A robust hybrid nanozyme@hydrogel platform as a biomimetic cascade bioreactor for combination antitumor therapy

Hao, Yijun; Liu, Yandi; Tao, Na; Lou, Dongyang; Li, Juan; Sun, Xiaoyi; Liu, You‐Nian

doi:10.1039/c9bm01837a

Cited by 38 publications

(33 citation statements)

References 68 publications

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“…Then the catalytic performance of GOD was evaluated in normoxia condition via 3,5‐dinitrosalicylic acid (DNS) assay (Figure 1H). [ 18 ] After incubation with IONP, the concentration of glucose remained unchanged. In sharp contrast, the concentration of glucose in GOD and IONP‐GOD groups reduced 95.4% and 67.7%, respectively, exhibiting obvious glucose consumption.…”

Section: Resultsmentioning

confidence: 99%

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Shao

Wang

Hao

et al. 2021

Adv Healthcare Materials

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The unique tumor microenvironment (TME) characteristics such as immunosuppression impeded traditional cancer treatments. In contrast, developing cascade catalytic nanoplatforms by fully making use of substances in TME for cancer therapy may deserve full credit. Herein, a cascade catalytic nanoplatform based on glucose oxidase (GOD) modified mesoporous iron oxide nanoparticles (IONP) loaded with Artemisinin (ART) is developed, which is designed as IONP-GOD@ART. GOD can catalyze the oxidization of glucose into gluconic acid and H 2 O 2 , which not only realizes tumor starvation therapy, but also provides H 2 O 2 for IONP mediated Fenton reaction. Simultaneously, mesoporous IONP releases Fe 2+ and Fe 3+ ions in acidic TME. On the one hand, iron ions undergo Fenton reaction to generate hydroxyl radicals for chemodynamic therapy. On the other hand, the endoperoxide bridge in ART is broken in presence of Fe 2+ and further generates reactive oxygen species (ROS) to achieve therapeutic purpose. In this sense, IONP-GOD@ART manipulates TME characteristics and leads to "butterfly effect", which brings out a large amount of ROS for eliciting immunogenic cell death, inducing M1-TAMs polarization, and further reprogramming immunosuppressive TME for enhanced immunotherapy. By this delicate design, the cascade catalytic nanoplatform of IONP-GOD@ART realizes potent cancer immunotherapy for tumor regression and metastasis prevention.

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Section: Resultsmentioning

confidence: 99%

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Shao

Wang

Hao

et al. 2021

Adv Healthcare Materials

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“…Therefore, it is of great significance to search for valuable PTCAs for photothermal therapy. To date, mainstream PTCAs have mainly been divided into inorganic nanomaterials (such as carbon nanotubes, [ 29 ] Prussian blue (PB), [ 34,82 ] CuMoS 4 , [ 10a ] Cu 2‐ x Se, [ 71 ] Bi 2 Se 3 , [ 12a ] and liquid metal [ 33 ] ) and organic nanoparticles (including PDA [ 13c,46d,49 ] and Ppy [ 46a ] ). Because the enzyme activity of GOx is affected by temperature, PTT that is within a certain temperature range can change the enzyme activity of GOx and thus enhance starvation therapy.…”

Section: Gox‐instructed Cancer Therapiesmentioning

confidence: 99%

“…For example, a hybrid nanozyme@hydrogel (hPB@gellan) is doped with PB nanoparticles via the in situ nanoprecipitation method in the polysaccharide gellan matrix, in which PB nanoparticles are a photothermal agent, with a photothermal conversion efficiency of 59.6%, as well as a CAT‐like nanozyme that catalyzes H 2 O 2 into O 2 . [ 34 ] The cascade bioreactor formed by incorporating GOx into the hybrid hydrogel shows prolonged retention time and induces enhanced starvation and photothermal therapy. This strategy was also confirmed by another study in which a tumor‐targeted redox‐responsive composite biocatalyst (PHPBNs‐S‐S‐HA‐PEG@GOx) was fabricated by loading porous hollow PB nanoparticles (PHPBNs) with GOx and then carpeting them with HA via a redox‐cleavable linkage to protect GOx from degradation ( Figure ).…”

