A robust diving response in the laboratory mouse

Hult, Elissa M; Bingaman, Mark J.; Swoap, Steven J.

doi:10.1007/s00360-019-01237-5

Cited by 7 publications

(9 citation statements)

References 42 publications

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“…Rats can be trained easily to dive underwater (McCulloch, 2012;; Supplementary Video S1), and the DR can be documented (Figure 1) with implanted telemetric transmitters (McCulloch et al, 2010;Panneton et al, 2010aPanneton et al, ,b, 2012a. The DR has also been documented recently in mice (Hult et al, 2019); the authors also provide a simple training protocol for these irascible creatures. These studies have shown that responses in diving rodents mimic those of marine mammals; the use of laboratory rodents for studying the DR has been reviewed recently (McCulloch, 2012).…”

Section: Introductionmentioning

confidence: 75%

“…Discussions of techniques employed will not be emphasized in this review. However, interested readers are referred to manuscripts with numerous references detailing the location of the anterior ethmoidal nerve (AEN; Panneton, 1991a) and its recording/stimulation (McCulloch et al, 1999a) stimulating the nasal mucosa with vapors (Panneton, 1991b;Panneton and Yavari, 1995;Yavari et al, 1996;Panneton et al, 2010b), for transganglionic transport techniques from primary afferent fibers (Panneton, 1991a;Panneton et al, 2006;, for pharmacological blockade of central pathways (Panneton and Yavari, 1995;McCulloch et al, 1999b), for neuroanatomical tract-tracing of central pathways (Panneton et al, 2000(Panneton et al, , 2006, for the use of cFos as a neuroanatomical marker of function (Panneton et al, 2010a(Panneton et al, , 2012a, for the training of rats and mice to dive (McCulloch, 2014;Hult et al, 2019), and for deployment of telemetric transmitters to measure cardiovascular changes in both trained rats (Panneton et al, 2010a(Panneton et al, ,b, 2012a) and mice (Hult et al, 2019). The limitations of these techniques are discussed in these manuscripts.…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, genetic studies are now underway illustrating how diving mammals, including humans, have adapted to their anoxic underwater environments (Fabrizius et al, 2016;Baranova et al, 2017;Hoff et al, 2017;Ilardo et al, 2018;Zhou et al, 2018;Xu et al, 2019). Introduction of the DR in the mouse (Hult et al, 2019) provides opportunity for an entirely novel set of techniques for genetic manipulation of neurons. Utilization of these data on the DR in rodents thus provides practical animal models for study of the mechanisms driving the response, data from which could be applied to humans.…”

Section: The Diving Response In the Humanmentioning

confidence: 99%

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The Mammalian Diving Response: Inroads to Its Neural Control

Panneton

Gan

2020

Front. Neurosci.

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The mammalian diving response (DR) is a remarkable behavior that was first formally studied by Laurence Irving and Per Scholander in the late 1930s. The DR is called such because it is most prominent in marine mammals such as seals, whales, and dolphins, but nevertheless is found in all mammals studied. It consists generally of breathing cessation (apnea), a dramatic slowing of heart rate (bradycardia), and an increase in peripheral vasoconstriction. The DR is thought to conserve vital oxygen stores and thus maintain life by directing perfusion to the two organs most essential for life-the heart and the brain. The DR is important, not only for its dramatic power over autonomic function, but also because it alters normal homeostatic reflexes such as the baroreceptor reflex and respiratory chemoreceptor reflex. The neurons driving the reflex circuits for the DR are contained within the medulla and spinal cord since the response remains after the brainstem transection at the pontomedullary junction. Neuroanatomical and physiological data suggesting brainstem areas important for the apnea, bradycardia, and peripheral vasoconstriction induced by underwater submersion are reviewed. Defining the brainstem circuit for the DR may open broad avenues for understanding the mechanisms of suprabulbar control of autonomic function in general, as well as implicate its role in some clinical states. Knowledge of the proposed diving circuit should facilitate studies on elite human divers performing breath-holding dives as well as investigations on sudden infant death syndrome (SIDS), stroke, migraine headache, and arrhythmias. We have speculated that the DR is the most powerful autonomic reflex known.

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Section: Introductionmentioning

confidence: 75%

Section: Methodsmentioning

confidence: 99%

Section: The Diving Response In the Humanmentioning

confidence: 99%

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The Mammalian Diving Response: Inroads to Its Neural Control

Panneton

Gan

2020

Front. Neurosci.

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“…Rat physiological responses to diving are different than those in swimming. In the diving state, they exhibit a decrease in arterial pressure and heart rate (Hult et al, 2019). Therefore, a diving rat is susceptible to hypoxemia condition i.e.…”

Section: Resultsmentioning

confidence: 99%

Voluntary Diving Exercise Improves Hippocampus-dependent Learning in Rats

Hartantyo

Putro

Torop

et al. 2020

bio

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Several physiological alterations that arise in response to hypoxemia conditions when diving are intended to protect oxygen-sensitive organs from the hypoxic condition. Hippocampus, known for its central function in memory formation, is sensitive to hypoxic conditions. This research aimed to study the effect of voluntary diving exercise (VDE) on the hippocampus-dependent learning performance of rats. Rats were divided into control and diving groups, with swim and voluntary diving exercises every day for 60 days, respectively. Observation of memory consolidation was carried out using Morris Water Maze (MWM) and Novel Object Recognition (NOR) tests. In the MWM test, the escape latencies in the diving group were shorter than those in the control group. Consistent results were obtained in the MWM probe trial which the time spent in the target quadrant was significantly longer in the diving group. Moreover, the diving group spent more time exploring the novel object in the NOR test. Based on the results, we can conclude that 60 days VDE significantly improves hippocampus-dependent learning capacity in trained rats.

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“…Forced swimming test [ 68 , 69 , 70 , 71 , 72 , 73 ] recording the animal's maximum swimming time represent physical performance capability. A mouse with 13% of body weight load fixed on the middle part of the tail was placed in water.…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice

Averina

Laptev

Emelianova

et al. 2022

IJMS

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Mitochondrial translation is a unique relic of the symbiotic origin of the organelle. Alterations of its components cause a number of severe human diseases. Hereby we report a study of mice devoid of Mettl15 mitochondrial 12S rRNA methyltransferase, responsible for the formation of m4C839 residue (human numbering). Homozygous Mettl15−/− mice appeared to be viable in contrast to other mitochondrial rRNA methyltransferase knockouts reported earlier. The phenotype of Mettl15−/− mice is much milder than that of other mutants of mitochondrial translation apparatus. In agreement with the results obtained earlier for cell cultures with an inactivated Mettl15 gene, we observed accumulation of the RbfA factor, normally associated with the precursor of the 28S subunit, in the 55S mitochondrial ribosome fraction of knockout mice. A lack of Mettl15 leads to a lower blood glucose level after physical exercise relative to that of the wild-type mice. Mettl15−/− mice demonstrated suboptimal muscle performance and lower levels of Cox3 protein synthesized by mitoribosomes in the oxidative soleus muscles. Additionally, we detected decreased learning capabilities in the Mettl15−/− knockout mice in the tests with both positive and negative reinforcement. Such properties make Mettl15−/− knockout mice a suitable model for mild mitochondriopathies.

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A robust diving response in the laboratory mouse

Cited by 7 publications

References 42 publications

The Mammalian Diving Response: Inroads to Its Neural Control

The Mammalian Diving Response: Inroads to Its Neural Control

Voluntary Diving Exercise Improves Hippocampus-dependent Learning in Rats

Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice

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