Abstract:IntroductionAs a result of the high sequence similarity between 60-kDa heat shock proteins (HSP60), found in both prokaryotic and eukaryotic cells, it has been suggested, but never concluded, that anti-HSP60 antibodies could be of importance in the pathology of arthritis diseases explained by a concept named molecular mimicry. In a number of clinical studies, antibodies to both human and bacterial HSP60 have been detected in serum from patients with different inflammatory diseases, but divergent results have b… Show more
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