A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice

Shafaroodi, Hamed; Barati, Saghar; Ghasemi, Mehdi; Almasirad, Ali; Moezi, Leila

doi:10.1016/j.eplepsyres.2016.01.003

Cited by 15 publications

(6 citation statements)

References 45 publications

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“…Moreover, a number of drugs that display anticonvulsant properties in animal models may exert their effects through K ATP channels. Examples include the inotropic calcium sensitizers levosimendan (183), glycolytic inhibitor 2-deoxy-D-glucose (594), K + -sparing diuretic riamterene (594), hypnotic agent zolpidem (469) and fatty acid caprylic acid (472) though the mechanisms are complex and mostly seem to be indirect in nature. Another interesting example is the anticonvulsant and analgesic gabapentin which decreases [3H]noradrenaline release from rat hippocampal and human neocortical slices.…”

Section: Miscellaneous Agentsmentioning

confidence: 99%

ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles

Tinker

Aziz

et al. 2018

Comprehensive Physiology

111

112

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ATP sensitive potassium channels (K ) are so named because they open as cellular ATP levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to membrane excitability. They also respond to MgADP and are regulated by a number of cell signaling pathways. They have a rich and diverse pharmacology with a number of agents acting as specific inhibitors and activators. K channels are formed of pore-forming subunits, Kir6.1 and Kir6.2, and a large auxiliary subunit, the sulfonylurea receptor (SUR1, SUR2A, and SUR2B). The Kir6.0 subunits are a member of the inwardly rectifying family of potassium channels and the sulfonylurea receptor is part of the ATP-binding cassette family of proteins. Four SURs and four Kir6.x form an octameric channel complex and the association of a particular SUR with a specific Kir6.x subunit constitutes the K current in a particular tissue. A combination of mutagenesis work combined with structural studies has identified how these channels work as molecular machines. They have a variety of physiological roles including controlling the release of insulin from pancreatic β cells and regulating blood vessel tone and blood pressure. Furthermore, mutations in the genes underlie human diseases such as congenital diabetes and hyperinsulinism. Additionally, opening of these channels is protective in a number of pathological conditions such as myocardial ischemia and stroke. © 2018 American Physiological Society. Compr Physiol 8:1463-1511, 2018.

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Section: Miscellaneous Agentsmentioning

confidence: 99%

ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles

Tinker

Aziz

et al. 2018

Comprehensive Physiology

111

112

View full text Add to dashboard Cite

show abstract

“…Research has shown that it plays a dual role in attenuating cerebral edema and improving long-term cognitive function in pilocarpine-induced mouse model of status epilepticus [156]. Acute administration of glyburide, 30 min prior to the PTZ, significantly increased the seizure threshold in intravenous PTZ mode of mice [157].…”

Section: Nlrp3 Inhibitors In Preclinical and Clinical Trial Phasementioning

confidence: 99%

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Haque,

Thapa,

Burns

et al. 2024

Preprint

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Epilepsy is one of the most prevalent and serious brain disorders, affecting 70 million people worldwide. Antiseizure medications (ASMs) though relieve symptoms and prevent the occurrence of future seizures in epileptic patients have limited effect on epileptogenesis. Addressing the multifaceted nature of epileptogenesis and its association with Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated neuroinflammation requires a comprehensive understanding of the underlying mechanisms for development of targeted therapeutic strategies beyond conventional antiseizure treatments. Several types of NLRP3 inhibitors have been developed and their effect has been validated both in vitro and in vivo models of epileptogenesis. In this review, we discuss the advances in understanding the regulatory mechanisms of NLRP3 activation as well as progress made and challenges facing in the development of NLRP3 inhibitors for the treatment of epilepsy.

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“…Research has shown that it plays a dual role in attenuating cerebral edema and improving long-term cognitive function in a pilocarpine-induced mouse model of status epilepticus [ 154 ]. Acute administration of glyburide, 30 min prior to the PTZ, significantly increased the seizure threshold in an intravenous PTZ model of mice [ 155 ].…”

Section: Nlrp3 Inflammasome In Epilepsymentioning

confidence: 99%

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Haque,

Thapa,

Burns

et al. 2024

IJMS

View full text Add to dashboard Cite

Epilepsy is one of the most prevalent and serious brain disorders and affects over 70 million people globally. Antiseizure medications (ASMs) relieve symptoms and prevent the occurrence of future seizures in epileptic patients but have a limited effect on epileptogenesis. Addressing the multifaceted nature of epileptogenesis and its association with the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated neuroinflammation requires a comprehensive understanding of the underlying mechanisms of these medications for the development of targeted therapeutic strategies beyond conventional antiseizure treatments. Several types of NLRP3 inhibitors have been developed and their effect has been validated both in in vitro and in vivo models of epileptogenesis. In this review, we discuss the advances in understanding the regulatory mechanisms of NLRP3 activation as well as progress made, and challenges faced in the development of NLRP3 inhibitors for the treatment of epilepsy.

show abstract

A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice

Cited by 15 publications

References 45 publications

ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles

ATP‐Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

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