A role for class I PAKs in the regulation of the excitability of the actin cytoskeleton
Joe J. Tyler,
Anthony Davidson,
Megan E. Poxon
et al.
Abstract:P21 activated kinases (PAKs) are involved in a wide range of functions from the regulation of the cytoskeleton to the control of apoptosis and proliferation. Although many PAK substrates identified are implicated in the regulation of the actin cytoskeleton, a coherent picture of the total effect of PAK activation on the state of the actin cytoskeleton is unclear. We therefore set out to observe and quantify the effect of PAK inhibition on the actin cytoskeleton in greater detail. In Mouse Embryonic Fibroblasts… Show more
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