A role for 5‐hydroxytryptamine in the GABA‐mimetic potentiation of α‐flupenthixol‐induced catalepsy in the rat

Davies, John A.; Williams, John G.

doi:10.1111/j.1476-5381.1983.tb09373.x

Cited by 18 publications

(1 citation statement)

References 27 publications

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“…This apparent discrepancy also may be attributable to a difference in the AP concentrations achieved by direct administration of AP and by treatment with clozapine. Moreover, the antagonistic properties of clozapine at serotonin receptors may also be relevant in this regard, given that depletion of endogenous serotonin or coadministration of serotonin antagonists abolishes the potentiation of neuroleptic-induced catalepsy elicited by an increase in the concentration of endogenous GABA or co-administration of a benzodiazepine drug (Davies and Williams 1983).…”

Section: Discussionmentioning

confidence: 99%

Clozapine, but not Haloperidol, Increases Brain Concentrations of Neuroactive Steroids in the Rat

Barbaccia

Affricano

Purdy

et al. 2001

Neuropsychopharmacology

104

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The extrapyramidal side effects of typical antipsychotics, which are induced to a markedly reduced extent by clozapine, have been linked to a dysfunction of central ␥ -aminobutyric acid (GABA)-mediated neurotransmission. The effects of clozapine on the brain concentrations of 3 ␣ -hydroxy-5 ␣ AP) and 3 ␣ , THDOC)Clozapine, the prototype of atypical antipsychotic drugs, exhibits the clinical efficacy of classical antipsychotics but lacks or induces to a greatly reduced extent most of the motor side effects of these latter drugs. The molecular mechanisms that underlie the pharmacological profile of clozapine remain unclear. Emphasis has been placed on the purported "selective" action of clozapine on mesocortical and mesolimbic dopaminergic pathways thought to result from its higher affinity for D 4 dopamine receptors than for D 2 receptors (Seeman 1992), as well as on its mixed antagonistic/agonistic action at D 2 and D 1 receptors (Coward et al. 1989;Brunello et al., 1995;Gerlach et al. 1996) and its high affinity for different subtypes of serotonin receptors (Brunello et al. 1995). More recently, the ratios of the affinities of clozapine for D 2 and 5HT 1a , D 2 and 5HT 1b or 5HT 1d , and D 2 and ␣ 2 -adrenergic receptors have been suggested to play a role in the anticata-

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Section: Discussionmentioning

confidence: 99%