A role for CD95 ligand in preventing graft rejection

Expression of Fas ligand by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancer

“…We have previously shown that FasL expressed by colon adenocarcinoma cells in vitro is biologically active: SW620 cells induced Fas mediated apoptosis of co-cultured Jurkat T cells. As an established mediator of immune privilege and immunological tolerance in the eye8 and testis,9 our finding that gastric tumours express FasL suggests that FasL contributes to the immune evasion of stomach cancer.…”

“…FasL is involved in mediating immune privilege in the eye,8 testis,9 and placenta,24 in contributing to immunological tolerance in the periphery,5 in downsizing immune responses,6 7 and in supporting experimental allograft survival in most cases 10-13. All of these roles involve FasL mediated apoptosis of lymphocytes.…”

“…FasL mediated apoptosis contributes to the regulation of the immune system through its roles in tolerance acquisition,5 T cell activation induced cell death,6 and immune response termination 78 and the testis9 mediates immune privilege by inducing apoptosis in infiltrating proinflammatory immunocytes. FasL has been shown to confer immunological privilege in tissue transplantation experiments.…”

“…FasL has been shown to confer immunological privilege in tissue transplantation experiments. In rodents, successful allograft survival was obtained of FasL expressing tissues9 10 and of non-immune privileged cells (pancreatic islets) co-transplanted with FasL expressing cells 1112 Allograft transplantation of murine tumour cells stably transfected with the FasL gene showed that FasL can cause local suppression of both humoral and cellular allograft specific immune responses 13…”

Corneal transplantation: how successful are we?

“…The topical application of interleukin 1a receptor antibody could potentially prevent the migration of Langerhans cells from the host into the donor tissue, thereby reducing the recognition by T cells through the indirect pathway 33. Other studies have outlined the importance of the expression of cell surface inhibitors of immune effectors such as the Fas and Fas ligand 34. These molecules are implicated in the process of immune tolerance by causing T cell apoptosis 35.…”