A Roadmap Followed: The Path Towards the Elimination of Onchocerciasis in Latin America

Rodríguez‐Pérez, Mario A.; Lara-Ramírez, Edgar E.; Real-Najarro, Olga; Unnasch, Thomas R.

doi:10.1007/978-3-7091-1422-3_8

Cited by 2 publications

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“…China and Puerto Rico relied in an important way on snail control supported by WASH and health education [ 29 , 37 – 42 ]. Similarly, vector control has been instrumental for the control and elimination of other parasitic and vector-borne diseases such as malaria, dengue, onchocerciasis and Guinea worm [ 43 – 57 ].…”

Section: Resultsmentioning

confidence: 99%

“…The need for multipronged elimination strategies has also been highlighted for other parasitic and vector-borne diseases including malaria [ 32 , 44 , 49 , 98 – 100 ], dengue [ 43 , 46 , 56 , 60 ], onchocerciasis [ 57 ] and Guinea worm [ 45 , 52 , 54 ]. Examples of integrated, inter-programmatic and cross-sectoral initiatives have been outlined in detail for prevention, control and elimination of NTDs in the Americas [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

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Core components, concepts and strategies for parasitic and vector-borne disease elimination with a focus on schistosomiasis: A landscape analysis

et al. 2020

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Efforts to control and eliminate human schistosomiasis have accelerated over the past decade. In a number of endemic countries and settings, interruption of schistosome transmission has been achieved. In others, Schistosoma infections continue to challenge program managers at different levels, from the complexity of the transmission cycle, over limited treatment options and lack of field-friendly accurate diagnostics, to controversy around adequate intervention strategies. We conducted a landscape analysis on parasitic and vector-borne disease elimination approaches with the aim to identify evidence-based strategies, core components and key concepts for achieving and sustaining schistosomiasis control and for progressing elimination efforts towards interruption of transmission in sub-Saharan Africa. A total of 118 relevant publications were identified from Web of Science, Pubmed and the grey literature and reviewed for their content. In addition, we conducted in-depth interviews with 23 epidemiologists, program managers, policymakers, donors and field researchers. Available evidence emphasizes the need for comprehensive, multipronged and long-term strategies consisting of multiple complementary interventions that must be sustained over time by political commitment and adequate funding in order to reach interruption of transmission. Based on the findings of this landscape analysis, we propose a comprehensive set of intervention strategies for schistosomiasis control and elimination. Before deployment, the proposed interventions will require review, evaluation and validation in the frame of an expert consultation as a step towards adaptation to specific contexts, conditions and settings. Field testing to ensure local relevance and effectiveness is paramount given the diversity of socio-ecological and epidemiological contexts.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Core components, concepts and strategies for parasitic and vector-borne disease elimination with a focus on schistosomiasis: A landscape analysis

et al. 2020

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Factors affecting onchocerciasis transmission: lessons for infection control

Cheke

2017

Expert Review of Anti-infective Therapy

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Introduction: Onchocerca volvulus infects in excess of 15 million people. The vectors are Simulium blackflies, varieties of which differ in their ecologies, behaviour and vectorial abilities. Control of the vectors and mass administrations of ivermectin have succeeded in reducing prevalences with elimination achieved in some foci, particularly in Central and southern America. In Africa, progress towards elimination has been less successful.Areas covered: Even with community directed treatment with ivermectin (CDTI), control has been difficult in African areas with initial prevalences in excess of 55%, especially if only annual treatments are dispensed. This is partly attributable to insufficient coverage, but the appearance of incipiently resistant non-responding parasites and lack of attention to vector biology in modelling and planning outcomes of intervention programmes have also played their parts, with recrudescence now appearing in some treated areas. Expert commentary:The biology of onchocerciasis is complex involving different vectors with differing abilities to transmit parasites, diverse pathologies related to geographical and parasite variations and endosymbionts in both parasite and vector. Modelling to predict epidemiological and control outcomes is addressing this complexity but more attention needs to be given to the vectors' roles to further understanding of where and when control measures will succeed.

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A Roadmap Followed: The Path Towards the Elimination of Onchocerciasis in Latin America

Cited by 2 publications

References 61 publications

Core components, concepts and strategies for parasitic and vector-borne disease elimination with a focus on schistosomiasis: A landscape analysis

Core components, concepts and strategies for parasitic and vector-borne disease elimination with a focus on schistosomiasis: A landscape analysis

Factors affecting onchocerciasis transmission: lessons for infection control

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