Section: Gox‐instructed Cancer Therapiesmentioning

confidence: 99%

Glucose Oxidase‐Related Cancer Therapies

Wang

Yang

Dong

et al. 2020

Advanced Therapeutics

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Glucose oxidase (GOx), which catalyzes the conversion of glucose into gluconic acid and hydrogen peroxide (H 2 O 2) in the presence of oxygen (O 2), has aroused growing interest for cancer therapy. GOx can starve tumor cells to death by depleting glucose, which is very important for their energy supply, and the generated H 2 O 2 is can be used for oxidation therapy. In addition, GOx-catalyzed glucose oxidation exerts a variety of effects on the tumor environment, such as enhancing hypoxia and increasing acidity. The full use of these characteristics can effectively reduce side effects and enhance the therapeutic efficiency of GOx-related cancer therapies. As is generally acknowledged, it is difficult to completely eliminate tumors with a single treatment, whereas combining two or more therapies may yield super-additive results because when properly designed, different treatments can compensate for the shortcomings of the other treatments and bring out the best in each other. In view of these facts, enhanced therapies and combination therapies related to glucose oxidation have been widely studied, and this review provides a systematic overview of recent research on GOx-related cancer therapies (especially starvation therapy) from the perspective of glucose oxidation (including the reaction itself, oxygen, enzymes, gluconic acid, and H 2 O 2) and other combination therapies.

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“…[ 4,9,10 ] A large number of nanosystems, constructed from metal, [ 11–15 ] inorganics, [ 16–18 ] or organic molecules, [ 19,20 ] have been reported to show catalytic abilities similar to those of natural enzymes. These biocatalytic nanomaterials have also been defined as enzyme‐mimics (Enz‐Ms), or nanozymes in some cases, [ 21–24 ] which have presented promising applications in tumor therapies, [ 25 ] biosensing, [ 26 ] antipathogen, [ 27 ] and wound healing. [ 28 ] Especially with the fast evolution of synthetic and fabrication methods, the morphology, composition, and proportion of nanoparticles in Enz‐Ms are regulated reasonably and efficiently in recent years.…”

Section: Introductionmentioning

confidence: 99%

Engineering Biofunctional Enzyme‐Mimics for Catalytic Therapeutics and Diagnostics

Tang

Cao

et al. 2020

Adv Funct Materials

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The applications of nanomaterial‐based enzyme‐mimics (Enz‐Ms) in biocatalytically therapeutic and diagnostic fields have attracted extensive attention. The regulation of the biocatalytic performances and biofunctionalities of Enz‐Ms are essential research objectives, including the rational design and synthesis of Enz‐Ms with desired biofunctional molecules and nanostructures, especially at the level of molecules and even single atoms. Here, this timely progress report provides pivotal advances and comments on recent researches on engineering biofunctional Enz‐Ms (BF/Enz‐Ms), particularly chemical synthesis, functionalization strategies, and integration of diverse enzyme‐mimetic catalytic activities of BF/Enz‐Ms. First, the definitions and catalogs of BF/Enz‐Ms are briefly introduced. Then, detailed comments and discussions are provided on the fabrication protocols, biocatalytic properties, and therapeutic/diagnostic applications of engineered BF/Enz‐Ms via hydrogels, nanogels, metal–organic frameworks, metal–polyphenol networks, covalent–organic frameworks, functional cell membranes, bioactive molecules and polymers, and composites. Finally, the future perspectives and challenges on BF/Enz‐Ms are outlined and thoroughly discussed. It is believed that this progress report will give a chemical and material overview on the state‐of‐the‐art designing principles of BF/Enz‐Ms, thus further promoting their future developments and prosperities for a wide range of applications.

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A robust hybrid nanozyme@hydrogel platform as a biomimetic cascade bioreactor for combination antitumor therapy

Abstract: The development of highly effective and minimally invasive approaches for cancer treatment is the ultimate goal.

Cited by 38 publications

References 68 publications

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Cascade Catalytic Nanoplatform Based on “Butterfly Effect” for Enhanced Immunotherapy

Glucose Oxidase‐Related Cancer Therapies

Engineering Biofunctional Enzyme‐Mimics for Catalytic Therapeutics and Diagnostics

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