A robust mussel-inspired zwitterionic coating on biodegradable poly(L-lactide) stent with enhanced anticoagulant, anti-inflammatory, and anti-hyperplasia properties

Yang, Li; Wu, Haoshuang; Liu, Yuqi; Xia, Qiongfen; Yang, Yuan; Chen, Nuoya; Yang, Ming; Luo, Rifang; Liu, Gongyan; Wang, Yunbing

doi:10.1016/j.cej.2021.130910

Cited by 46 publications

(25 citation statements)

References 47 publications

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“…Alternatively, zwitterionic polymer coatings with anti-inflammatory properties have been extensively studied. Yang et al [ 77 ] synthesized zwitterionic poly (carboxybetaine acrylate–co–dopamine methacrylate) copolymer (PCBDA) that was inspired by mussel. Then, a zwitterionic polymer coating was formed on the surface of PLA stents by the co-deposition of poly (dopamine) (PDA) and polyethyleneimine (PEI).…”

Section: Functionalization Of Biodegradable Polymeric Stentsmentioning

confidence: 99%

Development of Biodegradable Polymeric Stents for the Treatment of Cardiovascular Diseases

Shen

Cui

et al. 2022

Biomolecules

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Cardiovascular disease has become the leading cause of death. A vascular stent is an effective means for the treatment of cardiovascular diseases. In recent years, biodegradable polymeric vascular stents have been widely investigated by researchers because of its degradability and clinical application potential for cardiovascular disease treatment. Compared to non-biodegradable stents, these stents are designed to degrade after vascular healing, leaving regenerated healthy arteries. This article reviews and summarizes the recent advanced methods for fabricating biodegradable polymeric stents, including injection molding, weaving, 3D printing, and laser cutting. Besides, the functional modification of biodegradable polymeric stents is also introduced, including visualization, anti-thrombus, endothelialization, and anti-inflammation. In the end, the challenges and future perspectives of biodegradable polymeric stents were discussed.

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Section: Functionalization Of Biodegradable Polymeric Stentsmentioning

confidence: 99%

Development of Biodegradable Polymeric Stents for the Treatment of Cardiovascular Diseases

Shen

Cui

et al. 2022

Biomolecules

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“…These biomimetic surfaces exhibit efficient anticoagulation and fibrinolytic activity. [21][22][23][24] Recently, heparin, hirudin, triflusal, resveratrol, dipyridamole, cilostazol, atorvastatin and ACH11 peptide have been demonstrated to significantly improve the hemocompatibility of biomaterial surfaces owing to their anticoagulant properties and because they can maintain their normal conformation and high bioactivity in coatings. [25][26][27] The co-immobilization of ACH11 peptide and PEG can reduce nonspecific protein adsorption and platelet aggregation, and importantly can inhibit Factor Xa formation.…”

Section: Bioactive Molecules and Drugsmentioning

confidence: 99%

Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia

et al. 2022

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“…PCBDA was cross-linked with polydopamine (PDA) and polyethyleneimine (PEI), which were co-deposited on the stent surface before adding the polyzwitterion. In vivo tests showed significant anticoagulating, anti-inflammatory and anti-proliferation capabilities [136]. In addition, poly [2-(methacryloyloxyethyl) phosphoryl choline] was used to treat Titanium (Ti) surfaces against protein adsorption, which can trigger various coagulation pathways.…”

Section: Implant Coatingsmentioning

confidence: 99%

Polybetaines in Biomedical Applications

Racoviţă¹,

Trofin²,

Loghin³

et al. 2021

IJMS

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Polybetaines, that have moieties bearing both cationic (quaternary ammonium group) and anionic groups (carboxylate, sulfonate, phosphate/phosphinate/phosphonate groups) situated in the same structural unit represent an important class of smart polymers with unique and specific properties, belonging to the family of zwitterionic materials. According to the anionic groups, polybetaines can be divided into three major classes: poly(carboxybetaines), poly(sulfobetaines) and poly(phosphobetaines). The structural diversity of polybetaines and their special properties such as, antifouling, antimicrobial, strong hydration properties and good biocompatibility lead to their use in nanotechnology, biological and medical fields, water remediation, hydrometallurgy and the oil industry. In this review we aimed to highlight the recent developments achieved in the field of biomedical applications of polybetaines such as: antifouling, antimicrobial and implant coatings, wound healing and drug delivery systems.

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A robust mussel-inspired zwitterionic coating on biodegradable poly(L-lactide) stent with enhanced anticoagulant, anti-inflammatory, and anti-hyperplasia properties

Cited by 46 publications

References 47 publications

Development of Biodegradable Polymeric Stents for the Treatment of Cardiovascular Diseases

Development of Biodegradable Polymeric Stents for the Treatment of Cardiovascular Diseases

Recent strategies for improving hemocompatibility and endothelialization of cardiovascular devices and inhibition of intimal hyperplasia

Polybetaines in Biomedical Applications

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