A Robust Temperature Controller Design for an Innovative Hyperthermic Intraperitoneal Chemotherapy Equipment

Abstract

This paper presents an advanced control structure for controlling the heating process of cytostatic solution used in regional chemotherapy. The solution temperature control is an individual control structure which is desired to be implemented on hyperthermic intraperitioneal chemotherapy (HIPEC) innovative device. Cytoreductive surgery followed by HIPEC represents a therapeutic solution for patients suffering from peritoneal carcinomatosis, an abdominal cancer. An H∞ robust control structure is designed since the heating process model's parameters depend on the solution's delivery flow. It is considered that the heating process gain can vary from a nominal value to a maximum value, which represents an increase by up to 100% from the nominal value. The responses to a step input signal for the nominal case, and the cases when the gain varies by 50% or 100%, are simulated. The control structure is compared against a PID feasible controller by means of overall performances. It resulted that the robust controller generates the best performance set for the nominal gain and also for the case when the heating process gain varies.

Comparative Sensing and Judgment Control System for Temperature Maintenance for Optimal Treatment in Hyperthermic Intraperitoneal Chemotherapy Surgery

“…Since the intraperitoneal temperature must be maintained between 41 and 43 °C, precise control technology within ±5% is required by rapidly detecting a decrease or increase in heat. Accordingly, steady temperature control through instantaneous resistance heating is a desirable solution that provides a control accuracy within ±0.5% [ 36 ].…”

“…When the drug flows into the catheter after the desired temperature is achieved, the temperature in the abdominal cavity is monitored at 40.5-41.5 • C with a set temperature of 45.3 • C. Since the intraperitoneal temperature must be maintained between 41 and 43 • C, precise control technology within ±5% is required by rapidly detecting a decrease or increase in heat. Accordingly, steady temperature control through instantaneous resistance heating is a desirable solution that provides a control accuracy within ±0.5% [36].…”