A role for adrenoceptors in the regulation of pleural neutrophilia induced by LPS

Altenburg, Sonia P.; Silva, Sérvio Paixão e; Ventura, Diana G; Gomes, Rachel Novaes; Bozza, Patrı́cia T.; Castro‐Faria‐Neto, Hugo C.

doi:10.1016/s0165-5728(00)00376-3

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…The β 2 ‐adrenergic receptor subtype mediates several of the observed effects of catecholamines on neutrophils (Benschop et al ., 1996), such as generation of reactive oxygen intermediates in granulocytes in response to activation with formyl‐Met‐Leu‐Phe (fMLP) (Opdahl et al ., 1993) and interleukin (IL)‐8 production in macrophages (Kavelaars et al ., 1997). Of relevance to our findings, epinephrine acts via β 1 ‐adrenergic receptors to increase neutrophil migration (Jain et al ., 2003) and antagonizing α 2 ‐adrenergic receptors inhibits LPS‐induced neutrophil recruitment into pleura (Altenburg et al ., 2000). Since nonhabituating sound stress produces a chronic increase in plasma epinephrine (P.G.…”

Section: Discussionmentioning

confidence: 99%

Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat

Barker

Dazin

Levine

et al. 2005

British J Pharmacology

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1 Since stress both activates the sympathoadrenal axis and profoundly affects inflammation and inflammatory diseases, many of which are sexually dimorphic, we tested whether the effect of stress on neutrophil recruitment, a primary component of the acute inflammatory response, is sexually dimorphic. 2 The effect of intermittent sound (over 4 days), a nonhabituating stress, on lipopolysaccharide (LPS)-induced recruitment of neutrophils was evaluated in vivo in the rat air pouch model. At 24 h following the last stress exposure, LPS-induced neutrophil recruitment was enhanced in male rats, but not in females.3 When gonadectomized prepubertally and tested as adults, stress significantly inhibited the magnitude of LPS-induced neutrophil recruitment in males, while it still had no effect in gonadectomized females. In males, following adrenal denervation, the increase in LPS-induced neutrophil recruitment produced by stress was prevented. Since these data suggest that the effect of stress is dependent on the sympathoadrenal axis, we tested the hypothesis that catecholamines mediate the stress effects. 4 In male rats, the effect of stress on LPS-induced neutrophil recruitment was significantly attenuated by continuous administration of the b-adrenergic receptor antagonist, propranolol (4 mg kg À1 day À1), during sound stress exposure, and administration of isoproterenol (10 nmoles, i.v.) significantly increased neutrophil recruitment in males, an effect that was qualitatively and quantitatively similar to the effect of stress. Propranolol significantly increased neutrophil recruitment in nonstressed female rats, but did not significantly affect neutrophil recruitment in stressed females. 5 These findings indicate a marked male sex hormone-dependent sexual dimorphism in the sympathoadrenal-dependent effect of stress on neutrophil migration, a primary component of the inflammatory response, and suggest that the sympathoadrenal axis contributes to this effect via release of epinephrine.

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Section: Discussionmentioning

confidence: 99%

Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat

Barker

Dazin

Levine

et al. 2005

British J Pharmacology

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“…This implies that in in vivo studies the influence of catecholamines on neutrophil functions such as trafficking and activation needs to be taken into account (Abraham et al. , 1999; Altenburg et al. , 2000).…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that stress and intensity of exercise influenced the oxidative metabolism of human and equine neutrophils (Pyne et al, 2000;Art et al, 2006). This implies that in in vivo studies the influence of catecholamines on neutrophil functions such as trafficking and activation needs to be taken into account (Abraham et al, 1999;Altenburg et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

In vivoadministration of acepromazine or promethazine to horse decreases the reactive oxygen species production response of subsequently isolated neutrophils to stimulation with phorbol myristate acetate

Peters

Franck

Pequito

et al. 2009

Vet Pharm & Therapeutics

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The previous experiments have shown that some phenothiazines have antioxidant and anti-inflammatory properties in vitro. In this study the inhibition of the production of reactive oxygen species (ROS) by neutrophils was studied in two groups of horses, which received a dose of 0.1 mg/kg of either acepromazine or promethazine intravenously. Blood samples were collected before (T0) and 0.5, 1, 3 and 5 h after drug administration. The chemiluminescence (CML) response of neutrophils was measured ex vivo in the presence of luminol for a period of 10 min and the maximum CML value (peak value) recorded. There was a significant inhibition of the ROS production in the acepromazine treated group (49% inhibition) at 5 h after administration and in the promethazine group (24% inhibition) at 3 h after administration (P < 0.05 vs. T0). These findings are of therapeutic relevance in the use of phenothiazines in equine patients with inflammatory diseases where neutrophil activation and ROS production are implicated.

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“…Suas funções em relação às alterações no sistema imunológico e na inflamação não estão bem definidas, e se encontram na literatura informações conflitantes (NISHINA et al, 1999;ALTENBURG et al, 2000;TANIGUCHI et al, 2004;INADA et al, 2005).…”

Section: Dexmedetomidinaunclassified

“…As catecolaminas exercem um papel importante na migração tecidual de neutrófilos e sua depleção pode alterar significativamente esta função (ALTENBURG et al, 2000).…”

Section: Choque Sépticounclassified

Uso da dexmedetomidina no choque séptico: estudo experimental dos efeitos hemodinâmicos, metabólicos e inflamatórios

Carnicelli¹

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A role for adrenoceptors in the regulation of pleural neutrophilia induced by LPS

Cited by 9 publications

References 24 publications

Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat

Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat

In vivoadministration of acepromazine or promethazine to horse decreases the reactive oxygen species production response of subsequently isolated neutrophils to stimulation with phorbol myristate acetate

Uso da dexmedetomidina no choque séptico: estudo experimental dos efeitos hemodinâmicos, metabólicos e inflamatórios

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