A Robust, One‐Pot Synthesis of Highly Mechanical and Recoverable Double Network Hydrogels Using Thermoreversible Sol‐Gel Polysaccharide

Chen, Qiang; Zhu, Lin; Zhao, Chao; Wang, Qiuming; Zheng, Jie

doi:10.1002/adma.201300817

Cited by 624 publications

(596 citation statements)

References 31 publications

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“…A relatively recent innovation is the advent of ioniccovalent entanglement (ICE) network hydrogels which can be prepared in a "one-pot" synthetic approach 14,16,[18][19][20] . ICE hydrogels consist of a tough and self-recovering, interpenetrating network of an ionotropic polymer and a chemically cross-linkable polymer and have demonstrated some impressive mechanical properties 10,21,22 .…”

Section: Introductionmentioning

confidence: 99%

Robust biopolymer based ionic–covalent entanglement hydrogels with reversible mechanical behaviour

Kirchmajer

Panhuis

2014

J. Mater. Chem. B

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Robust biopolymer based ionic-covalent entanglement hydrogels with reversible mechanical behaviour AbstractEmerging applications of hydrogels such as soft robotics and cartilage tissue scaffolds require hydrogels with enhanced mechanical performance. We report the development of a robust biopolymer based ionic-covalent entanglement network hydrogel made from calcium cross-linked gellan gum and genipin cross-linked gelatin. The ratio of the two polymers and the cross-linker concentrations significantly affected the mechanical characteristics of the hydrogels. Hydrogels with optimized composition exhibited compressive fracture stress and work of extension values of up to 1.1 ± 0.2 MPa and 230 ± 40 kJ m−3 for swelling ratios of 37.4 ± 0.6 and 19 ± 1, respectively. The compressive and tensile mechanical properties, swelling behavior (including leachage), pH sensitivity and homogeneity are discussed in detail. Fully swollen hydrogels (swelling ratio of 37.4 ± 0.6) were able to recover 95 ± 2% and 82 ± 7% of their energy dissipation (hysteresis) at 37 °C after reloading to either constant stress (150 kPa) or constant strain (50%), respectively. Emerging applications of hydrogels such as soft robotics and cartilage tissue scaffolds require hydrogels with enhanced mechanical performance. We report the development of a robust biopolymer based ionic-covalent entanglement network hydrogel made from calcium cross-linked gellan gum and genipin cross-linked gelatin. The ratio of the two polymers and the cross-linker concentrations significantly affected the mechanical characteristics of the hydrogels. Hydrogels with optimized composition exhibited compressive fracture stress and work of extension values of up to 1.1 ± 0.2 MPa and 230 ± 40 kJ.m -3 for swelling ratios of 37.4 ± 0.6 and 19 ± 1, respectively. The compressive and tensile mechanical properties, swelling behavior (including leachage), pH sensitivity and homogeneity are discussed in detail. Fully swollen hydrogels (swelling ratio of 37.4 ± 0.6) were able to recover 95 ± 2% and 82 ± 7% of their energy dissipation (hysteresis) at 37 °C after reloading to either constant stress (150 kPa) or constant strain (50%), respectively.

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Section: Introductionmentioning

confidence: 99%

Robust biopolymer based ionic–covalent entanglement hydrogels with reversible mechanical behaviour

Kirchmajer

Panhuis

2014

J. Mater. Chem. B

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“…Gong has also hypothesised that "the introduction of any sacrificial bonds that yield and dissipate energy upon deformation will toughen the materials" [5] and that "the same DN gel concepts can, in principle, be applied to other self-healing types of materials, if the covalent bonds are replaced by reversible bonds" [3]. This hypothesis has been tested and found to be true by preparing gels with different types reversible sacrificial bonds including the hydrophobic interactions of molecules forming lamellar bilayers and ionic cross-links [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Strong tough gels for 3D tissue constructs

et al. 2014

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“…Hydrogel was produced as described by Chen et al (2013). Briefly, G. microphylla (100 mg) or guar gum (50 mg) was added to a small tube with 5 mL of H2O.…”

Section: Hydrogel Production and Mechanical Property Analysismentioning

confidence: 99%

“…Nevertheless, some materials lack adequate mechanical properties, tunable structure, and degradability, which can lead to potential immunogenic responses that compromise their utilization as biomaterials (Zhu 2010). Therefore, for these two types of gum, the facile one-pot method described by Chen et al (2013) was adopted to enhance the mechanical properties of the hydrogels for their applications in load-bearing artificial soft tissues.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characteristics of Gradual Fractionation Ingredients of Industrial Galactomannan Gums from Gleditsia microphylla and Cyamopsis tetragonoloba

Liu¹,

Xing²,

Liu³

et al. 2016

BioResources

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Galactomannan in industrial Gleditsia microphylla and guar gum was successfully fractionated by gradual precipitation in an aqueous solution with increasing ethanol concentrations. The molecular properties of each fraction were characterized, and the galactomannans were added to photopolymerized hydrogels to test their effects on mechanical properties and swelling capacity. In the series fractions of guar gum, the sample precipitated from 20% EtOH solution had the highest yield, mannose to galactose ratio, and viscosity, and it had a slightly lower molecular weight than that precipitated by 30% EtOH. Correspondingly, the best tensile property of its photopolymerized hydrogel was finally detected. In terms of G. microphylla gum, the precipitation in 30% EtOH solution achieved the highest yield, M/G ratio, and molecular weight value, and it exhibited the best rheological property of all the samples. The hydrogel with the addition of this sample also had the best mechanical properties despite its lower hydroscopicity than the blank hydrogel. The unique properties of each fraction could probably lead to their use as biodegradable alternatives in different applications.

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A Robust, One‐Pot Synthesis of Highly Mechanical and Recoverable Double Network Hydrogels Using Thermoreversible Sol‐Gel Polysaccharide

Cited by 624 publications

References 31 publications

Robust biopolymer based ionic–covalent entanglement hydrogels with reversible mechanical behaviour

Robust biopolymer based ionic–covalent entanglement hydrogels with reversible mechanical behaviour

Strong tough gels for 3D tissue constructs

Physicochemical Characteristics of Gradual Fractionation Ingredients of Industrial Galactomannan Gums from Gleditsia microphylla and Cyamopsis tetragonoloba

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