primed in the BNST showed no cardiovascular changes following lactate infusion. Thus, BNST priming appears to selectively model the pathophysiology of subjects with anxiety syndromes like social anxiety, which are not lactate sensitive.

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“…As animal models have clearly demonstrated, CRFR1 antagonists are effective in attenuating stress-induced relapse to drug taking (76,(82)(83)(84). CP-154,526, a CRFR1 nonpeptide antagonist, attenuates stress-induced relapse to drug seeking in rats (77).…”

Section: Therapiesmentioning

confidence: 99%

Making a bad thing worse: adverse effects of stress on drug addiction

Cleck¹,

Blendy²

2008

J. Clin. Invest.

105

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Sustained exposure to various psychological stressors can exacerbate neuropsychiatric disorders, including drug addiction. Addiction is a chronic brain disease in which individuals cannot control their need for drugs, despite negative health and social consequences. The brains of addicted individuals are altered and respond very differently to stress than those of individuals who are not addicted. In this Review, we highlight some of the common effects of stress and drugs of abuse throughout the addiction cycle. We also discuss both animal and human studies that suggest treating the stress-related aspects of drug addiction is likely to be an important contributing factor to a long-lasting recovery from this disorder.

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A role for corticotropin-releasing factor, but not corticosterone, in acute food-deprivation-induced reinstatement of heroin seeking in rats

Abstract: The present data suggest that, as demonstrated for footshock-induced reinstatement of drug seeking, brain CRF, but not corticosterone, plays a critical role in acute food-deprivation-induced reinstatement of heroin seeking.

Cited by 59 publications

References 56 publications

Adrenal Activity during Repeated Long-Access Cocaine Self-Administration is Required for Later CRF-Induced and CRF-Dependent Stressor-Induced Reinstatement in Rats

Adrenal Activity during Repeated Long-Access Cocaine Self-Administration is Required for Later CRF-Induced and CRF-Dependent Stressor-Induced Reinstatement in Rats

Repeated Stimulation of CRF Receptors in the BNST of Rats Selectively Induces Social but not Panic-Like Anxiety

Making a bad thing worse: adverse effects of stress on drug addiction

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